2024
Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells
Geraldo L, Xu Y, Mouthon G, Furtado J, Leser F, Blazer L, Adams J, Zhang S, Zheng L, Song E, Robinson M, Thomas J, Sidhu S, Eichmann A. Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells. Science Translational Medicine 2024, 16: eadn8388. PMID: 39565875, DOI: 10.1126/scitranslmed.adn8388.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalCorneal NeovascularizationDisease Models, AnimalHumansIntercellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLMyeloid CellsNeovascularization, PathologicNerve Tissue ProteinsReceptors, ImmunologicRetinaRetinal NeovascularizationSignal TransductionConceptsOxygen-induced retinopathyPathological ocular neovascularizationCorneal neovascularizationMyeloid cellsOcular neovascularizationHeterogeneous population of myeloid cellsBlood-retina barrier integrityPopulation of myeloid cellsActivation of myeloid cellsMonoclonal antibodiesOcular neovascular diseasesBlinding eye diseaseHuman monoclonal antibodyExtracellular domainMouse model in vivoModel in vivoMAb treatmentMyeloid populationsOIR retinasNeovascular diseasesVision lossEye diseaseSlit-RoboSlit-Robo signalingBlocking antibodies
2008
A novel role for anosmin‐1 in the adhesion and migration of oligodendrocyte precursors
Bribián A, Esteban P, Clemente D, Soussi‐Yanicostas N, Thomas J, Zalc B, de Castro F. A novel role for anosmin‐1 in the adhesion and migration of oligodendrocyte precursors. Developmental Neurobiology 2008, 68: 1503-1516. PMID: 18814310, DOI: 10.1002/dneu.20678.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntibodiesCell AdhesionCell MovementCells, CulturedChemotactic FactorsCollagenCricetinaeCricetulusEmbryo, MammalianExtracellular Matrix ProteinsFibroblast Growth Factor 2GangliosidesGene Expression Regulation, DevelopmentalMiceNerve Tissue ProteinsOligodendrogliaReceptor, Fibroblast Growth Factor, Type 1RetinaRNA, MessengerStem CellsConceptsOptic nerveOligodendrocyte precursorsEntire optic nerveEmbryonic optic nerveRetinal ganglion cellsAnosmin-1Ganglion cellsPreoptic areaCell adhesion moleculeOPC migrationGrowth factorAdhesion moleculesFGF-2Novel roleGuidance cuesFGFR1Soluble formImpairsCellsECM moleculesNovel effectNerveBlockadeEmbryonic stagesAxonsStructural Requirement of TAG-1 for Retinal Ganglion Cell Axons and Myelin in the Mouse Optic Nerve
Chatzopoulou E, Miguez A, Savvaki M, Levasseur G, Muzerelle A, Muriel M, Goureau O, Watanabe K, Goutebroze L, Gaspar P, Zalc B, Karagogeos D, Thomas J. Structural Requirement of TAG-1 for Retinal Ganglion Cell Axons and Myelin in the Mouse Optic Nerve. Journal Of Neuroscience 2008, 28: 7624-7636. PMID: 18650339, PMCID: PMC6670848, DOI: 10.1523/jneurosci.1103-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAxonsCell Adhesion Molecules, NeuronalCells, CulturedContactin 2Embryo, MammalianGene Expression Regulation, DevelopmentalLeukocyte L1 Antigen ComplexMiceMice, KnockoutMyelin SheathNerve Tissue ProteinsNeurogliaOptic NerveRetinaRetinal Ganglion CellsTranscription Factor Brn-3AConceptsOptic nerveRetinal ganglion cellsRGC axonsTAG-1Retinal ganglion cell axonsEmbryonic retinal ganglion cellsGanglion cell axonsMouse optic nerveLateral geniculate nucleusWhite matter axonsMyelin-forming cellsPersistent abnormalitiesGanglion cellsGlial cellsCell adhesion moleculeContralateral projectionsGeniculate nucleusCell axonsAstroglial networksRetinal axonsNerveAxonal tractsAxonal caliberMyelination defectsAxons