Ilke Nalbantoglu, MD
Associate Professor of PathologyCards
About
Research
Publications
2026
666 Evolving Use of p53 Immunohistochemistry and Its Impact on Risk Stratification and Practice Patterns in Barrett’s Esophagus: A Multi-Year Institutional Review
Korie U, Nalbantoglu I. 666 Evolving Use of p53 Immunohistochemistry and Its Impact on Risk Stratification and Practice Patterns in Barrett’s Esophagus: A Multi-Year Institutional Review. Laboratory Investigation 2026, 106: 104953. DOI: 10.1016/j.labinv.2025.104953.Peer-Reviewed Original ResearchTransdifferentiation in TSC2-Mutant Metastatic Pancreatic Neuroendocrine Tumor
Rodman C, Gibson J, Nalbantoglu I, Kunz P. Transdifferentiation in TSC2-Mutant Metastatic Pancreatic Neuroendocrine Tumor. JCO Precision Oncology 2026, 10: e2500663. PMID: 41494141, DOI: 10.1200/po-25-00663.Peer-Reviewed Original Research3.3 Small Bowel Disorders: Celiac Disease and Mimics
Nalbantoglu I, Jain D. 3.3 Small Bowel Disorders: Celiac Disease and Mimics. 2026, 197-207. DOI: 10.1016/b978-0-323-82688-4.00063-7.Peer-Reviewed Original ResearchPlasma cell-rich inflammatory infiltratesCombination of clinical featuresSerological testsCeliac diseaseCeliac-specific antibodiesSystemic autoimmune disorderUpper GI symptomsDietary gluten proteinsGluten proteinsBiopsy findingsClinical featuresAutoimmune disordersDifferential diagnosisIntraepithelial lymphocytesInflammatory infiltrateDuodenal biopsiesGI symptomsSystemic diseaseGenetic predispositionIron deficiencyExclusion of glutenHistological changesLamina propriaHyperplastic cryptsWeight loss
2025
Hepatic Granulomas and Granulomatous Hepatitis
Utku C, Nalbantoglu I. Hepatic Granulomas and Granulomatous Hepatitis. Practical Anatomic Pathology 2025, 109-126. DOI: 10.1007/978-3-031-97506-6_8.Peer-Reviewed Original ResearchPrimary biliary cholangitisBiliary cholangitisHepatic granulomasAssociated with hypersensitivity reactionsImmune-mediated disordersAppropriate treatment strategySystemic sarcoidosisExtensive workupDiagnostic challengeNoninfectious etiologiesLaboratory findingsLiver biopsyClinical findingsDifferential diagnosisAdvanced diagnostic toolsNoninfectious causesDiagnostic considerationsTreatment strategiesInfectious causesHistopathological differencesHypersensitivity reactionsInflammatory responseStaining patternGranulomaGranuloma morphologyWilson’s Disease
Nalbantoglu I. Wilson’s Disease. Practical Anatomic Pathology 2025, 31-40. DOI: 10.1007/978-3-031-97506-6_3.Peer-Reviewed Original ResearchRare autosomal recessive disorderWilson's diseaseLaboratory findingsUnexplained liver enzyme elevationsAutosomal recessive disorder of copper metabolismRecessive disorder of copper metabolismDiagnosis of WDLiver enzyme elevationDisorder of copper metabolismCentral nervous systemEnzyme elevationClinical featuresPathological examinationHistological patternDifferential diagnosisHistological findingsClinicopathologic correlationWork-upLiver diseaseHepatolenticular degenerationNervous systemDiagnosisCopper metabolismLiverDiseaseMargin clearance and post‐procedure ablation decrease recurrence risk in endoscopic mucosal resections for Barrett's‐related neoplasia
Bell P, Kaul V, Bittner K, Chen I, Huber A, Sagan O, Chen W, Nalbantoglu I, Gonzalez R. Margin clearance and post‐procedure ablation decrease recurrence risk in endoscopic mucosal resections for Barrett's‐related neoplasia. Histopathology 2025, 87: 856-868. PMID: 40964766, DOI: 10.1111/his.15554.Peer-Reviewed Original ResearchEndoscopic mucosal resectionHighest-grade lesionsLocal disease recurrenceHigh-grade dysplasiaDisease recurrenceRecurrence riskMargin statusTumor buddingMucosal resectionRisk of local disease recurrenceBarrett's-related neoplasiaLow-stage carcinomasLow-grade dysplasiaCancer invasion depthRelationship to recurrenceGlandular neoplasiaBarrett’s-related adenocarcinomaHistopathological factorsLymphovascular invasionMargin clearanceTumor depthPatient ageRetrospective studyLesion depthOesophageal dysplasiaPatterns of sialyl-Lewis X expression predict gastric histopathology
Vargas N, Quiroga A, Chaves J, Bolaños H, Nalbantoglu I, Astaiza C, Wu Y, Sáenz J. Patterns of sialyl-Lewis X expression predict gastric histopathology. Diagnostic Pathology 2025, 20: 76. PMID: 40551130, PMCID: PMC12183862, DOI: 10.1186/s13000-025-01673-8.Peer-Reviewed Original ResearchConceptsChronic atrophic gastritisChronic non-atrophic gastritisGastric pathologyAssociated with chronic atrophic gastritisIntestinal metaplasiaProgression to gastric cancerSLex expressionPre-cancerous lesionsNon-atrophic gastritisGastric pre-cancerous lesionsHistological diagnosisPre-cancerous changesGlandular distributionAntrum biopsiesAdult patientsGastric corpusAtrophic gastritisChronic inflammationGastric cancerHistological markersHistological assessmentGastric histopathologyGastric epitheliumIntroductionGastric cancerBiopsyApobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer
Blanc V, Riordan J, Soleymanjahi S, Nadeau J, Nalbantoglu I, Xie Y, Molitor E, Madison B, Brunt E, Mills J, Rubin D, Ng I, Ha Y, Roberts L, Davidson N. Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer. Journal Of Clinical Investigation 2025, 135: e194717. PMID: 40454486, PMCID: PMC12126243, DOI: 10.1172/jci194717.Peer-Reviewed Original ResearchIdentification of differential epigenetic landscapes in subtypes of appendiceal cancer.
