2023
The rich non-coding RNA landscape of the Drosophila antenna
Talross G, Carlson J. The rich non-coding RNA landscape of the Drosophila antenna. Cell Reports 2023, 42: 112482. PMID: 37167060, PMCID: PMC10431215, DOI: 10.1016/j.celrep.2023.112482.Peer-Reviewed Original ResearchConceptsDrosophila antennaPheromone-sensing neuronsLong non-coding RNAsNon-coding RNAsDrosophila olfactory systemRole of lncRNAsMultiple complex behaviorsRNA landscapeOlfactory receptor neuronsNeuronal lncRNAsNeural developmentLncRNAsReceptor neuronsModel systemPheromonal responsesOlfactory systemCritical roleNeuron mapNervous systemRNACombination of lncRNAsSpeciationNeuronsRoleA volatile sex attractant of tsetse flies
Ebrahim S, Dweck H, Weiss B, Carlson J. A volatile sex attractant of tsetse flies. Science 2023, 379: eade1877. PMID: 36795837, PMCID: PMC10204727, DOI: 10.1126/science.ade1877.Peer-Reviewed Original Research
2019
The molecular and cellular basis of olfactory response to tsetse fly attractants
Chahda JS, Soni N, Sun JS, Ebrahim SAM, Weiss BL, Carlson JR. The molecular and cellular basis of olfactory response to tsetse fly attractants. PLOS Genetics 2019, 15: e1008005. PMID: 30875383, PMCID: PMC6420007, DOI: 10.1371/journal.pgen.1008005.Peer-Reviewed Original ResearchMeSH Keywords2-PropanolAnimalsDrosophila melanogasterHumansOilsOlfactory Receptor NeuronsReceptors, OdorantSex AttractantsSmellTrypanosomaTrypanosomiasis, AfricanTsetse FliesConceptsOlfactory receptor neuronsSensory pitsCellular basisHeterologous expression systemTsetse fly Glossina morsitansTerrestrial habitatsExpression systemGene expressionEmpty neuronAnimal matterOlfactory responsesSpecialized subtypesMajor vectorStrong attractantReceptor gene expressionG. fuscipesDrosophilaMalarial parasitesReceptor neuronsFliesAttractantsDevastating diseaseOlfactory systemBlood of humansGlossina morsitans
2012
Non-synaptic inhibition between grouped neurons in an olfactory circuit
Su CY, Menuz K, Reisert J, Carlson JR. Non-synaptic inhibition between grouped neurons in an olfactory circuit. Nature 2012, 492: 66-71. PMID: 23172146, PMCID: PMC3518700, DOI: 10.1038/nature11712.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsDrosophila olfactory receptor neuronsMalaria mosquito AnophelesMosquito AnophelesMammalian taste budsSustained responseInsect controlLateral inhibitionBroad occurrenceChemosensory sensillaOlfactory behaviorTransient activationSensory organsMarked compartmentalizationOlfactory circuitFunctional impactReceptor neuronsReceptor cellsOlfactory informationInhibitionInsectsTaste budsNeuronsCompartmentalizationBuds
2010
Odorant reception in the malaria mosquito Anopheles gambiae
Carey AF, Wang G, Su CY, Zwiebel LJ, Carlson JR. Odorant reception in the malaria mosquito Anopheles gambiae. Nature 2010, 464: 66-71. PMID: 20130575, PMCID: PMC2833235, DOI: 10.1038/nature08834.Peer-Reviewed Original ResearchConceptsMosquito Anopheles gambiaeOdorant receptor repertoireAnopheles gambiaeMalaria mosquito Anopheles gambiaeOdorant receptionReceptor repertoireMolecular basisHost-seeking behaviorEcological needsMajor vectorHuman hostTransmission of malariaGambiaeUseful targetCentral roleReceptorsStrong responseRepertoireMalariaSaharan AfricaSpeciesOdorants
2009
Olfactory Perception: Receptors, Cells, and Circuits
Su CY, Menuz K, Carlson JR. Olfactory Perception: Receptors, Cells, and Circuits. Cell 2009, 139: 45-59. PMID: 19804753, PMCID: PMC2765334, DOI: 10.1016/j.cell.2009.09.015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansOlfactory PathwaysOlfactory PerceptionOlfactory Receptor NeuronsReceptors, Odorant
2008
A New Drosophila POU Gene, pdm3, Acts in Odor Receptor Expression and Axon Targeting of Olfactory Neurons
Tichy AL, Ray A, Carlson JR. A New Drosophila POU Gene, pdm3, Acts in Odor Receptor Expression and Axon Targeting of Olfactory Neurons. Journal Of Neuroscience 2008, 28: 7121-7129. PMID: 18614681, PMCID: PMC2572001, DOI: 10.1523/jneurosci.2063-08.2008.Peer-Reviewed Original ResearchConceptsPOU genesOlfactory receptor neuronsAxon targetingReceptor gene choiceClasses of ORNsReceptor expressionGenetic interactionsGene choiceGene codesORN classesPdm3Genetic analysisMutational analysisOdor responsesMolecular mechanismsGenesOlfactory neuronsReceptor neuronsIndividual receptorsDifferential activationOlfactory systemProper transmissionExpressionFunctional organizationTargetingA Regulatory Code for Neuron-Specific Odor Receptor Expression
