2013
Lower Hospital Volume Is Associated With Higher In-Hospital Mortality in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction
Kontos MC, Wang Y, Chaudhry SI, Vetrovec GW, Curtis J, Messenger J. Lower Hospital Volume Is Associated With Higher In-Hospital Mortality in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2013, 6: 659-667. PMID: 24192572, DOI: 10.1161/circoutcomes.113.000233.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIHigh-volume hospitalsLow-volume hospitalsPercutaneous coronary interventionBalloon timeCoronary interventionHospital volumeHigher annual hospital volumeHigher In-Hospital MortalityAnnual hospital volumeLow hospital volumeRoutine coronary stentingIn-Hospital MortalityElevation myocardial infarctionMajority of patientsNew pharmacological agentsHospital mortalityCathPCI RegistryMultivariate adjustmentUnadjusted mortalityCoronary stentingMyocardial infarctionCurrent guidelinesPatient visitsDoor-to-Balloon Time and Mortality among Patients Undergoing Primary PCI
Menees DS, Peterson ED, Wang Y, Curtis JP, Messenger JC, Rumsfeld JS, Gurm HS. Door-to-Balloon Time and Mortality among Patients Undergoing Primary PCI. New England Journal Of Medicine 2013, 369: 901-909. PMID: 24004117, DOI: 10.1056/nejmoa1208200.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIST-segment elevation myocardial infarctionElevation myocardial infarctionBalloon timeHospital mortalityMyocardial infarctionNational quality improvement initiativePercentage of patientsPercutaneous coronary interventionQuality improvement initiativesMedicare data setSignificant overall changeCathPCI RegistryCoronary interventionMedian doorSubgroup analysis
2012
The Prevalence and Outcomes of Transradial Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Analysis From the National Cardiovascular Data Registry (2007 to 2011)
Baklanov DV, Kaltenbach LA, Marso SP, Subherwal SS, Feldman DN, Garratt KN, Curtis JP, Messenger JC, Rao SV. The Prevalence and Outcomes of Transradial Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Analysis From the National Cardiovascular Data Registry (2007 to 2011). Journal Of The American College Of Cardiology 2012, 61: 420-426. PMID: 23265340, PMCID: PMC3883049, DOI: 10.1016/j.jacc.2012.10.032.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryBlood Loss, SurgicalComparative Effectiveness ResearchDrug-Eluting StentsElectrocardiographyFemaleFemoral ArteryHospital MortalityHumansIntraoperative CareMaleMiddle AgedMyocardial InfarctionOutcome and Process Assessment, Health CarePrevalenceRadial ArteryRegistriesRisk FactorsTime-to-TreatmentTreatment OutcomeUnited StatesConceptsST-segment elevation myocardial infarctionPercutaneous coronary interventionTransradial percutaneous coronary interventionHospital mortalityBalloon timeTransradial PCICoronary interventionProcedural successFemoral approachRadial accessFemoral-access percutaneous coronary interventionNational Cardiovascular Data RegistryLonger median doorPost-PCI bleedingElevation myocardial infarctionLarge national databaseLow bleeding ratesCathPCI RegistryVascular complicationsLonger doorMedian doorFemoral accessMyocardial infarctionBleeding rateAccess site
2011
Improvements in Door-to-Balloon Time in the United States, 2005 to 2010
Krumholz HM, Herrin J, Miller LE, Drye EE, Ling SM, Han LF, Rapp MT, Bradley EH, Nallamothu BK, Nsa W, Bratzler DW, Curtis JP. Improvements in Door-to-Balloon Time in the United States, 2005 to 2010. Circulation 2011, 124: 1038-1045. PMID: 21859971, PMCID: PMC3598634, DOI: 10.1161/circulationaha.111.044107.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPercutaneous coronary interventionBalloon timeCoronary interventionMedian timeST-segment elevation myocardial infarctionHigher median timeCharacteristics of patientsPercentage of patientsTimeliness of treatmentYears of ageRegistry studyMyocardial infarctionInpatient measuresPatientsHospital groupMedicaid ServicesCalendar yearInterventionMinutesMedianGroupYearsPercentageInfarction
