2003
Drosophila Gr5a encodes a taste receptor tuned to trehalose
Chyb S, Dahanukar A, Wickens A, Carlson JR. Drosophila Gr5a encodes a taste receptor tuned to trehalose. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14526-14530. PMID: 14523229, PMCID: PMC304113, DOI: 10.1073/pnas.2135339100.Peer-Reviewed Original ResearchConceptsG protein-coupled receptor genesDrosophila S2 cell lineS2 cell lineFirst functional expressionTaste receptorsHeterologous expressionGenetic analysisFunctional expressionGr5aTaste sensillaReceptor geneCell linesGenesLabellar sensillaExpressionSensillaTaste neuronsReceptorsRecent studiesLabellumSensory responsesFliesNeuronsTrehaloseFamily
2001
A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila
Dahanukar A, Foster K, van der Goes van Naters W, Carlson J. A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila. Nature Neuroscience 2001, 4: 1182-1186. PMID: 11704765, DOI: 10.1038/nn765.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, Genetically ModifiedBase SequenceBehavior, AnimalCodonDose-Response Relationship, DrugDrosophilaFood, FormulatedGene DeletionGene Expression RegulationGenetic LinkageGTP-Binding ProteinsMaleMutationNeurons, AfferentPhenotypeProtein BiosynthesisReceptors, Cell SurfaceSucroseTasteTrehaloseX ChromosomeConceptsGR geneG protein-coupled receptor genesSugar trehaloseG protein-mediated signalingDrosophila genome databaseTransgenic rescue experimentsProtein-mediated signalingSpecificity of expressionGenome databaseTaste receptorsDifferent mutantsRescue experimentsGenesLarge familyGr5aDrosophilaFunctional evidenceReceptor geneGR receptorsTaste ligandsGustatory neuronsTaste neuronsTrehaloseReceptorsFamily members