2014
Neural-Specific Deletion of Htra2 Causes Cerebellar Neurodegeneration and Defective Processing of Mitochondrial OPA1
Patterson VL, Zullo AJ, Koenig C, Stoessel S, Jo H, Liu X, Han J, Choi M, DeWan AT, Thomas JL, Kuan CY, Hoh J. Neural-Specific Deletion of Htra2 Causes Cerebellar Neurodegeneration and Defective Processing of Mitochondrial OPA1. PLOS ONE 2014, 9: e115789. PMID: 25531304, PMCID: PMC4274161, DOI: 10.1371/journal.pone.0115789.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBehavior, AnimalBlotting, WesternCell ProliferationCerebellumFemaleGTP PhosphohydrolasesHigh-Temperature Requirement A Serine Peptidase 2MaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaMitochondrial ProteinsNerve DegenerationNeuronsParkinson DiseaseReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSequence DeletionSerine EndopeptidasesSignal TransductionConceptsNeural-specific deletionStriatal neuronal lossPostnatal day 18Days of ageNeuronal lossNeurological symptomsParkinson's diseaseMouse modelParkinsonian phenotypeSystemic effectsMitochondrial Opa1Day 18Premature deathMutant miceNeural contributionsMiceCerebellar neurodegenerationKey moleculesStructural anomaliesAbnormal activityAbnormal morphologyCerebellumDiseaseComplete penetranceDeath
2000
RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao.
Traver S, Bidot C, Spassky N, Baltauss T, De Tand M, Thomas J, Zalc B, Janoueix-Lerosey I, Gunzburg J. RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. Biochemical Journal 2000, 350 Pt 1: 19-29. PMID: 10926822, PMCID: PMC1221220, DOI: 10.1042/0264-6021:3500019.Peer-Reviewed Original ResearchConceptsGTPase activityRap effectorRGS proteinsRas/RapTwo-hybrid systemHeterotrimeric G proteinsRaf-1 kinaseG protein-coupled receptorsSitu hybridization experimentsRap proteinsGTPase Rap2Galpha subunitsHeterotrimeric proteinDeletion analysisDomain sharesRGS14Hybridization experimentsRap2B-RafAlpha subunitG proteinsProteinSitu hybridization studiesCertain cellsHybridization studies