2024
Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors
Kwan J, Shen M, Akhlaghi N, Hu J, Mora R, Cross J, Jiang M, Mankbadi M, Wang P, Zaman S, Lee S, Im Y, Feher A, Liu Y, S. S, Tao W, Wei W, Baldassarre L. Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors. PLOS ONE 2024, 19: e0314555. PMID: 39621799, PMCID: PMC11611253, DOI: 10.1371/journal.pone.0314555.Peer-Reviewed Original ResearchConceptsAdverse cardiovascular eventsICI therapyCardiac magnetic resonanceIncreased risk of mortalityICI initiationIncreased riskRisk of mortalityCentral nervous systemVentricular dysfunctionCancer patients treated with ICIsCardiovascular eventsLeft ventricular late gadolinium enhancementMortality benefitCardiovascular riskAbnormal left ventricular ejection fractionPatients treated with ICIsLeft ventricular ejection fractionCentral nervous system malignanciesRisk of adverse cardiovascular eventsImmune checkpoint inhibitorsRight ventricular dysfunctionGlobal longitudinal strainVentricular ejection fractionLeft ventricular dysfunctionMultimodality cardiac imagingDiastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e’: Comparison to echocardiography
Lamy J, Xiang J, Shah N, Kwan J, Kim Y, Upadhyaya K, Reinhardt S, Meadows J, McNamara R, Baldassarre L, Peters D. Diastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e’: Comparison to echocardiography. Physiological Reports 2024, 12: e70078. PMID: 39604208, PMCID: PMC11602526, DOI: 10.14814/phy2.70078.Peer-Reviewed Original ResearchConceptsCardiovascular magnetic resonanceTransthoracic echocardiographyDiastolic dysfunctionDiastolic functionDiagnostic accuracy of cardiovascular magnetic resonanceEvaluate diastolic dysfunctionCardiovascular magnetic resonance imagingLeft atrial volumeMitral annular velocityHealthy age-matched subjectsComparison to echocardiographyMitral inflow velocityEvaluate diastolic functionAge-matched subjectsPresence of DDAtrial volumeDD gradeFirst-lineAnnular velocityDiagnostic accuracyImaging modalitiesMagnetic resonanceEchocardiographyALLTransthoracicClonal hematopoiesis of indeterminate potential is associated with increased risk of immune checkpoint inhibitor myocarditis in a prospective study of a cardio-oncology cohort
Jaber Chehayeb R, Singh J, Matute-Martinez C, Chen N, Guajardo A, Lin D, Jayakrishnan R, Christofides A, Leveille E, Im Y, Biancon G, VanOudenhove J, Ibrahim E, Ardasheva A, Jha A, Hwa J, Halene S, Kwan J. Clonal hematopoiesis of indeterminate potential is associated with increased risk of immune checkpoint inhibitor myocarditis in a prospective study of a cardio-oncology cohort. Cardio-Oncology 2024, 10: 84. PMID: 39587635, PMCID: PMC11590368, DOI: 10.1186/s40959-024-00289-z.Peer-Reviewed Original ResearchImmune checkpoint inhibitor myocarditisImmune checkpoint inhibitorsImmune checkpoint inhibitor useICI-myocarditisIndeterminate potentialProspective studyImmune checkpoint inhibitor therapyCancer therapyClonal hematopoiesis of indeterminate potentialCancer treated with immunotherapyIncreased T cell activationObstructive coronary artery diseaseMultivariate competing risk analysisCardiotoxic cancer therapyRisks Cox regressionAssociated with increased riskIncreased all-cause mortalityPatient co-morbiditiesRisk of cardiomyopathyT cell activationCompeting risk analysisCoronary artery calcificationCoronary artery diseaseAll-cause mortalityHeart failure patientsRetraction notice to Gedatolisib Associated Acute Myocarditis in a Patient With Breast Adenocarcinoma J Am Coll Cardiol. 2024;83(13 Suppl):3575.
