Featured Publications
Morphogenesis and cell ordering in confined bacterial biofilms
Zhang Q, Li J, Nijjer J, Lu H, Kothari M, Alert R, Cohen T, Yan J. Morphogenesis and cell ordering in confined bacterial biofilms. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2107107118. PMID: 34330824, PMCID: PMC8346881, DOI: 10.1073/pnas.2107107118.Peer-Reviewed Original ResearchConceptsInherent developmental programsBiofilm-dwelling cellsBiofilm-forming speciesSingle-cell imagingDevelopmental programSpecific matrix componentsCell orderingBiofilm developmentSpherical biofilmsBacterial cellsCell communityExtracellular matrixBiofilm morphologyBacterial biofilmsBiophysical mechanismsMatrix componentsHost tissuesBiofilmsBiofilm growthStiff gelsCellsMorphogenesisMutagenesisSpeciesVibrio
2020
Nonuniform growth and surface friction determine bacterial biofilm morphology on soft substrates
Fei C, Mao S, Yan J, Alert R, Stone H, Bassler B, Wingreen N, Košmrlj A. Nonuniform growth and surface friction determine bacterial biofilm morphology on soft substrates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 7622-7632. PMID: 32193350, PMCID: PMC7148565, DOI: 10.1073/pnas.1919607117.Peer-Reviewed Original ResearchConceptsBiofilm matrix productionBiofilm morphologyBacterial biofilmsAvailability of nutrientsDistinct spatiotemporal patternsImportant physiological consequencesAgar substrateMatrix productionMechanistic insightsPhysiological consequencesBiofilmsSoft substratesSimilar morphologyDiffusion of nutrientsPattern formation processNutrientsBasic mechanismsAgar concentrationEukaryotesMorphological patternsMorphogenesisFundamental determinantsOrganismsGrowthVibrio