2000
ATP-dependent GSH and glutathioneS-conjugate transport in skate liver: role of an Mrp functional homologue
Rebbeor J, Connolly G, Henson J, Boyer J, Ballatori N. ATP-dependent GSH and glutathioneS-conjugate transport in skate liver: role of an Mrp functional homologue. AJP Gastrointestinal And Liver Physiology 2000, 279: g417-g425. PMID: 10915652, DOI: 10.1152/ajpgi.2000.279.2.g417.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsAnion Transport ProteinsAnionsATP-Binding Cassette TransportersBileBiological TransportCarrier ProteinsCell MembraneEnzyme InhibitorsGlutathioneLiverMaleOxidation-ReductionProtein BindingRatsRats, Sprague-DawleySkates, FishSubstrate SpecificityTaurocholic AcidTritiumConceptsATP-dependent transportLiver membrane vesiclesATP-dependent GSH transportMembrane vesiclesTransport activityATP-independent mechanismGlutathione-conjugate transportFunctional homologueMammalian cellsDNP-SG uptakePlasma membraneHomologous proteinsSkate liverGSH transportLow-affinity pathwayLittle skateMRP familyMultidrug resistance-associated protein 1GSH effluxFunctional assaysProtein 1First direct evidenceProtein bandsDirect evidenceHomologues
1998
Role of glutathione in hepatic bile formation during reperfusion after cold ischemia of the rat liver
Koeppel T, Trauner M, Albert M, Arrese M, Rios-Velez L, Boyer J. Role of glutathione in hepatic bile formation during reperfusion after cold ischemia of the rat liver. Journal Of Hepatology 1998, 28: 812-819. PMID: 9625316, DOI: 10.1016/s0168-8278(98)80231-6.Peer-Reviewed Original ResearchConceptsBiliary glutathione excretionBile duct injuryCold ischemiaBile flowHepatic bile formationDuct injuryLiver transplantationBiliary tractBiliary excretionRat liverGlutathione excretionBasal bile flow ratesBile formationBile acid-independent bile flowOxidative stressLate reperfusion periodBile duct damageBile flow rateOnset of reperfusionIndependent bile flowBile duct morphologyBiliary glutathione concentrationsWistar rat liverLiver reperfusionDuct damageCyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets
Roelofsen H, Soroka C, Keppler D, Boyer J. Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets. Journal Of Cell Science 1998, 111: 1137-1145. PMID: 9512509, DOI: 10.1242/jcs.111.8.1137.Peer-Reviewed Original ResearchConceptsTransport proteinsApical membraneApical domainTransporter-containing vesiclesMultidrug resistance protein 2Protein 2Cell-cell contactMicrotubule-dependent fashionBasolateral plasma membraneApical proteinsEffect of cAMPVesicle trafficAnion transportersSecretory polarityOrganic anion transportersPlasma membraneCanalicular membraneAnion transport capacityTransport activityApical excretionApical poleCanalicular organic anion transportMultispecific organic anion transporterAmphiphilic organic anionsTransport function
1989
Determinants of glutathione efflux and biliary GSH/GSSG ratio in perfused rat liver
Ballatori N, Truong A, K. A, Boyer J. Determinants of glutathione efflux and biliary GSH/GSSG ratio in perfused rat liver. American Journal Of Physiology 1989, 256: g482-g490. PMID: 2564253, DOI: 10.1152/ajpgi.1989.256.3.g482.Peer-Reviewed Original ResearchConceptsGamma-glutamyl transferase activityO2 deliveryBiliary glutathioneHepatic effluxSinusoidal effluxKrebs-Ringer bicarbonate bufferGlutathione effluxRat liverEfflux of glutathioneGSH/GSSG ratioRed blood cellsPerfusion flow rateFluorocarbon emulsionsBile flowTissue GSHOxygen deliveryTransferase activityAT-125LiverBovine red blood cellsPerfusate compositionBlood cellsBileGSSG levelsGSSG ratio
1988
Altered plasma membrane ion permeability in mercury-induced cell injury: Studies in hepatocytes of elasmobranch Raja erinacea
Ballatori N, Shi C, Boyer J. Altered plasma membrane ion permeability in mercury-induced cell injury: Studies in hepatocytes of elasmobranch Raja erinacea. Toxicology And Applied Pharmacology 1988, 95: 279-291. PMID: 2844008, DOI: 10.1016/0041-008x(88)90164-0.Peer-Reviewed Original ResearchCharacteristics of L-alanine uptake in freshly isolated hepatocytes of elasmobranch Raja erinacea