Shen M, Khattab M, Akintoye E, Baldassarre L, Kwan J. Retraction notice to Gedatolisib Associated Acute Myocarditis in a Patient With Breast Adenocarcinoma J Am Coll Cardiol. 2024;83(13 Suppl):3575. Journal Of The American College Of Cardiology 2024, 84: 1683. DOI: 10.1016/j.jacc.2024.09.017.Peer-Reviewed Original ResearchRemoved: “Kiosk 8Q-FA-03—Gedatolisib Associated Acute Myocarditis in a Patient with Breast Adenocarcinoma” [Journal of Cardiovascular Magnetic Resonance 26 (2024) 100856]
Khattab M, Kwan J, Alkhatib D, Shen M, Desai S, Akintoye E, Huber S, Baldassarre L. Removed: “Kiosk 8Q-FA-03—Gedatolisib Associated Acute Myocarditis in a Patient with Breast Adenocarcinoma” [Journal of Cardiovascular Magnetic Resonance 26 (2024) 100856]. Journal Of Cardiovascular Magnetic Resonance 2024, 101084. PMID: 39181776, DOI: 10.1016/j.jocmr.2024.101084.Peer-Reviewed Original ResearchSomatic Variants Acquired Later in Life Associated with Thoracic Aortic Aneurysms: JAK2 V617F
Waldron C, Zafar M, Ma D, Zhang H, Dykas D, Ziganshin B, Popa A, Jha A, Kwan J, Elefteriades J. Somatic Variants Acquired Later in Life Associated with Thoracic Aortic Aneurysms: JAK2 V617F. Genes 2024, 15: 883. PMID: 39062663, PMCID: PMC11276600, DOI: 10.3390/genes15070883.Peer-Reviewed Original ResearchThoracic aortic aneurysmDevelopment of thoracic aortic aneurysmAortic aneurysmJAK2 V617FMyeloproliferative neoplasmsSomatic variantsPrevalence of thoracic aortic aneurysmsDescending thoracic aortic aneurysmJAK2 V617F burdenAortic valve diseaseTarget of therapyDriver of myeloproliferative neoplasmsSurgical aortic replacementVariant allele fractionAscending thoracic aortic aneurysmAortic replacementAneurysm sizeAneurysm patientsValve diseaseVariant carriersIncreased riskJAK2 geneExome sequencing databaseAllele fractionAneurysmClonal Hematopoiesis Is Associated With Cardiomyopathy During Solid Tumor Therapy
Leveille E, Cheheyeb R, Matute-Martinez C, Chen N, Jayakrishnan R, Christofides A, Lin D, Im Y, Biancon G, VanOudenhove J, Halene S, Kwan J. Clonal Hematopoiesis Is Associated With Cardiomyopathy During Solid Tumor Therapy. JACC CardioOncology 2024, 6: 605-607. PMID: 39239339, PMCID: PMC11372300, DOI: 10.1016/j.jaccao.2024.05.013.Peer-Reviewed Original ResearchImpact of COVID-19 pandemic on physician-scientist trainees to faculty one year into the pandemic
Obradovic A, Toubat O, Chen N, Siebert A, Jansen C, Christophers B, Leveille E, Noch E, Kwan J. Impact of COVID-19 pandemic on physician-scientist trainees to faculty one year into the pandemic. BMC Medical Education 2024, 24: 587. PMID: 38807106, PMCID: PMC11134762, DOI: 10.1186/s12909-024-05541-9.Peer-Reviewed Original ResearchConceptsPersonal healthLong-term effects of COVID-19Physician-scientist traineesPhysician-scientistsCross-sectional survey of medical studentsCOVID-19 pandemicSurvey of medical studentsClustering techniqueScientific pursuitsHealth of familiesMultivariate regression analysisEffects of COVID-19ConclusionsThis national surveyLevel of trainingTailored supportPhysician-scientist trainingResearch productivityMental healthFewer physiciansLonger-term impactMedical studentsImpaired productionCOVID-19Long-term effectsReport concernsKiosk 8Q-FA-03 Gedatolisib Associated Acute Myocarditis in a Patient with Breast Adenocarcinoma
Khattab M, Kwan J, Alkhatib D, Shen M, Desai S, Akintoye E, Huber S, Baldassarre L. Kiosk 8Q-FA-03 Gedatolisib Associated Acute Myocarditis in a Patient with Breast Adenocarcinoma. Journal Of Cardiovascular Magnetic Resonance 2024, 26: 100856. PMID: 39155091, DOI: 10.1016/j.jocmr.2024.100856.Peer-Reviewed Original ResearchGEDATOLISIB ASSOCIATED ACUTE MYOCARDITIS IN A PATIENT WITH BREAST CANCER
