2022
Small-quantity lipid-based nutrient supplements, with or without added zinc, do not cause excessive fat deposition in Burkinabe children: results from a cluster-randomized community trial
Abbeddou S, Jimenez E, Hess S, Somé J, Ouédraogo J, Brown K. Small-quantity lipid-based nutrient supplements, with or without added zinc, do not cause excessive fat deposition in Burkinabe children: results from a cluster-randomized community trial. European Journal Of Nutrition 2022, 61: 4107-4120. PMID: 35829783, PMCID: PMC9596589, DOI: 10.1007/s00394-022-02936-6.Peer-Reviewed Original ResearchConceptsSmall-quantity lipid-based nutrient supplementsNon-intervention cohortLipid-based nutrient supplementsIntervention cohortIntervention groupCluster-randomized community trialFat-free mass accretionAdditional zinc supplementationFat depositionTrial registrationThe studyCluster-randomized trial designDispersible tabletsMonths of ageExcessive fat depositionMorbidity treatmentNIC childrenNutrient supplementsBurkinabe childrenUS National InstitutesObesity riskZinc supplementationClinical trialsCommunity trialFat massTrial design
2017
Differing growth responses to nutritional supplements in neighboring health districts of Burkina Faso are likely due to benefits of small-quantity lipid-based nutrient supplements (LNS)
Hess S, Peerson J, Becquey E, Abbeddou S, Ouédraogo C, Somé J, Jimenez E, Ouédraogo J, Vosti S, Rouamba N, Brown K. Differing growth responses to nutritional supplements in neighboring health districts of Burkina Faso are likely due to benefits of small-quantity lipid-based nutrient supplements (LNS). PLOS ONE 2017, 12: e0181770. PMID: 28771493, PMCID: PMC5542440, DOI: 10.1371/journal.pone.0181770.Peer-Reviewed Original ResearchConceptsLipid-based nutrient supplementsSmall-quantity lipid-based nutrient supplementsMorbidity burdenHealth districtZinc supplementation studiesMonths of enrollmentCross-trial differencesCommunity-based trialCommunity health workersAge z-scoreNon-intervention control groupMonths old childrenAge-adjusted changesVillage-based community health workersType of interventionMean LAZMorbidity surveillanceNutrient supplementsBaseline characteristicsDiarrhea treatmentLNS groupMean ageChild morbidityZinc supplementationAnthropometric assessment
2016
Comparison of Preventive and Therapeutic Zinc Supplementation in Young Children in Burkina Faso: A Cluster-Randomized, Community-Based Trial 1–3
Becquey E, Ouédraogo C, Hess S, Rouamba N, Prince L, Ouédraogo J, Vosti S, Brown K. Comparison of Preventive and Therapeutic Zinc Supplementation in Young Children in Burkina Faso: A Cluster-Randomized, Community-Based Trial 1–3. Journal Of Nutrition 2016, 146: 2058-2066. PMID: 27489011, DOI: 10.3945/jn.116.230128.Peer-Reviewed Original ResearchConceptsTherapeutic zinc supplementationPreventive zinc supplementationZinc supplementationNonintervention controlsMalaria incidenceDiarrhea incidenceZinc-deficient populationsPrevalence of diarrheaPlasma zinc concentrationTreatment of diarrheaPrimary outcomeBurkinabe childrenMSC groupLower incidenceNIC groupStudy groupTreatment groupsPrimary analysisControl groupDiarrheaIncidenceSupplementationTrial 1Young childrenFever
2015
Effect of zinc added to a daily small-quantity lipid-based nutrient supplement on diarrhoea, malaria, fever and respiratory infections in young children in rural Burkina Faso: a cluster-randomised trial
Somé J, Abbeddou S, Jimenez E, Hess S, Ouédraogo Z, Guissou R, Vosti S, Ouédraogo J, Brown K. Effect of zinc added to a daily small-quantity lipid-based nutrient supplement on diarrhoea, malaria, fever and respiratory infections in young children in rural Burkina Faso: a cluster-randomised trial. BMJ Open 2015, 5: e007828. PMID: 26362661, PMCID: PMC4567679, DOI: 10.1136/bmjopen-2015-007828.Peer-Reviewed Original ResearchConceptsRespiratory tract infectionsAcute lower respiratory tract infectionSmall-quantity lipid-based nutrient supplementsIncidence of diarrheaLower respiratory tract infectionsUpper respiratory tract infectionLipid-based nutrient supplementsSQ-LNSCluster-randomised trialPlacebo tabletsLongitudinal prevalenceIntervention groupPreventive zinc supplementationFrequency of diarrheaMonths of ageYoung childrenRural Burkina FasoMorbidity surveillanceNutrient supplementsTract infectionsRespiratory infectionsUncomplicated diarrheaZinc supplementationDiarrheaFever
2013
Associations Between Intestinal Mucosal Function and Changes in Plasma Zinc Concentration Following Zinc Supplementation
Wessells K, Hess S, Rouamba N, Ouédraogo Z, Kellogg M, Goto R, Duggan C, Ouédraogo J, Brown K. Associations Between Intestinal Mucosal Function and Changes in Plasma Zinc Concentration Following Zinc Supplementation. Journal Of Pediatric Gastroenterology And Nutrition 2013, 57: 348-355. PMID: 23689263, PMCID: PMC4627695, DOI: 10.1097/mpg.0b013e31829b4e9e.Peer-Reviewed Original ResearchConceptsPlasma Zn concentrationsIntestinal mucosal functionMucosal functionCitrulline concentrationZn supplementationIntestinal function testsPlacebo-controlled trialMalabsorption of fatPlasma citrulline concentrationHealthy children 6Plasma zinc concentrationMonths of agePlacebo groupPlacebo supplementationUrinary lactuloseFunction testsIntestinal permeabilitySupplementation groupZinc supplementationChildren 6Vitamin AZinc absorptionDietary Zn absorptionSupplementationMineral absorption
