The tumor suppressor CDKN3 controls mitosis
Nalepa G, Barnholtz-Sloan J, Enzor R, Dey D, He Y, Gehlhausen J, Lehmann A, Park S, Yang Y, Yang X, Chen S, Guan X, Chen Y, Renbarger J, Yang F, Parada L, Clapp W. The tumor suppressor CDKN3 controls mitosis. Journal Of Cell Biology 2013, 201: 997-1012. PMID: 23775190, PMCID: PMC3691455, DOI: 10.1083/jcb.201205125.Peer-Reviewed Original ResearchMeSH KeywordsCDC2 Protein KinaseCentrosomeCyclin BCyclin-Dependent Kinase Inhibitor ProteinsCyclin-Dependent KinasesDual-Specificity PhosphatasesHeLa CellsHumansKinetochoresMass SpectrometryMitosisPhosphorylationRNA InterferenceSignal TransductionConceptsLibrary of small interfering RNAsLocalizes to mitotic centrosomesGenome-wide setNetwork of kinasesSignaling axisMass spectrometry screeningSmall interfering RNAEarly mitosisMitotic exitSubcellular localizationHuman phosphatasesSpindle checkpointMitotic centrosomesSerine 209Normal mitosisCell cycleG1/S transitionCDKN3MitosisTargeted anticancer therapeuticsDown-regulationCdc2CentrosomeAnticancer therapeuticsPhosphatase