Shen M, Khattab M, Akintoye E, Baldassarre L, Kwan J. GEDATOLISIB ASSOCIATED ACUTE MYOCARDITIS IN A PATIENT WITH BREAST CANCER. Journal Of The American College Of Cardiology 2024, 83: 3575. PMID: 39327001, DOI: 10.1016/s0735-1097(24)05565-7.Peer-Reviewed Original ResearchINSTANT DIGITAL CONSULT FOR EVIDENCE-BASED INTERPRETATION OF HIGH-SENSITIVITY SERUM TROPONIN IN MYOCARDIAL INJURY
Ye Z, Maayah M, Wang P, See C, Grubman S, Akhlaghi N, Allen S, Dong W, Ghare M, Gokhan I, Grubman D, Mezue K, Mottola G, Park D, Trejo-Paredes C, Shen M, Vemmou E, Abdullah A, Alaiwi S, Sharma S, Gupta N, Gandhi P, Wang Y, Kwan J, Hu J. INSTANT DIGITAL CONSULT FOR EVIDENCE-BASED INTERPRETATION OF HIGH-SENSITIVITY SERUM TROPONIN IN MYOCARDIAL INJURY. Journal Of The American College Of Cardiology 2024, 83: 2522. DOI: 10.1016/s0735-1097(24)04512-1.Peer-Reviewed Original ResearchClinical Interpretation of Serum Troponin in the Era of High-Sensitivity Testing
Maayah M, Grubman S, Allen S, Ye Z, Park D, Vemmou E, Gokhan I, Sun W, Possick S, Kwan J, Gandhi P, Hu J. Clinical Interpretation of Serum Troponin in the Era of High-Sensitivity Testing. Diagnostics 2024, 14: 503. PMID: 38472975, PMCID: PMC10930800, DOI: 10.3390/diagnostics14050503.Peer-Reviewed Original ResearchAcute coronary syndromeTn elevationCoronary syndromeTreatment of acute coronary syndromesNon-cardiac etiologyManagement of myocardial injuryEvaluation of patientsHigh-sensitivity assaySerum troponinHighly sensitive testPrognostic implicationsCardiac troponinMyocardial injuryPhysical examMyocardial ischemiaPoor specificityLaboratory dataClinical judgmentClinical interpretationTroponinSyndromeAnalytical sensitivityTN measurementsPresentationElevationClinical Biochemistry of Serum Troponin
Gokhan I, Dong W, Grubman D, Mezue K, Yang D, Wang Y, Gandhi P, Kwan J, Hu J. Clinical Biochemistry of Serum Troponin. Diagnostics 2024, 14: 378. PMID: 38396417, PMCID: PMC10887818, DOI: 10.3390/diagnostics14040378.Peer-Reviewed Original ResearchAcute coronary syndromeFalse negative test resultsPoint of care assayInterpretation of serum levelsNegative test resultsTroponin complexChest painInterpretation of assay resultsSerum levelsClinical workupCoronary syndromeTn assaysMyocardial injuryTest characteristicsClinical settingCare assaysTroponinMeasurement assaysMolecular characteristicsPotential causesAssay resultsAssayMolecular structureFalse resultsConstituent proteinsClinical Outcomes Among Immunotherapy-Treated Patients With Primary Cardiac Soft Tissue Sarcomas: A Multicenter Retrospective Study.
Nassar AH, El-Am E, Denu R, Abou Alaiwi S, El Zarif T, Macaron W, Abdel-Wahab N, Desai A, Smith C, Parikh K, Abbasi M, Bou Farhat E, Williams JM, Collins JD, Al-Hader A, McKay RR, Malvar C, Sabra M, Zhong C, El Alam R, Chehab O, Lima J, Phan M, Dalla Pria HF, Trevino A, Neilan TG, Kwan JM, Ravi V, Deshpande H, Demetri G, Choueiri TK, Naqash AR. Clinical Outcomes Among Immunotherapy-Treated Patients With Primary Cardiac Soft Tissue Sarcomas: A Multicenter Retrospective Study. JACC CardioOncol 2024, 6: 71-79. PMID: 38510282, DOI: 10.1016/j.jaccao.2023.11.007.Peer-Reviewed Original ResearchKiosk 5R-TA-01 Left Atrial Evaluation in Immune Check Point Inhibitor Myocarditis Using Cardiac Magnetic Resonance Imaging and Correlations with Cardiovascular Outcomes
Jeyashanmugaraja G, Kwan J, Shah N, Lamy J, Khattab M, Chehayeb R, Guajardo A, Lin D, Christofides A, Alkhatib D, Martinez C, Im Y, Salem J, Redheuil A, Peters D, Baldassarre L. Kiosk 5R-TA-01 Left Atrial Evaluation in Immune Check Point Inhibitor Myocarditis Using Cardiac Magnetic Resonance Imaging and Correlations with Cardiovascular Outcomes. Journal Of Cardiovascular Magnetic Resonance 2024, 26: 100677. DOI: 10.1016/j.jocmr.2024.100677.Peer-Reviewed Original ResearchKiosk 5R-TB-01 Prospective Evaluation of Immune Checkpoint Inhibitor Myocarditis with Serial Quantitative Cardiovascular Magnetic Resonance and Correlations with Cardiovascular Outcomes
