2018
Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8
Marie C, Clavairoly A, Frah M, Hmidan H, Yan J, Zhao C, Van Steenwinckel J, Daveau R, Zalc B, Hassan B, Thomas JL, Gressens P, Ravassard P, Moszer I, Martin DM, Lu QR, Parras C. Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e8246-e8255. PMID: 30108144, PMCID: PMC6126750, DOI: 10.1073/pnas.1802620115.Peer-Reviewed Original ResearchConceptsChromatin remodelersProliferation-differentiation balanceNormal developmentChromatin accessibility analysisOligodendrocyte precursor cellsChromatin closingChromatin remodelingChromatin openingTranscriptional repressionGenetic interactionsUncharacterized functionGenetic reprogrammingRisk-associated genesTranscriptional activationKey regulatorNeurodevelopmental defectsPrecursor survivalLineage cellsCHD7RemodelersOligodendrocyte lineage cellsPrecursor cellsGlioma formationBinding profileCHD8
2015
Remyelination by Resident Oligodendrocyte Precursor Cells in a Xenopus laevis Inducible Model of Demyelination
Sekizar S, Mannioui A, Azoyan L, Colin C, Thomas JL, Du Pasquier D, Mallat M, Zalc B. Remyelination by Resident Oligodendrocyte Precursor Cells in a Xenopus laevis Inducible Model of Demyelination. Developmental Neuroscience 2015, 37: 232-242. PMID: 25896276, DOI: 10.1159/000380817.Peer-Reviewed Original Research
2013
Ascl1/Mash1 Promotes Brain Oligodendrogenesis during Myelination and Remyelination
Nakatani H, Martin E, Hassani H, Clavairoly A, Maire CL, Viadieu A, Kerninon C, Delmasure A, Frah M, Weber M, Nakafuku M, Zalc B, Thomas JL, Guillemot F, Nait-Oumesmar B, Parras C. Ascl1/Mash1 Promotes Brain Oligodendrogenesis during Myelination and Remyelination. Journal Of Neuroscience 2013, 33: 9752-9768. PMID: 23739972, PMCID: PMC3892435, DOI: 10.1523/jneurosci.0805-13.2013.Peer-Reviewed Original ResearchConceptsOligodendrocyte precursor cellsNeonatal periodCortical oligodendrocyte precursor cellsOligodendrocyte developmentCortical subventricular zoneSubventricular zone progenitorsMultiple sclerosis lesionsMyelin-forming cellsPostnatal cortexRemyelination processFocal demyelinationCorpus callosumSubventricular zoneOPC differentiationPostnatal brainMouse modelAscl1 functionOligodendrogenesisOPC developmentSclerosis lesionsASCL1 expressionCortical progenitorsRemyelinationProneural transcription factorsOligodendrocytes
2012
Opposing Roles for Hoxa2 and Hoxb2 in Hindbrain Oligodendrocyte Patterning
Miguez A, Ducret S, Di Meglio T, Parras C, Hmidan H, Haton C, Sekizar S, Mannioui A, Vidal M, Kerever A, Nyabi O, Haigh J, Zalc B, Rijli FM, Thomas JL. Opposing Roles for Hoxa2 and Hoxb2 in Hindbrain Oligodendrocyte Patterning. Journal Of Neuroscience 2012, 32: 17172-17185. PMID: 23197710, PMCID: PMC6621859, DOI: 10.1523/jneurosci.0885-12.2012.Peer-Reviewed Original Research
2011
Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube
Di Lullo E, Haton C, Le Poupon C, Volovitch M, Joliot A, Thomas JL, Prochiantz A. Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube. Development 2011, 138: 4991-5001. PMID: 22028031, DOI: 10.1242/dev.066282.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCell DifferentiationCell MovementChick EmbryoExtracellular SpaceEye ProteinsHomeodomain ProteinsNerve Tissue ProteinsNeural TubeOligodendrogliaPaired Box Transcription FactorsParacrine CommunicationPAX6 Transcription FactorProtein TransportRepressor ProteinsStem CellsSubstrate SpecificityTissue DistributionConceptsPrecursor cell migrationPax6 proteinPax6 activityChick embryonic neural tubeNeural tubeCell migrationChick neural tubeOligodendrocyte precursor cell migrationEmbryonic neural tubeHomeoprotein transcription factorOPC migrationGene transfer experimentsEmbryonic polarityTranscription factorsIntercellular transferExtracellular expressionPhysiological importancePax6Visual cortex plasticityProteinFundamental rolePossible roleParacrine effectsExpressionPax6 antibodiesA complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells
