2001
Is there a role for antenatal TRH therapy for the prevention of neonatal lung disease?
Gross I, Moya F. Is there a role for antenatal TRH therapy for the prevention of neonatal lung disease? Seminars In Perinatology 2001, 25: 406-416. PMID: 11778911, DOI: 10.1053/sper.2001.29032.Peer-Reviewed Original ResearchConceptsAntenatal thyrotropin-releasing hormoneThyrotropin-releasing hormoneRespiratory distress syndromeSurfactant therapyDistress syndromeOxygen dependencyAntenatal glucocorticoid treatmentLight-headed feelingPatent ductus arteriosusRetinopathy of prematurityNeonatal lung diseaseRandomized clinical trialsPituitary-thyroid axisAddition of TRHAntenatal glucocorticoidsGlucocorticoid therapyMaternal therapyNeonatal complicationsTransient complicationsTRH therapyHormone therapyBlood pressureDuctus arteriosusGlucocorticoid treatmentLung disease
1998
Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats
Jacobs H, Bogue C, Pinter E, Wilson C, Warshaw J, Gross I. Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats. Pediatric Research 1998, 44: 99-104. PMID: 9667378, DOI: 10.1203/00006450-199807000-00016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsButyratesButyric AcidDiabetes Mellitus, ExperimentalEmbryonic and Fetal DevelopmentFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxGestational AgeHistone Deacetylase InhibitorsLungOrgan Culture TechniquesPregnancyPregnancy in DiabeticsRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticConceptsLung developmentLung explantsSurfactant apoproteinExperimental animalsLung mRNA levelsElevated levelsEffect of diabetesFetal rat lung explantsLungs of fetusesRat lung explantsEffect of butyrateAntenatal exposureMaternal diabetesMetabolic abnormalitiesStreptozotocin treatmentLower incidenceNormal ratsDiabetesDexamethasoneLevel of expressionRatsTreatment of explantsSodium butyrateMRNA levelsAlters expression
1997
Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn
Roberts J, Fineman J, Morin F, Shaul P, Rimar S, Schreiber M, Polin R, Zwass M, Zayek M, Gross I, Heymann M, Zapol W, Thusu K, Zellers T, Wylam M, Zaslavsky A. Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn. New England Journal Of Medicine 1997, 336: 605-610. PMID: 9032045, DOI: 10.1056/nejm199702273360902.Peer-Reviewed Original ResearchConceptsPersistent pulmonary hypertensionPulmonary vascular resistanceExtracorporeal membrane oxygenationPulmonary hypertensionSystemic oxygenationNitric oxideSevere hypoxemiaVascular resistanceMembrane oxygenationSystemic arterial hypoxemiaSystemic blood pressureLong-term therapyFull-term infantsNumber of deathsSystemic hypotensionArterial hypoxemiaBlood pressureMulticenter studyConventional therapyAlternative therapiesInvasive treatmentNitric oxide groupHypertensionInitial improvementMethemoglobin levels
1993
Combined hormonal therapy for the prevention of respiratory distress syndrome and its consequences.
Moya F, Gross I. Combined hormonal therapy for the prevention of respiratory distress syndrome and its consequences. Seminars In Perinatology 1993, 17: 267-74. PMID: 8140441.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAntenatal steroidsPostnatal surfactantSurfactant therapyPostnatal surfactant therapyRespiratory distress syndromeSteroid therapyHormonal therapyDistress syndromePremature infantsTherapyNumber of centersEnd pointRoutine useSteroidsTRHMaturation profileApparent benefitPatientsInfantsDeathTerms of RDCLDWidespread useSyndromeComparable data
1992
Plasma Thyroid Hormones and Prolactin in Premature Infants and Their Mothers after Prenatal Treatment with Thyrotropin-Releasing Hormone
Ballard P, Ballard R, Creasy R, Padbury J, Polk D, Bracken M, Moya F, Gross I. Plasma Thyroid Hormones and Prolactin in Premature Infants and Their Mothers after Prenatal Treatment with Thyrotropin-Releasing Hormone. Pediatric Research 1992, 32: 673-678. PMID: 1287557, DOI: 10.1203/00006450-199212000-00009.Peer-Reviewed Original ResearchConceptsThyroid hormonesFree thyroxineThyrotropin-releasing hormone treatmentNewborn lung diseaseDoses of TRHMU/LPituitary-thyroid functionPlasma of womenThyrotropin-Releasing HormoneWk of gestationPmol/LPlasma thyroid hormonesCord TSHTRH i.Preterm fetusesCord concentrationsControl infantsPremature infantsPostnatal surgeTRH administrationLung diseaseCord bloodPrenatal treatmentTriiodothyronine levelsHormone treatmentRespiratory disease in very-low-birthweight infants after prenatal thyrotropin-releasing hormone and glucocorticoid