Khattab M, Kwan J, Chehayeb R, Guajardo A, Lin D, Christophides A, Alkhatib D, Martinez C, Shah N, Im Y, Jeyashanmugaraja G, Ragheb E, Higgins A, Redheiul A, Salem J, Peters D, Mohjibian H, Baldassarre L. Kiosk 5R-TB-01 Prospective Evaluation of Immune Checkpoint Inhibitor Myocarditis with Serial Quantitative Cardiovascular Magnetic Resonance and Correlations with Cardiovascular Outcomes. Journal Of Cardiovascular Magnetic Resonance 2024, 26: 100686. DOI: 10.1016/j.jocmr.2024.100686.Peer-Reviewed Original Research
2023
Microfluidic Immuno‐Serolomic Assay Reveals Systems Level Association with COVID‐19 Pathology and Vaccine Protection (Small Methods 10/2023)
Kim D, Biancon G, Bai Z, VanOudenhove J, Liu Y, Kothari S, Gowda L, Kwan J, Buitrago‐Pocasangre N, Lele N, Asashima H, Racke M, Wilson J, Givens T, Tomayko M, Schulz W, Longbrake E, Hafler D, Halene S, Fan R. Microfluidic Immuno‐Serolomic Assay Reveals Systems Level Association with COVID‐19 Pathology and Vaccine Protection (Small Methods 10/2023). Small Methods 2023, 7 DOI: 10.1002/smtd.202370057.Peer-Reviewed Original ResearchImproving Support for Physician Scientists—Mind the (Funding) Gap
Kwan J, Gross C. Improving Support for Physician Scientists—Mind the (Funding) Gap. JAMA Network Open 2023, 6: e2332982. PMID: 37725379, DOI: 10.1001/jamanetworkopen.2023.32982.Peer-Reviewed Original ResearchMicrofluidic Immuno‐Serolomic Assay Reveals Systems Level Association with COVID‐19 Pathology and Vaccine Protection
Kim D, Biancon G, Bai Z, VanOudenhove J, Liu Y, Kothari S, Gowda L, Kwan J, Buitrago‐Pocasangre N, Lele N, Asashima H, Racke M, Wilson J, Givens T, Tomayko M, Schulz W, Longbrake E, Hafler D, Halene S, Fan R. Microfluidic Immuno‐Serolomic Assay Reveals Systems Level Association with COVID‐19 Pathology and Vaccine Protection. Small Methods 2023, 7: e2300594. PMID: 37312418, PMCID: PMC10592458, DOI: 10.1002/smtd.202300594.Peer-Reviewed Original ResearchConceptsB cell depletion therapyAcute COVID infectionAnti-spike IgGHigh-risk patientsCoronavirus disease-19COVID-19 pathologyDepletion therapyVaccine protectionAntibody responseCOVID infectionHematologic malignanciesImmune protectionDisease-19Healthy donorsMultiple time pointsSerology assaysBlood samplesSoluble markersB cellsImmunization strategiesPatientsFunctional deficiencySerological analysisTime pointsClonotype diversityQuantitative cardiovascular magnetic resonance findings and clinical risk factors predict cardiovascular outcomes in breast cancer patients
Kwan J, Arbune A, Henry M, Hu R, Wei W, Nguyen V, Lee S, Lopez-Mattei J, Guha A, Huber S, Bader A, Meadows J, Sinusas A, Mojibian H, Peters D, Lustberg M, Hull S, Baldassarre L. Quantitative cardiovascular magnetic resonance findings and clinical risk factors predict cardiovascular outcomes in breast cancer patients. PLOS ONE 2023, 18: e0286364. PMID: 37252927, PMCID: PMC10228774, DOI: 10.1371/journal.pone.0286364.Peer-Reviewed Original ResearchConceptsBreast cancer patientsSystolic heart failureCardiovascular outcomesCancer patientsHeart failureValvular diseaseStrain abnormalitiesLeft ventricular ejection fraction reductionCancer treatment-related cardiotoxicityCardiovascular magnetic resonance findingsVentricular ejection fraction reductionYale-New Haven HospitalEjection fraction reductionTreatment-related cardiotoxicityAdverse cardiovascular outcomesClinical risk factorsNormal LV functionGlobal longitudinal strainIschemic heart diseaseMagnetic resonance findingsRisk regression modelsNew Haven HospitalSubclinical cardiotoxicityDiastolic dysfunctionStatin use