Lamprianou S, Chatzopoulou E, Thomas J, Bouyain S, Harroch S. A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 17498-17503. PMID: 21969550, PMCID: PMC3198311, DOI: 10.1073/pnas.1108774108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCell DifferentiationCell ProliferationContactin 1Crystallography, X-RayHumansMiceMice, KnockoutModels, MolecularModels, NeurologicalMultiprotein ComplexesNeural Stem CellsNeurogenesisOligodendrogliaProtein Structure, TertiaryReceptor-Like Protein Tyrosine Phosphatases, Class 5Recombinant ProteinsSolubilityConceptsCarbonic anhydrase-like domainPrecursor cellsReceptor protein tyrosineOligodendrocyte precursor cellsPtprz-deficient miceProtein tyrosineCell adhesion moleculeNeural cell adhesion moleculeBiological roleContactin familyCocrystal structureGlial cell populationsUnknown modulatorsPtprzCentral nervous systemCell populationsCNTN1Structural dataAdhesion moleculesBindsContactin-1CellsMature oligodendrocytesComplexesNervous system
2010
Nitric Oxide Plays a Key Role in Myelination in the Developing Brain
Olivier P, Loron G, Fontaine R, Pansiot J, Dalous J, Thi H, Charriaut-Marlangue C, Thomas J, Mercier J, Gressens P, Baud O. Nitric Oxide Plays a Key Role in Myelination in the Developing Brain. Journal Of Neuropathology & Experimental Neurology 2010, 69: 828-837. PMID: 20613635, DOI: 10.1097/nen.0b013e3181ea5203.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, InhalationAge FactorsAnimalsAnimals, NewbornAntigensBehavioral SymptomsBrainCell ProliferationCentral Nervous SystemDose-Response Relationship, DrugEnzyme InhibitorsExploratory BehaviorFemaleFree Radical ScavengersGene Expression Regulation, DevelopmentalIn Situ Nick-End LabelingKi-67 AntigenMaleMiceMice, Inbred C57BLMyelin Basic ProteinMyelin Proteolipid ProteinNerve Fibers, MyelinatedNerve Tissue ProteinsNeuronsNeuropsychological TestsNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide Synthase Type IIO AntigensOligodendrogliaProteoglycansRatsRats, Sprague-DawleySpace PerceptionSpatial BehaviorStatistics, NonparametricConceptsEndogenous NONitric oxide synthase inhibitor N-nitro-L-arginine methyl esterN-nitro-L-arginine methyl esterL-NAME-treated animalsNitric oxidePerinatal brain damageSubsequent behavioral deficitsCentral nervous system myelinationNeonatal exposureC57BL/6 miceNeonatal periodBrain damagePromising therapyBehavioral deficitsMouse pupsImmature oligodendrocytesPotential new avenuesWhite matterLow dosesProliferative effectMyelination defectsMyelinationTransient increaseINODeleterious effects
2008
A novel role for anosmin‐1 in the adhesion and migration of oligodendrocyte precursors
Bribián A, Esteban P, Clemente D, Soussi‐Yanicostas N, Thomas J, Zalc B, de Castro F. A novel role for anosmin‐1 in the adhesion and migration of oligodendrocyte precursors. Developmental Neurobiology 2008, 68: 1503-1516. PMID: 18814310, DOI: 10.1002/dneu.20678.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntibodiesCell AdhesionCell MovementCells, CulturedChemotactic FactorsCollagenCricetinaeCricetulusEmbryo, MammalianExtracellular Matrix ProteinsFibroblast Growth Factor 2GangliosidesGene Expression Regulation, DevelopmentalMiceNerve Tissue ProteinsOligodendrogliaReceptor, Fibroblast Growth Factor, Type 1RetinaRNA, MessengerStem CellsConceptsOptic nerveOligodendrocyte precursorsEntire optic nerveEmbryonic optic nerveRetinal ganglion cellsAnosmin-1Ganglion cellsPreoptic areaCell adhesion moleculeOPC migrationGrowth factorAdhesion moleculesFGF-2Novel roleGuidance cuesFGFR1Soluble formImpairsCellsECM moleculesNovel effectNerveBlockadeEmbryonic stagesAxons
2006
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain
Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Bréant C, Zalc B, Carmeliet P, Alitalo K, Eichmann A, Thomas JL. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nature Neuroscience 2006, 9: 340-348. PMID: 16462734, DOI: 10.1038/nn1646.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell DifferentiationCells, CulturedEvolution, MolecularIntermediate Filament ProteinsLarvaLateral VentriclesMiceMice, KnockoutMice, TransgenicNerve Growth FactorsNerve Tissue ProteinsNestinNeuronsOligodendrogliaOptic NerveRatsRats, WistarStem CellsVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-3Xenopus laevisConceptsNeural progenitor cellsReceptor VEGFR-3Mouse embryosNeural progenitorsVEGFR-3Progenitor cellsVertebrate embryonic brainBlood vessel defectsOligodendrocyte precursor cellsXenopus laevisAction of VEGFEmbryonic brainVascular endothelial growth factor CVEGF-C knockdownNeural cellsPrecursor cellsVessel defectsFactor CEmbryosGrowth factorProgenitorsCellsProliferation of OPCsVascular systemLymphatic vessels
2005
Oligodendrocyte development in the embryonic brain: the contribution of the plp lineage
Le Bras B, Chatzopoulou E, Heydon K, Martínez S, Ikenaka K, Prestoz L, Spassky N, Zalc B, Thomas JL. Oligodendrocyte development in the embryonic brain: the contribution of the plp lineage. The International Journal Of Developmental Biology 2005, 49: 209-220. PMID: 15906234, DOI: 10.1387/ijdb.041963bl.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedBrainCell MovementChick EmbryoMorphogenesisNerve Tissue ProteinsOligodendrogliaStem Cells
2002
Directional Guidance of Oligodendroglial Migration by Class 3 Semaphorins and Netrin-1
Spassky N, de Castro F, Le Bras B, Heydon K, Quéraud-LeSaux F, Bloch-Gallego E, Chédotal A, Zalc B, Thomas J. Directional Guidance of Oligodendroglial Migration by Class 3 Semaphorins and Netrin-1. Journal Of Neuroscience 2002, 22: 5992-6004. PMID: 12122061, PMCID: PMC6757938, DOI: 10.1523/jneurosci.22-14-05992.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Adhesion MoleculesCell DivisionCell LineCell LineageCell MovementChemotaxisCulture TechniquesDCC ReceptorGlycoproteinsHumansMembrane ProteinsMiceNerve Growth FactorsNerve Tissue ProteinsNetrin ReceptorsNetrin-1Neuropilin-1OligodendrogliaOptic NerveReceptors, Cell SurfaceSemaphorin-3AStem CellsTumor Suppressor ProteinsConceptsOligodendrocyte precursor cellsEmbryonic optic nerveMigration of OPCsOptic nerveNetrin-1Sema 3ANetrin-1 receptorWhite matter tractsSema 3FMyelin-forming cellsColorectal cancerClass 3 semaphorinsLocalization of cellsNerveChemotactic effectNeuropilin-1Multiple fociFunctional migrationPrecursor cellsNetrin familyOligodendroglial migrationSemaphorinsNeural tubeDual effectGuidance cues
2001
Sonic hedgehog-dependent emergence of oligodendrocytes in the telencephalon: evidence for a source of oligodendrocytes in the olfactory bulb that is independent of PDGFRalpha signaling.
Spassky N, Heydon K, Mangatal A, Jankovski A, Olivier C, Queraud-Lesaux F, Goujet-Zalc C, Thomas J, Zalc B. Sonic hedgehog-dependent emergence of oligodendrocytes in the telencephalon: evidence for a source of oligodendrocytes in the olfactory bulb that is independent of PDGFRalpha signaling. Development 2001, 128: 4993-5004. PMID: 11748136, DOI: 10.1242/dev.128.24.4993.Peer-Reviewed Original ResearchConceptsSpinal cordPlatelet-derived growth factor receptorOlfactory bulbOligodendrocyte progenitorsInduction of oligodendrocytesSource of oligodendrocytesAnterior entopeduncular areaMedial ganglionic eminenceExpression of PLPGrowth factor receptorRostral palliumTelencephalic oligodendrocytesGanglionic eminenceVentricular focusOligodendroglial lineageCordRostral telencephalonOligodendrocytesOligodendrocyte lineageFactor receptorVentricular progenitorsTelencephalonMouse telencephalonSonic hedgehogMolecular mechanismsThe Early Steps of Oligodendrogenesis: Insights from the Study of the plp Lineage in the Brain of Chicks and Rodents
