Clonidine in the treatment of Tourette syndrome: a review of data.
Leckman JF, Cohen DJ, Detlor J, Young JG, Harcherik D, Shaywitz BA. Clonidine in the treatment of Tourette syndrome: a review of data. Advances In Neurology 1982, 35: 391-401. PMID: 6756089.Peer-Reviewed Original ResearchConceptsTS patientsLong-term symptomatic improvementPathophysiology of TSDouble-blind trialEfficacy of clonidineMinority of patientsGrowth hormone releasePrimary pathogenic importanceMinimal side effectsSymptomatic improvementBlood pressureProfile of responseNoradrenergic mechanismsMHPG levelsTherapeutic responseHormone releaseClonidinePathogenic importanceAcute dosesSide effectsTourette syndromeBehavioral symptomsPharmacologic investigationsNeurochemical systemsPatientsInteraction of biological and psychological factors in the natural history of Tourette syndrome: a paradigm for childhood neuropsychiatric disorders.
Cohen DJ, Detlor J, Shaywitz BA, Leckman JF. Interaction of biological and psychological factors in the natural history of Tourette syndrome: a paradigm for childhood neuropsychiatric disorders. Advances In Neurology 1982, 35: 31-40. PMID: 6959506.Peer-Reviewed Original Research