2010
Confirmation and Generalization of an Alcohol-Dependence Locus on Chromosome 10q
Panhuysen CI, Kranzler HR, Yu Y, Weiss RD, Brady K, Poling J, Farrer LA, Gelernter J. Confirmation and Generalization of an Alcohol-Dependence Locus on Chromosome 10q. Neuropsychopharmacology 2010, 35: 1325-1332. PMID: 20147890, PMCID: PMC2855759, DOI: 10.1038/npp.2010.1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlcohol-Induced Disorders, Nervous SystemAlcoholismBlack or African AmericanChromosome MappingChromosomes, Human, Pair 10FemaleGene FrequencyGenetic LinkageGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedPenetranceWhite PeopleYoung AdultConceptsLinkage peakLOD scoreGenome-wide linkage scanLinkage analysisSignificant linkage peakNon-parametric linkage analysisParametric linkage analysisChromosome 10 markersSignificant LOD scorePeak lod scoreGenome scanLinkage scanRisk lociChromosome 10Chromosome 7Suggestive linkageAA sampleAD-related traitsLociChromosome 10qDistinct populationsTraitsEA samplesFamilyAD phenotype
2006
Genomewide Linkage Scan for Nicotine Dependence: Identification of a Chromosome 5 Risk Locus
Gelernter J, Panhuysen C, Weiss R, Brady K, Poling J, Krauthammer M, Farrer L, Kranzler HR. Genomewide Linkage Scan for Nicotine Dependence: Identification of a Chromosome 5 Risk Locus. Biological Psychiatry 2006, 61: 119-126. PMID: 17081504, DOI: 10.1016/j.biopsych.2006.08.023.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingChromosomes, Human, Pair 5FemaleGene FrequencyGenetic LinkageGenetic Predisposition to DiseaseHumansLod ScoreMaleMixed Function OxygenasesMultienzyme ComplexesNuclear FamilyPedigreePhenotypePolymorphism, Single NucleotideReproducibility of ResultsRetrospective StudiesTobacco Use DisorderConceptsRisk lociLinkage scanGenomewide linkage scanSignificant single-nucleotide polymorphism associationsGenetic linkage analysisSingle nucleotide polymorphism associationsHighest LOD scoreLinkage peakChromosome 5Linkage signalChromosome 7Small nuclear familiesLinkage analysisPeptidylglycine alphaLociLOD scoreDistinct populationsMultiple individualsGenesEA subjectsPhysiological hypothesisPolymorphism associationAA partEuropean Americans
2003
The Structure of Linkage Disequilibrium at the DBH Locus Strongly Influences the Magnitude of Association between Diallelic Markers and Plasma Dopamine β-Hydroxylase Activity
Zabetian CP, Buxbaum SG, Elston RC, Köhnke MD, Anderson GM, Gelernter J, Cubells JF. The Structure of Linkage Disequilibrium at the DBH Locus Strongly Influences the Magnitude of Association between Diallelic Markers and Plasma Dopamine β-Hydroxylase Activity. American Journal Of Human Genetics 2003, 72: 1389-1400. PMID: 12730829, PMCID: PMC1180300, DOI: 10.1086/375499.Peer-Reviewed Original ResearchConceptsQuantitative trait lociHuman genomeDBH locusLow haplotype diversityTotal phenotypic varianceLarge-scale association studiesLinkage disequilibrium mappingDiallelic markersPutative functional polymorphismsComplex traitsHaplotype diversityGenomewide scaleObserved chromosomesHaplotype mapPhenotypic varianceGenomewide basisDegree of LDAssociation studiesDisequilibrium mappingUpstream regionHaplotype blocksLinkage disequilibriumLociDistinct populationsGenome