2019
Clinical Insignficance of Monoclonal T-Cell Populations and Duodenal Intraepithelial T-Cell Phenotypes in Celiac and Nonceliac Patients
Celli R, Hui P, Triscott H, Bogardus S, Gibson J, Hwang M, Robert ME. Clinical Insignficance of Monoclonal T-Cell Populations and Duodenal Intraepithelial T-Cell Phenotypes in Celiac and Nonceliac Patients. The American Journal Of Surgical Pathology 2019, 43: 151-160. PMID: 30334829, DOI: 10.1097/pas.0000000000001172.Peer-Reviewed Original ResearchMeSH KeywordsCeliac DiseaseClone CellsDuodenumHumansIntraepithelial LymphocytesPhenotypeT-Lymphocyte SubsetsConceptsRefractory celiac diseaseT cell populationsMonoclonal T-cell populationRCD IRCD IICeliac diseasePersistent symptomsCD patientsIntraepithelial lymphocytesType II refractory celiac diseaseCD8-positive intraepithelial lymphocytesClonal T-cell populationsT-cell receptor gene rearrangementsAbnormal intraepithelial lymphocytesT-cell phenotypeReceptor gene rearrangementsParaffin-embedded biopsiesParaffin-embedded tissuesCD8 stainingLymphocyte phenotypingNonceliac patientsVillous bluntingDuodenal biopsiesRare conditionSpecialized centers
2014
A Humanized Mouse Model of Autoimmune Insulitis
Milam A, Maher SE, Gibson JA, Lebastchi J, Wen L, Ruddle NH, Herold KC, Bothwell AL. A Humanized Mouse Model of Autoimmune Insulitis. Diabetes 2014, 63: 1712-1724. PMID: 24478396, PMCID: PMC3994947, DOI: 10.2337/db13-1141.Peer-Reviewed Original ResearchConceptsT cellsDiabetic donorsInsulin stainingMouse modelAntigen-pulsed cellsAutoantigen-derived peptidesNOD mouse modelHumanized mouse modelType 1 diabetesPancreatic β-cellsT cell linesHuman T cellsIslet infiltrationAutoimmune diabetesNOD-SCIDAutoimmune insulitisHuman diabetesDestructive infiltrationMouse isletsMechanism of inductionΒ-cellsDiabetesDiabetes researchDisease modelsInsulitis