2020
Empiric Recurrence Risk Estimates for Chronic Tic Disorders: Implications for Genetic Counseling
Heiman GA, Rispoli J, Seymour C, Leckman JF, King RA, Fernandez TV. Empiric Recurrence Risk Estimates for Chronic Tic Disorders: Implications for Genetic Counseling. Frontiers In Neurology 2020, 11: 770. PMID: 32849224, PMCID: PMC7432137, DOI: 10.3389/fneur.2020.00770.Peer-Reviewed Original ResearchChronic tic disorderRecurrence risk estimatesTic disordersRecurrence riskTourette's disorderRisk estimatesNeuropsychiatric disordersPopulation-based family studyGenetic counselingFirst-degree relativesQuality of lifeFamily studiesVocal ticsPopulation prevalenceFamilial recurrence riskSuch counselingGenetic testingDisordersRiskCounselingEmpiric recurrence riskGenetic variantsRange of risksHeterogeneous genetic architectureComorbidities
2017
A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders
Mataix-Cols D, Frans E, Pérez-Vigil A, Kuja-Halkola R, Gromark C, Isomura K, Fernández de la Cruz L, Serlachius E, Leckman JF, Crowley JJ, Rück C, Almqvist C, Lichtenstein P, Larsson H. A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders. Molecular Psychiatry 2017, 23: 1652-1658. PMID: 29133949, PMCID: PMC5951741, DOI: 10.1038/mp.2017.215.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAutoimmune diseasesChronic tic disorderIndividual autoimmune diseasesThird-degree relativesTic disordersRisk of ADsNational Patient RegisterPatterns of comorbidityFirst-degree relativesPatient RegisterPlacental transmissionNationwide studyBirth cohortCTD casesFamilial clusteringDisordersComorbiditiesPopulation controlsProbandsOCD probandsBiological relativesDiseaseFamilial linkRiskMortality risk in a nationwide cohort of individuals with tic disorders and with tourette syndrome
Meier SM, Dalsgaard S, Mortensen PB, Leckman JF, Plessen KJ. Mortality risk in a nationwide cohort of individuals with tic disorders and with tourette syndrome. Movement Disorders 2017, 32: 605-609. PMID: 28339122, DOI: 10.1002/mds.26939.Peer-Reviewed Original ResearchConceptsTic disordersTourette syndromePremature deathMortality riskProspective cohort studyMortality rate ratiosComorbid attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderExclusion of individualsCohort studyObsessive-compulsive disorderClinical significancePsychiatric disordersPaternal ageSubstance abuseSyndromeHyperactivity disorderDisordersRate ratioDeathRiskCalendar yearAgeIndividualsClinicians
2015
Oxytocin-augmented labor and risk for autism in males
Weisman O, Agerbo E, Carter CS, Harris JC, Uldbjerg N, Henriksen TB, Thygesen M, Mortensen PB, Leckman JF, Dalsgaard S. Oxytocin-augmented labor and risk for autism in males. Behavioural Brain Research 2015, 284: 207-212. PMID: 25707712, DOI: 10.1016/j.bbr.2015.02.028.Peer-Reviewed Original ResearchConceptsSynthetic oxytocinInfant developmentICD-10 DCRSingleton live birthsAugmentation of laborAutistic disorderDose-dependent effectAugment laborMaternal exposureLive birthsModest associationEpidemiological analysisAdverse effectsOxytocinPlausible associationRiskMalesInconsistent findingsDisordersFuture studiesBirthAssociationAutismFindingsAugmentation
1985
Depressives with secondary alcoholism: psychiatric disorders in offspring.
Merikangas KR, Weissman MM, Prusoff BA, Pauls DL, Leckman JF. Depressives with secondary alcoholism: psychiatric disorders in offspring. Journal Of Studies On Alcohol And Drugs 1985, 46: 199-204. PMID: 4010295, DOI: 10.15288/jsa.1985.46.199.Peer-Reviewed Original ResearchConceptsOffspring of probandsSecondary alcoholismMajor depressionGreater riskFivefold greater riskThreefold greater riskOffspring of controlsUnderlying illnessPsychiatric illnessPsychiatric disordersDepressed probandsAlcoholismAnxiety disordersDisordersDepressionFamilial aggregationProbandsRiskIllnessOffspringNumber of parentsAdditional increaseDepressive
1983
Anxiety disorders and depression: contradictions between family study data and DSM-III conventions
Leckman JF, Merikangas KR, Pauls DL, Prusoff BA, Weissman MM. Anxiety disorders and depression: contradictions between family study data and DSM-III conventions. American Journal Of Psychiatry 1983, 140: 880-882. PMID: 6859304, DOI: 10.1176/ajp.140.7.880.Peer-Reviewed Original Research