Spassky N, Olivier C, Cobos I, LeBras B, Goujet-Zalc C, Martínez S, Zalc B, Thomas J. The Early Steps of Oligodendrogenesis: Insights from the Study of the plp Lineage in the Brain of Chicks and Rodents. Developmental Neuroscience 2001, 23: 318-326. PMID: 11756747, DOI: 10.1159/000048715.Peer-Reviewed Original ResearchConceptsOligodendroglial genesBrain of chicksCentral nervous systemMyelin-forming cellsSpinal cordPrimitive progenitor cellsNervous systemRodent brainOligodendroglial markersOligodendrocyte lineageEmbryonic brainProgenitor cellsBrainOligodendrogenesisCell lineagesProgenitor stageCellsChicksCordExpressionEarly stepsOligodendrocytesMonofocal origin of telencephalic oligodendrocytes in the anterior entopeduncular area of the chick embryo
Olivier C, Cobos I, Villegas E, Spassky N, Zalc B, Martinez S, Thomas J. Monofocal origin of telencephalic oligodendrocytes in the anterior entopeduncular area of the chick embryo. Development 2001, 128: 1757-1769. PMID: 11311157, DOI: 10.1242/dev.128.10.1757.Peer-Reviewed Original ResearchConceptsAnterior entopeduncular areaTelencephalic oligodendrocytesOligodendrocyte progenitor cellsCentral nervous systemMyelin-forming cellsRostrocaudal distributionCaudorostral axisVentricular originNervous systemOligodendroglial cellsChick brainOligodendrocytesOligodendrocyte precursorsOligodendrocyte progenitorsVentricular neuroepitheliumCaudal forebrainEntire telencephalonMigratory propertiesQuail-chick chimerasProgenitor cellsBrainChick embryosCellsOligodendrogenesis
2000
Spatiotemporal development of oligodendrocytes in the embryonic brain
Thomas J, Spassky N, Villegas E, Olivier C, Cobos I, Goujet‐Zalc C, Martínez S, Zalc B. Spatiotemporal development of oligodendrocytes in the embryonic brain. Journal Of Neuroscience Research 2000, 59: 471-476. PMID: 10679785, DOI: 10.1002/(sici)1097-4547(20000215)59:4<471::aid-jnr1>3.0.co;2-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersBrainChick EmbryoChimeraMiceOligodendrogliaRatsReceptor, Platelet-Derived Growth Factor alphaStem CellsConceptsCentral nervous systemOligodendrocyte precursor cellsPrecursor cellsNeural tubeSite of originSubventricular zoneNervous systemVentricular layerOligodendrocyte precursorsFirst neuronsOligodendrocyte progenitorsOligodendrocytesEmbryonic brainRostrocaudal axisLast cell typeQuail-chick chimerasProgenitor cellsRecent dataBrainCell typesMosaic populationProgenitor stageCellsNeurons
1999
Single or multiple oligodendroglial lineages: A controversy
Spassky N, Olivier C, Perez‐Villegas E, Goujet‐Zalc C, Martinez S, Thomas J, Zalc B. Single or multiple oligodendroglial lineages: A controversy. Glia 1999, 29: 143-148. PMID: 10625332, DOI: 10.1002/(sici)1098-1136(20000115)29:2<143::aid-glia7>3.0.co;2-d.Peer-Reviewed Original ResearchEarly Specification of Oligodendrocytes in the Chick Embryonic Brain
Villegas E, Olivier C, Spassky N, Poncet C, Cochard P, Zalc B, Thomas J, Martínez S. Early Specification of Oligodendrocytes in the Chick Embryonic Brain. Developmental Biology 1999, 216: 98-113. PMID: 10588866, DOI: 10.1006/dbio.1999.9438.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell DifferentiationCells, CulturedChick EmbryoGene Expression Regulation, DevelopmentalImmunohistochemistryIn Situ HybridizationMyelin Proteolipid ProteinOligodendrogliaReceptor, Platelet-Derived Growth Factor alphaReverse Transcriptase Polymerase Chain ReactionRNA, Messenger
1998
Multiple Restricted Origin of Oligodendrocytes
Spassky N, Goujet-Zalc C, Parmantier E, Olivier C, Martinez S, Ivanova A, Ikenaka K, Macklin W, Cerruti I, Zalc B, Thomas J. Multiple Restricted Origin of Oligodendrocytes. Journal Of Neuroscience 1998, 18: 8331-8343. PMID: 9763477, PMCID: PMC6792828, DOI: 10.1523/jneurosci.18-20-08331.1998.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta-GalactosidaseBiomarkersBleomycinBrain ChemistryCell DifferentiationCell LineageCells, CulturedCentral Nervous SystemCloning, MolecularDNA-Binding ProteinsDrug Resistance, MicrobialFemaleGene Expression Regulation, DevelopmentalLac OperonMaleMiceMice, TransgenicNeuronsOligodendrogliaReceptors, Platelet-Derived Growth FactorStem CellsTranscription FactorsTransgenes