2008
Association of the serotonin transporter polymorphism and obsessive‐compulsive disorder: Systematic review
Bloch MH, Landeros‐Weisenberger A, Sen S, Dombrowski P, Kelmendi B, Coric V, Pittenger C, Leckman JF. Association of the serotonin transporter polymorphism and obsessive‐compulsive disorder: Systematic review. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2008, 147B: 850-858. PMID: 18186076, DOI: 10.1002/ajmg.b.30699.Peer-Reviewed Original ResearchGenes Controlling Affiliative Behavior as Candidate Genes for Autism
Yrigollen CM, Han SS, Kochetkova A, Babitz T, Chang JT, Volkmar FR, Leckman JF, Grigorenko EL. Genes Controlling Affiliative Behavior as Candidate Genes for Autism. Biological Psychiatry 2008, 63: 911-916. PMID: 18207134, PMCID: PMC2386897, DOI: 10.1016/j.biopsych.2007.11.015.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAsperger SyndromeAutistic DisorderBehaviorChildDopamine beta-HydroxylaseFamily HealthFemaleGenetic LinkageGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansMaleOrganizational AffiliationOxytocinProlactinProto-Oncogene Proteins c-fosReceptors, OxytocinReceptors, ProlactinConceptsHeterogeneous genetic factorsAllelic associationCandidate genesAssociation analysisGenetic linkageManifestation of ASDGenesGenetic variantsAllelic variantsFBAT softwareGenetic factorsComplex etiologyIndependent replicationNeurodevelopmental disordersOXTR geneAffiliative behaviorMultiple facetsVariantsPRLRPhenotypeHypothesis
2004
Linkage analysis of ordinal traits for pedigree data
Feng R, Leckman JF, Zhang H. Linkage analysis of ordinal traits for pedigree data. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 16739-16744. PMID: 15548606, PMCID: PMC534720, DOI: 10.1073/pnas.0404623101.Peer-Reviewed Original ResearchConceptsLinkage analysisOrdinal traitsTourette Syndrome Association International ConsortiumLinkage analysis methodsQuantitative traitsEvidence of linkageGenome scanLinkage scanHuman diseasesAllele sharingTraitsPedigree dataInheritance patternDichotomous traitsSignificant allele sharingPhenotypeProportional odds logistic modelGENEHUNTERGenesGeneticsMarkersInternational Consortium
2002
Genomewide Scan of Hoarding in Sib Pairs in Which Both Sibs Have Gilles de la Tourette Syndrome
Zhang H, Leckman JF, Pauls DL, Tsai CP, Kidd KK, Campos MR, Genetics T. Genomewide Scan of Hoarding in Sib Pairs in Which Both Sibs Have Gilles de la Tourette Syndrome. American Journal Of Human Genetics 2002, 70: 896-904. PMID: 11840360, PMCID: PMC379118, DOI: 10.1086/339520.Peer-Reviewed Original ResearchAllelesBehavioral SymptomsChromosomes, HumanChromosomes, Human, Pair 17Chromosomes, Human, Pair 4Chromosomes, Human, Pair 5Gene FrequencyGenetic LinkageGenetic MarkersGenome, HumanHumansMatched-Pair AnalysisNuclear FamilyObsessive-Compulsive DisorderPhenotypeQuantitative Trait, HeritableSoftwareStatistics, NonparametricTourette Syndrome
1994
D2 Dopamine Receptor Alleles Do Not Influence Severity of Tourette's Syndrome: Results From Four Large Kindreds
Gelernter J, Pauls DL, Leckman J, Kidd KK, Kurlan R. D2 Dopamine Receptor Alleles Do Not Influence Severity of Tourette's Syndrome: Results From Four Large Kindreds. JAMA Neurology 1994, 51: 397-400. PMID: 8155017, DOI: 10.1001/archneur.1994.00540160099012.Peer-Reviewed Original ResearchMeSH KeywordsAllelesGenetic LinkageHeterozygoteHomozygoteHumansReceptors, Dopamine D2Severity of Illness IndexTourette Syndrome
1991
Progress in the search for genetic linkage with Tourette syndrome: an exclusion map covering more than 50% of the autosomal genome.
Pakstis AJ, Heutink P, Pauls DL, Kurlan R, van de Wetering BJ, Leckman JF, Sandkuyl LA, Kidd JR, Breedveld GJ, Castiglione CM. Progress in the search for genetic linkage with Tourette syndrome: an exclusion map covering more than 50% of the autosomal genome. American Journal Of Human Genetics 1991, 48: 281-94. PMID: 1990837, PMCID: PMC1683024.Peer-Reviewed Original Research
1990
Gilles de La Tourette's syndrome and some forms of obsessive-compulsive disorder may share a common genetic diathesis.
Leckman JF, Chittenden EH. Gilles de La Tourette's syndrome and some forms of obsessive-compulsive disorder may share a common genetic diathesis. L Encéphale 1990, 16 Spec No: 321-3. PMID: 2209489.Peer-Reviewed Original ResearchConceptsPathophysiology of TSGilles de la Tourette's syndromeObsessive-compulsive disorderLa Tourette's syndromeTourette syndromeOCD patientsCerebrospinal fluid studiesRecent neuropathological studiesEndogenous opioid peptidesMesocortical dopaminergic systemCases of OCDCSF dynorphinNeuropathological studiesCommon genetic diathesisRaphe nucleusBasal gangliaSerotoninergic systemSerotonergic systemClinical studiesDopaminergic systemCommon neural substrateTS patientsNeuropharmacological studiesOpioid peptidesNormal controls