2009
National Efforts to Improve Door-to-Balloon Time Results From the Door-to-Balloon Alliance
Bradley EH, Nallamothu BK, Herrin J, Ting HH, Stern AF, Nembhard IM, Yuan CT, Green JC, Kline-Rogers E, Wang Y, Curtis JP, Webster TR, Masoudi FA, Fonarow GC, Brush JE, Krumholz HM. National Efforts to Improve Door-to-Balloon Time Results From the Door-to-Balloon Alliance. Journal Of The American College Of Cardiology 2009, 54: 2423-2429. PMID: 20082933, DOI: 10.1016/j.jacc.2009.11.003.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionD2B AllianceBalloon (D2B) AllianceHospital presentationD2B timeNational Cardiovascular Data Registry CathPCI RegistryPrimary percutaneous coronary interventionElevation myocardial infarctionPercutaneous coronary interventionLikelihood of patientsCathPCI RegistryCoronary interventionBalloon timeMyocardial infarctionAmerican CollegePatientsHospitalLongitudinal studyNational Quality CampaignOne-halfPresentationMinNational effortsInfarctionRegistryAssociation of Door-to-Balloon Time and Mortality in Patients ≥65 Years With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Rathore SS, Curtis JP, Nallamothu BK, Wang Y, Foody JM, Kosiborod M, Masoudi FA, Havranek EP, Krumholz HM. Association of Door-to-Balloon Time and Mortality in Patients ≥65 Years With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. The American Journal Of Cardiology 2009, 104: 1198-1203. PMID: 19840562, PMCID: PMC2790921, DOI: 10.1016/j.amjcard.2009.06.034.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIST-elevation myocardial infarctionPercutaneous coronary interventionBalloon timeMyocardial infarctionCoronary interventionAssociation of doorMinutes of admissionSecond-degree fractional polynomialsLogistic regression analysisFractional polynomial modelsMultivariable adjustmentLonger doorMedian doorCurrent guidelinesPatientsMortalityInfarctionRegression analysisFractional polynomialsAssociationInterventionMinutesTreatmentAssociation of door-to-balloon time and mortality in patients admitted to hospital with ST elevation myocardial infarction: national cohort study
Rathore SS, Curtis JP, Chen J, Wang Y, Nallamothu BK, Epstein AJ, Krumholz HM, Registry F. Association of door-to-balloon time and mortality in patients admitted to hospital with ST elevation myocardial infarction: national cohort study. The BMJ 2009, 338: b1807. PMID: 19454739, PMCID: PMC2684578, DOI: 10.1136/bmj.b1807.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-elevation myocardial infarctionElevation myocardial infarctionPercutaneous coronary interventionBalloon timeCoronary interventionMyocardial infarctionCohort studyLower mortalityMultivariable logistic regression modelAssociation of doorIncremental mortality benefitProspective cohort studyNational cohort studyAcute care hospitalsLogistic regression modelsFractional polynomial modelsAdjusted riskLonger doorMedian doorMortality benefitCare hospitalOverall mortalityMAIN OUTCOMEAmerican College
2008
Delay in Presentation and Reperfusion Therapy in ST-Elevation Myocardial Infarction