2012
Intestinal permeability at baseline is negatively associated with change in plasma zinc concentration following short‐term zinc supplementation
Wessells K, Hess S, Ouédraogo Z, Rouamba N, Goto R, Ouédraogo J, Brown K. Intestinal permeability at baseline is negatively associated with change in plasma zinc concentration following short‐term zinc supplementation. The FASEB Journal 2012, 26: 392.2-392.2. DOI: 10.1096/fasebj.26.1_supplement.392.2.Peer-Reviewed Original ResearchPlasma zinc concentrationIntestinal permeabilityShort-term zinc supplementationAltered intestinal permeabilityIntestinal mucosal functionMalabsorption of fatRandomized community trialSubclinical enteropathyPlacebo groupPlacebo supplementationMucosal functionZinc supplementationCommunity trialSupplementation periodChildren 6Study groupSD changeVitamin ASupplementation resultsZinc concentrationsZinc absorptionEnteropathyMineral absorptionGrant funding sourcesBaselineCaregiver Recognition of Childhood Diarrhea, Care Seeking Behaviors and Home Treatment Practices in Rural Burkina Faso: A Cross-Sectional Survey
Wilson S, Ouédraogo C, Prince L, Ouédraogo A, Hess S, Rouamba N, Ouédraogo J, Vosti S, Brown K. Caregiver Recognition of Childhood Diarrhea, Care Seeking Behaviors and Home Treatment Practices in Rural Burkina Faso: A Cross-Sectional Survey. PLOS ONE 2012, 7: e33273. PMID: 22428006, PMCID: PMC3302832, DOI: 10.1371/journal.pone.0033273.Peer-Reviewed Original ResearchConceptsOral rehydration solutionHome treatment practicesTreatment practicesCommunity-based household surveyMultiple logistic regression modelTherapeutic zinc supplementationPresence of diarrheaCare seeking behaviourPublic sector clinicsForm of treatmentHealth care providersFormal health servicesCross-sectional surveyDiarrhea control programsLogistic regression modelsRural Burkina FasoRecent diarrheaDiarrhea episodesChildhood diarrheaClinical criteriaIllness durationHealth districtTreatment recommendationsZinc supplementationIllness recognition
2011
Short-Term Zinc Supplementation with Dispersible Tablets or Zinc Sulfate Solution Yields Similar Positive Effects on Plasma Zinc Concentration of Young Children in Burkina Faso: A Randomized Controlled Trial
Wessells K, Ouédraogo Z, Rouamba N, Hess S, Ouédraogo J, Brown K. Short-Term Zinc Supplementation with Dispersible Tablets or Zinc Sulfate Solution Yields Similar Positive Effects on Plasma Zinc Concentration of Young Children in Burkina Faso: A Randomized Controlled Trial. The Journal Of Pediatrics 2011, 160: 129-135.e3. PMID: 21871635, DOI: 10.1016/j.jpeds.2011.06.051.Peer-Reviewed Original ResearchConceptsPlasma Zn concentrationsPlasma zinc concentrationPlacebo groupZinc supplementationDispersible tabletsShort-term zinc supplementationPlacebo-controlled trialMain outcome measuresYoung childrenMonths of ageControlled TrialsPlacebo solutionChildren 6Outcome measuresSD changeSupplementation resultsZinc concentrationsZinc absorptionMean plusSupplementationBurkina FasoTrialsMonthsSimilar positive effectsAgeThe effect of zinc supplementation, provided as either a liquid ZnSO4 solution or a dispersible tablet, on plasma zinc concentration among young Burkinabé children
Wessells R, Ouédraogo Z, Rouamba N, Hess S, Ouédraogo J, Brown K. The effect of zinc supplementation, provided as either a liquid ZnSO4 solution or a dispersible tablet, on plasma zinc concentration among young Burkinabé children. The FASEB Journal 2011, 25: 236.1-236.1. DOI: 10.1096/fasebj.25.1_supplement.236.1.Peer-Reviewed Original ResearchPlasma zinc concentrationPlacebo groupZinc supplementationZinc supplementsPreventive zinc supplementationDispersible tabletsCause mortalityZinc concentrationsZn concPlacebo solutionChildren 6Study populationDaily supplementSD changeWeight gainZinc deficiencyZn supplementsFurther studiesYoung childrenDifferential changesSupplementationSupplementsChildrenGroupZinc sulfate
2008
Major reduction of malaria morbidity with combined vitamin A and zinc supplementation in young children in Burkina Faso: a randomized double blind trial
Zeba A, Sorgho H, Rouamba N, Zongo I, Rouamba J, Guiguemdë R, Hamer D, Mokhtar N, Ouedraogo J. Major reduction of malaria morbidity with combined vitamin A and zinc supplementation in young children in Burkina Faso: a randomized double blind trial. Nutrition Journal 2008, 7: 7. PMID: 18237394, PMCID: PMC2254644, DOI: 10.1186/1475-2891-7-7.Peer-Reviewed Original ResearchConceptsSupplemented groupZinc supplementationVitamin APlacebo groupMalaria episodesSingle doseRandomized double-blind trialFirst malaria episodeRisk of feverDouble-blind trialPlacebo-controlled trialCases of feverDaily zinc supplementationNormal immune functionRisk of infectionCross-sectional surveyMalaria control strategiesClinical malariaFever episodesMalaria morbidityMalaria casesMalaria parasite detectionImmune functionBlind trialConclusionThese results