Effects of Simvastatin and Oral Contraceptive Agent on Polycystic Ovary Syndrome: Prospective, Randomized, Crossover Trial
Banaszewska B, Pawelczyk L, Spaczynski RZ, Dziura J, Duleba AJ. Effects of Simvastatin and Oral Contraceptive Agent on Polycystic Ovary Syndrome: Prospective, Randomized, Crossover Trial. The Journal Of Clinical Endocrinology & Metabolism 2006, 92: 456-461. PMID: 17105841, DOI: 10.1210/jc.2006-1988.Peer-Reviewed Original ResearchConceptsOral contraceptive pillsPolycystic ovary syndromeLow-density lipoprotein cholesterolTotal testosteroneLipoprotein cholesterolOvary syndromeSystemic inflammationCrossover trialSoluble vascular cell adhesion molecule-1Treatment of PCOSVascular cell adhesion molecule-1Ovarian theca-interstitial cellsCell adhesion molecule-1Oral contraceptive agentsSerum total testosteronePrimary outcome measureC-reactive proteinEffect of simvastatinTheca-interstitial cellsAdhesion molecule-1Academic medical centerRandom-effects modelCardiovascular riskFree testosteroneTotal cholesterol