Ting HH, Bradley EH, Wang Y, Nallamothu BK, Gersh BJ, Roger VL, Lichtman JH, Curtis JP, Krumholz HM. Delay in Presentation and Reperfusion Therapy in ST-Elevation Myocardial Infarction. The American Journal Of Medicine 2008, 121: 316-323. PMID: 18374691, PMCID: PMC2373574, DOI: 10.1016/j.amjmed.2007.11.017.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, Balloon, CoronaryEarly DiagnosisElectrocardiographyEmergency Medical ServicesEmergency Service, HospitalFemaleFollow-Up StudiesHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionMyocardial RevascularizationOdds RatioProbabilityRegistriesRetrospective StudiesRisk FactorsSurvival AnalysisThrombolytic TherapyTime FactorsTreatment OutcomeConceptsST-elevation myocardial infarctionReperfusion therapyHospital presentationBalloon timeSymptom onsetLonger doorMyocardial infarctionDrug timePrimary reperfusion therapyCohort studyLate presentersNeedle timeNational registryPatientsReduced likelihoodTherapyInfarctionLong delayPresentationOnsetHoursAssociationMinutesRegistry
2007
Comparing Hospital Performance in Door-to-Balloon Time Between the Hospital Quality Alliance and the National Cardiovascular Data Registry
Nallamothu BK, Wang Y, Bradley EH, Ho KK, Curtis JP, Rumsfeld JS, Masoudi FA, Krumholz HM. Comparing Hospital Performance in Door-to-Balloon Time Between the Hospital Quality Alliance and the National Cardiovascular Data Registry. Journal Of The American College Of Cardiology 2007, 50: 1517-1519. PMID: 17919575, DOI: 10.1016/j.jacc.2007.07.010.Peer-Reviewed Original ResearchSummary of Evidence Regarding Hospital Strategies to Reduce Door-to-Balloon Times for Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Bradley EH, Nallamothu BK, Curtis JP, Webster TR, Magid DJ, Granger CB, Moscucci M, Krumholz HM. Summary of Evidence Regarding Hospital Strategies to Reduce Door-to-Balloon Times for Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. Critical Pathways In Cardiology A Journal Of Evidence-Based Medicine 2007, 6: 91-97. PMID: 17804968, DOI: 10.1097/hpc.0b013e31812da7bc.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionPercutaneous coronary interventionBalloon timeCoronary interventionCross-sectional designMyocardial infarctionCatheterization laboratoryPrompt percutaneous coronary interventionPrimary percutaneous coronary interventionHospital-based strategiesEmergency medicine physiciansHospital strategiesSummary of evidenceRandomized trialsPrehospital electrocardiogramCatheterization teamObservational studyMedicine physiciansClinical importanceComputerized searchPatientsEffective interventionsHospitalHospital efforts
2006
Strategies for Reducing the Door-to-Balloon Time in Acute Myocardial Infarction
Bradley EH, Herrin J, Wang Y, Barton BA, Webster TR, Mattera JA, Roumanis SA, Curtis JP, Nallamothu BK, Magid DJ, McNamara RL, Parkosewich J, Loeb JM, Krumholz HM. Strategies for Reducing the Door-to-Balloon Time in Acute Myocardial Infarction. New England Journal Of Medicine 2006, 355: 2308-2320. PMID: 17101617, DOI: 10.1056/nejmsa063117.Peer-Reviewed Original ResearchConceptsST-segment elevationBalloon timeCatheterization laboratoryMyocardial infarctionFaster doorEmergency departmentPrimary percutaneous coronary interventionHospital strategiesIntracoronary balloon inflationPercutaneous coronary interventionAcute myocardial infarctionMinority of hospitalsEmergency medicine physiciansReperfusion treatmentCoronary interventionBalloon inflationMedicine physiciansMultivariate analysisHospitalInfarctionPatientsMedicaid ServicesSignificant reductionReal-time data feedbackData feedbackEffect of Door-to-Balloon Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction
McNamara RL, Wang Y, Herrin J, Curtis JP, Bradley EH, Magid DJ, Peterson ED, Blaney M, Frederick PD, Krumholz HM, Investigators N. Effect of Door-to-Balloon Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction. Journal Of The American College Of Cardiology 2006, 47: 2180-2186. PMID: 16750682, DOI: 10.1016/j.jacc.2005.12.072.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-segment elevation myocardial infarctionBalloon timeElevation myocardial infarctionSymptom onsetMyocardial infarctionHospital mortalityPatient characteristicsDoor timeEffect of doorPrimary PCIBaseline risk statusPercutaneous coronary interventionHigh-risk factorsSTEMI patientsCohort studyCoronary interventionLonger doorEntire cohortSubgroup analysisNational registryBaseline riskMortality riskPatientsMortalityThe Pre-Hospital Electrocardiogram and Time to Reperfusion in Patients With Acute Myocardial Infarction, 2000–2002 Findings From the National Registry of Myocardial Infarction-4