Ballatori N, Boyer J. Characteristics of L-alanine uptake in freshly isolated hepatocytes of elasmobranch Raja erinacea. American Journal Of Physiology 1988, 254: r801-r808. PMID: 3364608, DOI: 10.1152/ajpregu.1988.254.5.r801.Peer-Reviewed Original ResearchConceptsNeutral amino acid transport systemElasmobranch Raja erinaceaMajor gluconeogenic precursorMM alanineSodium-dependent systemAmino acid transport systemsRaja erinaceaHepatic uptakeHepatic concentrationsAcid transport systemL-alanine uptakeAminotransferase activityTumor cellsSpecific transport mechanismsMeAIB transportGluconeogenic precursorsSaturable mechanismSkate hepatocytesHepatocytesAlanine metabolismGlucose releaseMeAIBHepatocyte suspensionsRat hepatocytesUptakeBiliary catabolism of glutathione and differential reabsorption of its amino acid constituents
Ballatori N, Jacob R, Barrett C, Boyer J. Biliary catabolism of glutathione and differential reabsorption of its amino acid constituents. American Journal Of Physiology 1988, 254: g1-g7. PMID: 2892423, DOI: 10.1152/ajpgi.1988.254.1.g1.Peer-Reviewed Original ResearchConceptsGuinea pigsBile samplesAT-125Biliary glutathione excretionControl bile samplesHepatic gamma-glutamyltransferase activityCatabolism of glutathioneTotal amino acidsGamma-glutamyltransferase activityBiliary treePentobarbital sodiumBiliary excretionHepatic bileAmino acid conjugationGlutathione excretionRetrograde intrabiliary infusionBileConcentration of glutathioneFree amino acidsTotal glutamateConstituent amino acidsMarked increaseUndetectable levelsAcid conjugationDogs
1986
Slow biliary elimination of methyl mercury in the marine elasmobranchs, Raja erinacea and Squalus acanthias
Ballatori N, Boyer J. Slow biliary elimination of methyl mercury in the marine elasmobranchs, Raja erinacea and Squalus acanthias. Toxicology And Applied Pharmacology 1986, 85: 407-415. PMID: 3764924, DOI: 10.1016/0041-008x(86)90348-0.Peer-Reviewed Original ResearchConceptsMarine elasmobranchsExcretory processesMarine speciesGlutathione biosynthesisDogfish sharkSharksRaja erinaceaMammalsSkateL-buthionineElasmobranchsR-sulfoximineMethyl mercuryFishSpeciesGlutathioneFree-swimming fishBiosynthesisErinaceaSwimming fishSmall fractionSlower rateBile formationSqualusMercury chlorideIntrabiliary glutathione hydrolysis. A source of glutamate in bile.
Ballatori N, Jacob R, Boyer J. Intrabiliary glutathione hydrolysis. A source of glutamate in bile. Journal Of Biological Chemistry 1986, 261: 7860-7865. PMID: 2872220, DOI: 10.1016/s0021-9258(19)57482-8.Peer-Reviewed Original ResearchConceptsGamma-glutamyl transferase activityBiliary excretionRat bileRetrograde intrabiliary infusionAT-125Normal male Sprague-DawleyAdministration of phenolMale Sprague-DawleyNormal rat bileDihydro-5-isoxazoleacetic acidSource of glutamateIntrabiliary infusionRate of excretionDibromphthalein disulfonateBranched chain amino acids valineBiliary treeSprague-DawleyDiethyl maleateBileExcretionTransferase activityGSH secretionLiver cellsMarked decreaseExcretion of glutamate
1970
The effect of sodium taurocholate on the hepatic metabolism of sulfobromophthalein sodium (BSP). The role of bile flow
Boyer J, Scheig R, Klatskin G. The effect of sodium taurocholate on the hepatic metabolism of sulfobromophthalein sodium (BSP). The role of bile flow. Journal Of Clinical Investigation 1970, 49: 206-215. PMID: 5411780, PMCID: PMC322462, DOI: 10.1172/jci106229.Peer-Reviewed Original ResearchConceptsBile salt excretionBSP TmBile flowBile productionBiliary concentrationHepatic metabolismBile saltsBiliary bile salt excretionSalt excretionSulfobromophthalein sodiumSodium taurocholateMug/minSodium taurocholate infusionBile salt infusionBSP transportCholeretic propertiesSaline infusionTaurocholate infusionIndependent factorsConstant infusionHepatic uptakeMumoles/hrInfusionMul/minPeak levels