Ray A, van Naters W, Carlson JR. A Regulatory Code for Neuron-Specific Odor Receptor Expression. PLOS Biology 2008, 6: e125. PMID: 18846726, PMCID: PMC2430909, DOI: 10.1371/journal.pbio.0060125.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsORN classesAxon guidance genesOdor receptorsAmino acid sequenceMost olfactory receptor neuronsReceptor gene regulationDrosophila speciesPhylogenetic approachGene regulationGenome sequenceTranscription factorsIndividual olfactory receptor neuronsRegulatory elementsAcid sequenceChemosensory organsRegulatory codeGenetic analysisMaxillary palpsGenesLarge repertoireReceptor neuronsReceptor geneExpressionNeuron map
2007
Receptors and Neurons for Fly Odors in Drosophila
van Naters W, Carlson JR. Receptors and Neurons for Fly Odors in Drosophila. Current Biology 2007, 17: 606-612. PMID: 17363256, PMCID: PMC1876700, DOI: 10.1016/j.cub.2007.02.043.Peer-Reviewed Original ResearchConceptsCis-vaccenyl acetateOlfactory receptor neuronsTrichoid sensillaAnti-aphrodisiac pheromoneReceptor gene familyVirgin femalesVivo expression systemGene familyMate recognitionMating partnersDrosophila antennaExpression systemORN populationCellular basisReceptor neuronsYield responseSensillaMale extractsElectrophysiological analysisFood odorsReceptorsDrosophilaMajor typesPheromoneFemalesMechanisms of Odor Receptor Gene Choice in Drosophila
Ray A, van Naters Wv, Shiraiwa T, Carlson JR. Mechanisms of Odor Receptor Gene Choice in Drosophila. Neuron 2007, 53: 353-369. PMID: 17270733, PMCID: PMC1986798, DOI: 10.1016/j.neuron.2006.12.010.Peer-Reviewed Original ResearchConceptsReceptor gene choiceOlfactory receptor neuronsGene choiceNegative regulatory elementAsymmetric segregationAlternative splicingNegative feedback regulationSingle geneTranscription factorsORN classesRegulatory elementsCombinatorial codeDicistronic mRNACommon progenitorMutational analysisDrosophilaRegulatory factorsOlfactory organFeedback regulationOdor receptorsReceptor neuronsReceptor geneGenesNeuron mapReceptor repertoire
2005
The Molecular Basis of Odor Coding in the Drosophila Larva
Kreher SA, Kwon JY, Carlson JR. The Molecular Basis of Odor Coding in the Drosophila Larva. Neuron 2005, 46: 445-456. PMID: 15882644, DOI: 10.1016/j.neuron.2005.04.007.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsDrosophila larvaeMolecular basisVivo expression systemDifferent olfactory systemsFamily of receptorsSingle olfactory receptor neuronsLarval brainSpecificity mapsLarval antennal lobeExpression systemMolecular mechanismsOdor codingOdor receptorsReceptor neuronsIndividual receptorsAntennal lobeLongstanding observationGenesOlfactory systemLarvaeBreadth of tuningSingle glomerulusReceptorsOdor informationCoexpression of Two Functional Odor Receptors in One Neuron
Goldman AL, van Naters W, Lessing D, Warr CG, Carlson JR. Coexpression of Two Functional Odor Receptors in One Neuron. Neuron 2005, 45: 661-666. PMID: 15748842, DOI: 10.1016/j.neuron.2005.01.025.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedDrosophila melanogasterGene Expression RegulationNeuronsOlfactory Receptor NeuronsReceptors, Odorant
2004
The Molecular Basis of Odor Coding in the Drosophila Antenna
Hallem EA, Ho MG, Carlson JR. The Molecular Basis of Odor Coding in the Drosophila Antenna. Cell 2004, 117: 965-979. PMID: 15210116, DOI: 10.1016/j.cell.2004.05.012.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsDrosophila antennaMolecular basisOdorant receptor repertoireFunctional analysisReceptor repertoireOlfactory organOdor codingReceptor neuronsIndividual receptorsSame cellsReceptor transductionNumber of receptorsNeuron mapReceptorsRepertoireBreadth of tuningTransductionDifferent odorantsInhibitory responsesOdorantsElectrophysiological recordingsNeuronsCellsVivo
1999
Olfactory Adaptation Depends on the Trp Ca2+Channel in Drosophila
Störtkuhl K, Hovemann B, Carlson J. Olfactory Adaptation Depends on the Trp Ca2+Channel in Drosophila. Journal Of Neuroscience 1999, 19: 4839-4846. PMID: 10366618, PMCID: PMC6782652, DOI: 10.1523/jneurosci.19-12-04839.1999.Peer-Reviewed Original ResearchOdor Coding in a Model Olfactory Organ: TheDrosophila Maxillary Palp
de Bruyne M, Clyne P, Carlson J. Odor Coding in a Model Olfactory Organ: TheDrosophila Maxillary Palp. Journal Of Neuroscience 1999, 19: 4520-4532. PMID: 10341252, PMCID: PMC6782632, DOI: 10.1523/jneurosci.19-11-04520.1999.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsDrosophila melanogasterMaleModels, AnatomicOdorantsOlfactory PathwaysOlfactory Receptor NeuronsSense OrgansConceptsReceptor neuronsOlfactory organOlfactory receptor neuronsCross-adaptation experimentsExcitatory responsesNeuronal typesExtracellular recordingsParticular neuronsNeuronsFunctional classSensilla typesOdor responsesOdor codingOlfactory informationOdor deliveryOrgansMaxillary palpsSensory hairsFunctional organizationSingle sensillaResponseDeliveryOlfactory codeParticular odorTwo-neuron