Curtis JP, Portnay EL, Wang Y, McNamara RL, Herrin J, Bradley EH, Magid DJ, Blaney ME, Canto JG, Krumholz HM. The Pre-Hospital Electrocardiogram and Time to Reperfusion in Patients With Acute Myocardial Infarction, 2000–2002 Findings From the National Registry of Myocardial Infarction-4. Journal Of The American College Of Cardiology 2006, 47: 1544-1552. PMID: 16630989, DOI: 10.1016/j.jacc.2005.10.077.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPre-hospital electrocardiogramPrimary percutaneous coronary interventionMyocardial infarction 4Mean doorReperfusion timeHospital characteristicsNational registryTreatment of STEMILimited contemporary informationElevation myocardial infarctionPercutaneous coronary interventionBundle branch blockAcute reperfusionECG usePCI cohortReperfusion therapyBalloon timeCoronary interventionFibrinolytic therapyTherapy cohortMyocardial infarctionBranch blockNational guidelinesDrug time
2005
Hospital Improvement in Time to Reperfusion in Patients With Acute Myocardial Infarction, 1999 to 2002
McNamara RL, Herrin J, Bradley EH, Portnay EL, Curtis JP, Wang Y, Magid DJ, Blaney M, Krumholz HM, Investigators N. Hospital Improvement in Time to Reperfusion in Patients With Acute Myocardial Infarction, 1999 to 2002. Journal Of The American College Of Cardiology 2005, 47: 45-51. PMID: 16386663, PMCID: PMC1475926, DOI: 10.1016/j.jacc.2005.04.071.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionBalloon timeMin/yearNeedle timeMyocardial infarctionHospital characteristicsAcute ST-segment elevation myocardial infarctionPercutaneous coronary intervention cohortPercutaneous coronary intervention volumeElevation myocardial infarctionPercutaneous coronary interventionRetrospective observational studyFour-year study periodRapid reperfusionCoronary interventionFibrinolytic therapyHospital arrivalTherapy cohortReperfusion timeIntervention cohortNational registryIntervention volumeObservational studyHospital improvementPatientsRelationship Between Time of Day, Day of Week, Timeliness of Reperfusion, and In-Hospital Mortality for Patients With Acute ST-Segment Elevation Myocardial Infarction
Magid DJ, Wang Y, Herrin J, McNamara RL, Bradley EH, Curtis JP, Pollack CV, French WJ, Blaney ME, Krumholz HM. Relationship Between Time of Day, Day of Week, Timeliness of Reperfusion, and In-Hospital Mortality for Patients With Acute ST-Segment Elevation Myocardial Infarction. JAMA 2005, 294: 803-812. PMID: 16106005, DOI: 10.1001/jama.294.7.803.Peer-Reviewed Original ResearchMeSH KeywordsAdultAfter-Hours CareAgedAged, 80 and overAngioplasty, Balloon, CoronaryBenchmarkingChronology as TopicFemaleHospital MortalityHospitalsHumansMaleMiddle AgedMyocardial InfarctionMyocardial ReperfusionRegistriesRetrospective StudiesThrombolytic TherapyTime and Motion StudiesTime FactorsUnited StatesUtilization ReviewConceptsST-segment elevation myocardial infarctionPercutaneous coronary interventionElevation myocardial infarctionBalloon timeFibrinolytic therapyHospital mortalityMyocardial infarctionAcute ST-segment elevation myocardial infarctionDrug timeRegular hoursTimeliness of reperfusionIn-Hospital MortalityDay of weekPCI patientsReperfusion therapyCohort studyCoronary interventionMean doorHospital characteristicsCatheterization laboratoryBetter outcomesPatientsHospital subgroupsTherapyPatient arrival