Ladel L, Tan W, Sailo B, Das P, Tyagi A, Nalbantoglu I, Sharma A, Ahuja N. Identification of differential epigenetic landscapes in subtypes of appendiceal cancer. Journal Of Clinical Oncology 2025, 43: 4199-4199. DOI: 10.1200/jco.2025.43.16_suppl.4199.Peer-Reviewed Original ResearchDifferentially Methylated RegionsAppendiceal cancerAdvanced neoplasiaColorectal cancerCpG islandsAppendiceal neoplasmsNormal tissuesMalignant subtypeGenomic dataLow-grade appendiceal mucinous neoplasmEpigenetic landscapeHeterogeneous group of malignanciesPromoter regionAnalysis of CpG islandsAppendiceal mucinous neoplasmGroup of malignanciesNon-neoplastic controlsEnzymatic methyl-seqHypermethylated CpG islandsSingle-base resolutionHypomethylated CpG islandsRare malignancyQ-value cutoffMucinous neoplasmsEpigenetic clustering
2024
Validation of Metallothionein Immunohistochemistry as a Highly Sensitive Screening Test for Wilson Disease
Stokes N, Patil A, Adeyi O, Bhalla A, Brown I, Byrnes K, Calderaro J, Chen D, Chen W, Cooper C, Dhall D, Frankel W, Gooch G, Gonzalez R, Hammer S, Hale G, Lagana S, McKenzie C, Allende D, Moreira R, Nakhleh R, Nalbantoglu I, Pai R, Salomao M, Schaeffer D, Shih A, Shin J, Simoes C, Vij M, Rela M, Xue Y, Yantiss R, Sabatto B, Graham R. Validation of Metallothionein Immunohistochemistry as a Highly Sensitive Screening Test for Wilson Disease. Modern Pathology 2024, 38: 100628. PMID: 39384020, DOI: 10.1016/j.modpat.2024.100628.Peer-Reviewed Original ResearchWilson's diseaseHistological featuresRare autosomal recessive conditionChronic cholestatic diseaseProtean clinical manifestationsEvaluation of patientsAutosomal recessive conditionSensitive screening testCase of WDCost-effective screening toolRoutine histologic sectionsMedian ageNeedle biopsyCholestatic diseasesWD patientsFibrosis stageClinical manifestationsHistopathological patternsATP7B mutationsHistological patternWD diagnosisTissue specimensAssessed patientsImmunohistochemistryMasson's trichrome
Clinical Trials
Current Trials
Wilson Disease Registry
IRB ID1609018429REGRoleSub InvestigatorPrimary Completion Date10/01/2022Recruiting ParticipantsGenderBoth
Clinical Care
Overview
ILKe Nalbantoglu, MD, is a pathologist who specializes in surgical pathology as well as gastrointestinal and liver pathology. She focuses on diagnosing a wide range of diseases by examining tissues and organs related to the digestive tract and liver. Her detailed tissue evaluations help guide treatment decisions in collaboration with other health care professionals.
As an associate professor of pathology at Yale School of Medicine, Dr. Nalbantoglu is involved in clinical and translational research that advances the understanding of disease processes at the cellular level, which contributes to the development of more effective diagnostic techniques. Her main areas of interest are inflammatory diseases of the liver, liver transplant pathology, and unusual inflammatory disorders of the intestine. Her academic role also includes teaching and training the next generation of pathologists. Dr. Nalbantoglu lectures on GI- and liver-related topics nationally and internationally.
Dr. Nalbantoglu received her medical training from Ege University School of Medicine in Turkey, followed by a residency in anatomic and clinical pathology in St. John’s Hospital and Medical Center, and a fellowship in Liver/GI pathology at Emory University.