2024
Complementary and Inducible creERT2 Mouse Models for Functional Evaluation of Endothelial Cell Subtypes in the Bone Marrow
Poulos M, Ramalingam P, Winiarski A, Gutkin M, Katsnelson L, Carter C, Pibouin-Fragner L, Eichmann A, Thomas J, Miquerol L, Butler J. Complementary and Inducible creERT2 Mouse Models for Functional Evaluation of Endothelial Cell Subtypes in the Bone Marrow. Stem Cell Reviews And Reports 2024, 20: 1135-1149. PMID: 38438768, PMCID: PMC11087254, DOI: 10.1007/s12015-024-10703-9.Peer-Reviewed Original ResearchBone marrowEndothelial cellsMouse modelAdult bone marrowArteriole endothelial cellsAdult BMOff-target activityHematopoietic dysfunctionAdult marrowHematopoietic homeostasisEndothelial cell subtypesVascular subtypeCre-expressing lineEndothelial subtypesEndothelial-specificMouse linesHSC activationCell subtypesEC subtypesParacrine signalingPerivascular cellsModulate HSC activationMarrowSubtypesAdult endothelium
2018
The phenotypic and functional properties of mouse yolk-sac-derived embryonic macrophages
Yosef N, Vadakkan TJ, Park JH, Poché RA, Thomas JL, Dickinson ME. The phenotypic and functional properties of mouse yolk-sac-derived embryonic macrophages. Developmental Biology 2018, 442: 138-154. PMID: 30016639, PMCID: PMC6190604, DOI: 10.1016/j.ydbio.2018.07.009.Peer-Reviewed Original ResearchConceptsEmbryonic macrophagesErythro-myeloid progenitorsNeural stem/progenitor cellsExtra-embryonic yolk sacMouse neural stem/progenitor cellsEndothelial cell cord formationStem/progenitor cellsNon-immune functionsEC tube formationDevelopmental processesPrimitive erythroblastsTissue-resident populationsCord formationEarly cellsDirect cellKey inducerProgenitor cellsYolk sacCell contactEssential roleTube formationSpecialized propertiesBone marrowCell maturationProgenitors
2015
Vascular Platform to Define Hematopoietic Stem Cell Factors and Enhance Regenerative Hematopoiesis
Poulos MG, Crowley MJP, Gutkin MC, Ramalingam P, Schachterle W, Thomas JL, Elemento O, Butler JM. Vascular Platform to Define Hematopoietic Stem Cell Factors and Enhance Regenerative Hematopoiesis. Stem Cell Reports 2015, 5: 881-894. PMID: 26441307, PMCID: PMC4649106, DOI: 10.1016/j.stemcr.2015.08.018.Peer-Reviewed Original ResearchConceptsBM endothelial cellsHematopoietic stem cellsBone marrowDevelopment of therapiesAdult bone marrowCytokine profileMyeloablative regimensMyeloablative irradiationStem cell factorRegenerative hematopoiesisPerivascular cellsCellular therapyEndothelial cellsDisease statesCytokine supplementationVascular platformCell factorVascular nicheTherapyPrevious reportsStem cells