2015
Gut Symbionts from Distinct Hosts Exhibit Genotoxic Activity via Divergent Colibactin Biosynthesis Pathways
Engel P, Vizcaino MI, Crawford JM. Gut Symbionts from Distinct Hosts Exhibit Genotoxic Activity via Divergent Colibactin Biosynthesis Pathways. Applied And Environmental Microbiology 2015, 81: 1502-1512. PMID: 25527542, PMCID: PMC4309719, DOI: 10.1128/aem.03283-14.Peer-Reviewed Original ResearchConceptsNonribosomal peptide synthetaseBiosynthetic pathwayBacterial symbiontsGut symbiontsSecondary metabolitesEukaryotic cellsGenomic islandsBacterial gut symbiontDiverse symbiotic associationsDivergent variantsDNA damagePolyketide synthase pathwayE. coliComparative metabolomic analysisRelated secondary metabolitesPathway-dependent mannerSymbiotic associationGene clusterMicrobial interactionsBiosynthesis pathwayDistinct hostsPeptide synthetaseMammalian gutHoney beesSymbionts
2011
NRPS Substrate Promiscuity Diversifies the Xenematides
Crawford JM, Portmann C, Kontnik R, Walsh CT, Clardy J. NRPS Substrate Promiscuity Diversifies the Xenematides. Organic Letters 2011, 13: 5144-5147. PMID: 21888371, PMCID: PMC3184645, DOI: 10.1021/ol2020237.Peer-Reviewed Original Research
2010
Siderophores from Neighboring Organisms Promote the Growth of Uncultured Bacteria
D'Onofrio A, Crawford JM, Stewart EJ, Witt K, Gavrish E, Epstein S, Clardy J, Lewis K. Siderophores from Neighboring Organisms Promote the Growth of Uncultured Bacteria. Cell Chemical Biology 2010, 17: 254-264. PMID: 20338517, PMCID: PMC2895992, DOI: 10.1016/j.chembiol.2010.02.010.Peer-Reviewed Original ResearchConceptsCulturing of organismsUncultured isolatesUncultured bacteriaGrowth factorGrowth promotionCultured microbesCommunity establishmentBacterial speciesSediment biofilmHelper strainSiderophoresCultured organismsOrganismsLack of growthBacteriaPetri dishesSynthetic mediumSame environmentHabitatsIsolatesMicrobesSpeciesGrowthStrainsPromiscuity
2008
Acyl‐Carrier Protein–Phosphopantetheinyltransferase Partnerships in Fungal Fatty Acid Synthases
Crawford JM, Vagstad AL, Ehrlich KC, Udwary DW, Townsend CA. Acyl‐Carrier Protein–Phosphopantetheinyltransferase Partnerships in Fungal Fatty Acid Synthases. ChemBioChem 2008, 9: 1559-1563. PMID: 18551496, PMCID: PMC3189688, DOI: 10.1002/cbic.200700659.Peer-Reviewed Original Research
2006
Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase
Crawford JM, Dancy BC, Hill EA, Udwary DW, Townsend CA. Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 16728-16733. PMID: 17071746, PMCID: PMC1636523, DOI: 10.1073/pnas.0604112103.Peer-Reviewed Original Research