2017
The Xenopus tadpole: An in vivo model to screen drugs favoring remyelination
Mannioui A, Vauzanges Q, Fini JB, Henriet E, Sekizar S, Azoyan L, Thomas JL, Du Pasquier D, Giovannangeli C, Demeneix B, Lubetzki C, Zalc B. The Xenopus tadpole: An in vivo model to screen drugs favoring remyelination. Multiple Sclerosis Journal 2017, 24: 1421-1432. PMID: 28752787, DOI: 10.1177/1352458517721355.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedAzetidinesBenzyl CompoundsDisease Models, AnimalFemaleLarvaMaleReceptors, LysosphingolipidRemyelinationXenopusConceptsSphingosine-1-phosphate receptor 5Receptor 5Sphingosine-1-phosphate receptor 1Efficacy of siponimodNumber of oligodendrocytesSpontaneous remyelinationMultiple sclerosisOptic nervePromyelinating effectE. coli nitroreductaseRemyelinationDual agonistsVivo modelReceptor 1SiponimodConditional ablationOligodendrocytesXenopus tadpolesVivo screeningCRISPR/Cas9 gene editingVivoCas9 gene editingDemyelinationSclerosisGreen fluorescent protein reporter
2015
Remyelination by Resident Oligodendrocyte Precursor Cells in a Xenopus laevis Inducible Model of Demyelination
Sekizar S, Mannioui A, Azoyan L, Colin C, Thomas JL, Du Pasquier D, Mallat M, Zalc B. Remyelination by Resident Oligodendrocyte Precursor Cells in a Xenopus laevis Inducible Model of Demyelination. Developmental Neuroscience 2015, 37: 232-242. PMID: 25896276, DOI: 10.1159/000380817.Peer-Reviewed Original Research
2011
Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube
Di Lullo E, Haton C, Le Poupon C, Volovitch M, Joliot A, Thomas JL, Prochiantz A. Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube. Development 2011, 138: 4991-5001. PMID: 22028031, DOI: 10.1242/dev.066282.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCell DifferentiationCell MovementChick EmbryoExtracellular SpaceEye ProteinsHomeodomain ProteinsNerve Tissue ProteinsNeural TubeOligodendrogliaPaired Box Transcription FactorsParacrine CommunicationPAX6 Transcription FactorProtein TransportRepressor ProteinsStem CellsSubstrate SpecificityTissue DistributionConceptsPrecursor cell migrationPax6 proteinPax6 activityChick embryonic neural tubeNeural tubeCell migrationChick neural tubeOligodendrocyte precursor cell migrationEmbryonic neural tubeHomeoprotein transcription factorOPC migrationGene transfer experimentsEmbryonic polarityTranscription factorsIntercellular transferExtracellular expressionPhysiological importancePax6Visual cortex plasticityProteinFundamental rolePossible roleParacrine effectsExpressionPax6 antibodies
2005
Oligodendrocyte development in the embryonic brain: the contribution of the plp lineage
Le Bras B, Chatzopoulou E, Heydon K, Martínez S, Ikenaka K, Prestoz L, Spassky N, Zalc B, Thomas JL. Oligodendrocyte development in the embryonic brain: the contribution of the plp lineage. The International Journal Of Developmental Biology 2005, 49: 209-220. PMID: 15906234, DOI: 10.1387/ijdb.041963bl.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedBrainCell MovementChick EmbryoMorphogenesisNerve Tissue ProteinsOligodendrogliaStem Cells