2013
Chapter Nine Neuroendocrine Aspects of Tourette Syndrome
Martino D, Macerollo A, Leckman JF. Chapter Nine Neuroendocrine Aspects of Tourette Syndrome. International Review Of Neurobiology 2013, 112: 239-279. PMID: 24295624, DOI: 10.1016/b978-0-12-411546-0.00009-3.Peer-Reviewed Original ResearchConceptsTourette syndromeObsessive-compulsive disorderStereotyped behaviorSubgroup of womenAction of testosteroneAnecdotal clinical evidenceDiurnal cortisol rhythmInjection of oxytocinStress steroid hormonesPreliminary evidenceAcute stress responseClinical evidenceAdrenal axisEstrogen levelsExogenous androgensGonadal hormonesCortisol rhythmNormal restorationAnimal modelsAndrogenic steroidsNeuroendocrine aspectsPatientsGender distributionBaseline activityNatural history
2012
Behavioral, Pharmacological, and Immunological Abnormalities after Streptococcal Exposure: A Novel Rat Model of Sydenham Chorea and Related Neuropsychiatric Disorders
Brimberg L, Benhar I, Mascaro-Blanco A, Alvarez K, Lotan D, Winter C, Klein J, Moses AE, Somnier FE, Leckman JF, Swedo SE, Cunningham MW, Joel D. Behavioral, Pharmacological, and Immunological Abnormalities after Streptococcal Exposure: A Novel Rat Model of Sydenham Chorea and Related Neuropsychiatric Disorders. Neuropsychopharmacology 2012, 37: 2076-2087. PMID: 22534626, PMCID: PMC3398718, DOI: 10.1038/npp.2012.56.Peer-Reviewed Original ResearchConceptsSydenham's choreaNeuropsychiatric disordersStreptococcal exposureImmunological abnormalitiesMotor symptomsRat modelAnimal modelsSelective serotonin reuptake inhibitor paroxetineGroup A streptococcal infectionsSerotonin reuptake inhibitor paroxetineSK-N-SH neuronal cellsMale Lewis ratsNovel rat modelNew animal modelCalcium/calmodulin-dependent protein kinase IIRelated neuropsychiatric disordersStreptococcal infectionLewis ratsAntibody depositionBasal gangliaCalmodulin-dependent protein kinase IIDopamine D1GAS antigensGlutamate levelsD2 receptors
2002
An Animal Model of Tourettes Syndrome
Taylor JR, Morshed SA, Parveen S, Mercadante MT, Scahill L, Peterson BS, King RA, Leckman JF, Lombroso PJ. An Animal Model of Tourettes Syndrome. American Journal Of Psychiatry 2002, 159: 657-660. PMID: 11925307, DOI: 10.1176/appi.ajp.159.4.657.Peer-Reviewed Original Research