Jennifer Loza
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Nikhil Joshi Lab
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About
Biography
Jennifer is a doctoral student in the Department of Immunobiology, under the mentorship of Dr. Nikhil Joshi. Her thesis project is focused on understanding how cancer escapes the immune system during early-tumor development and through resistance to checkpoint blockade therapy. Specifically, how neoantigen heterogeneity amongst cancer cells impacts escape of T cell immunosurveillance. Her goal is to discover immunoediting pathways that tumors exploit to evade T cell control, identifying targets for the development of novel anti-cancer drugs.
She received her Bachelor of Science in Biochemistry and Cell Biology with a minor in Psychology from the University of California, San Diego (UCSD), earning her degree with honors distinction. She started doing research in centrosome biology, studying mechanisms of cell division in C. elegans in the Oegema/Desai Lab during her undergrad at UCSD. Jennifer also completed a senior thesis project in Dr. Enfu Hui's lab, studying the structural components of the immune checkpoint molecule, PD-1. She gained an interest in biochemical techniques and intravital imaging through her undergraduate research experience.
She is currently a trainee under the Yale Cancer Biology Training Grant for predoctoral students. She is also the Director the Yale Biological and Biomedical Sciences Diversity and Inclusion Collective (YBDIC). As a first-generation Mexican American scholar, Jennifer strives to empower historically-underrepresented students in science.
Education & Training
- BS (Hon)
- University of California, San Diego (2021)
Research
Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0003-4200-394X- View Lab Website
Nikhil Joshi Lab
Research at a Glance
Yale Co-Authors
Research Interests
Jonathan Leventhal, MD
Nikhil Joshi, PhD
Smita Krishnaswamy, PhD
Srividhya Venkatesan
William Damsky, MD, PhD
Publications
2023
PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens
Damo M, Hornick N, Venkat A, William I, Clulo K, Venkatesan S, He J, Fagerberg E, Loza J, Kwok D, Tal A, Buck J, Cui C, Singh J, Damsky W, Leventhal J, Krishnaswamy S, Joshi N. PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens. Nature 2023, 619: 151-159. PMID: 37344588, PMCID: PMC10989189, DOI: 10.1038/s41586-023-06217-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEffector CD8 T cellsCD8 T cellsAntigen-specific effector CD8 T cellsAntigen-specific CD8 T cellsAntigen-expressing cellsT cell tolerancePD-1T cellsAdverse eventsCell toleranceCD8 T cell toleranceImmune-related adverse eventsPeripheral T cell repertoirePeripheral T cell toleranceNon-lesional skinT cell repertoireT-cell antigensPeripheral toleranceCheckpoint receptorsSkin biopsiesLocal infiltrationLocal pathologyCell repertoireMouse modelSkin tolerance
Academic Achievements & Community Involvement
activity Yale BBS Diversity and Inclusion Collective
Professional OrganizationsDirectorDetailsThe Yale BBS Diversity and Inclusion Collective (YBDIC) promotes the recruitment, retention, and inclusion of graduate students in the Yale Biological and Biomedical Sciences Program who belong to historically underrepresented, marginalized, and disadvantaged backgrounds. I am the current Graduate Director for the 2024-2025 school year, previously serving as a fellow and chair of the Advancement branch.06/01/2022 - Present
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Contacts
Locations
Nikhil Joshi Lab
Lab
The Anlyan Center
300 Cedar Street
New Haven, CT 06519
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