Ballard R, Ballard P, Bracken M, Moya F, Gross I, Creasy K, Padbury J, Polk D. Respiratory disease in very-low-birthweight infants after prenatal thyrotropin-releasing hormone and glucocorticoid. The Lancet 1992, 339: 510-515. PMID: 1346877, DOI: 10.1016/0140-6736(92)90337-3.Peer-Reviewed Original ResearchMeSH KeywordsBetamethasoneChronic DiseaseDouble-Blind MethodDrug Therapy, CombinationFemaleHumansInfant, Low Birth WeightInfant, NewbornInfant, Premature, DiseasesLung DiseasesMalePregnancyPrenatal CareRespiration, ArtificialRespiratory Distress Syndrome, NewbornRisk FactorsThyrotropin-Releasing HormoneConceptsChronic lung diseaseThyrotropin-releasing hormoneRespiratory distress syndromePrenatal thyrotropin-releasing hormoneDistress syndromePostconceptional ageBirthweight infantsLung diseaseSevere respiratory distress syndromeSteroid-alone groupNeonatal respiratory morbidityComplications of prematurityUnadjusted relative riskPrenatal glucocorticoid treatmentWeeks postconceptional ageTRH therapyPreterm deliveryRespiratory morbidityWeeks' gestationGlucocorticoid treatmentNeonatal periodAdverse outcomesTotal incidencePrenatal treatmentRelative risk
1991
Hormonal Effects on the Surfactant Protein B (SP-B) mRNA in Cultured Fetal Rat Lung
Floros J, Gross I, Nichols K, Veletza S, Dynia D, Lu H, Wilson C, Peterec S. Hormonal Effects on the Surfactant Protein B (SP-B) mRNA in Cultured Fetal Rat Lung. American Journal Of Respiratory Cell And Molecular Biology 1991, 4: 449-454. PMID: 1850607, DOI: 10.1165/ajrcmb/4.5.449.Peer-Reviewed Original Research
1989
Survival of infants with persistent pulmonary hypertension without extracorporeal membrane oxygenation.
Dworetz A, Moya F, Sabo B, Gladstone I, Gross I. Survival of infants with persistent pulmonary hypertension without extracorporeal membrane oxygenation. Pediatrics 1989, 84: 1-6. PMID: 2740158, DOI: 10.1542/peds.84.1.1.Peer-Reviewed Original ResearchConceptsPersistent pulmonary hypertensionPulmonary hypertensionExtracorporeal membrane oxygenation therapyCorresponding survival figuresMembrane oxygenation therapyExtracorporeal membrane oxygenationRecords of infantsSurvival of infantsConservative therapyMembrane oxygenationOxygenation therapySurvival figuresRetrospective evaluationMortality rateHypertensionECMOTherapyPatientsInfantsConservative approachSurvivalEarly periodHyperventilationCriteriaMainstay
1988
Prevention of respiratory distress syndrome.
Moya F, Gross I. Prevention of respiratory distress syndrome. Seminars In Perinatology 1988, 12: 348-58. PMID: 3146813.Chapters
1986
Response of the Maternal, Fetal, and Neonatal Pituitary-Thyroid Axis to Thyrotropin-Releasing Hormone
Moya F, Mena P, Heusser F, Foradori A, Paiva E, Yazigi R, Michaud P, Gross I. Response of the Maternal, Fetal, and Neonatal Pituitary-Thyroid Axis to Thyrotropin-Releasing Hormone. Pediatric Research 1986, 20: 982-986. PMID: 3095783, DOI: 10.1203/00006450-198610000-00018.Peer-Reviewed Original ResearchConceptsFetal TSHMaternal administrationPostnatal increaseElective cesarean sectionThyrotropin-Releasing HormonePituitary-thyroid axesPituitary-thyroid axisMaternal T3Maternal TSHCesarean sectionPostnatal surgePregnant womenTRH administrationPrenatal exposureFetal pituitarySignificant elevationHigh doseT3 levelsHigh dosesTRHTSHPrior exposureAdministrationNeonatesSignificant increase
1985
Influence of Theophylline on Fetal Rat Lung Phosphatidylcholine Synthesis in vivo
Moya F, Gross I. Influence of Theophylline on Fetal Rat Lung Phosphatidylcholine Synthesis in vivo. Neonatology 1985, 8: 9-16. PMID: 3987490, DOI: 10.1159/000457017.Peer-Reviewed Original ResearchConceptsSerum levelsFetal lung surfactant productionInfluence of theophyllineLung tissue concentrationsElevated serum levelsDoses of theophyllineLung surfactant productionPhosphatidylcholine synthesisMaternal ratioPregnant ratsIntraperitoneal administrationTissue concentrationsRate of incorporationSurfactant productionTheophyllineVivoFetusesRatsAdministrationDosesDelayed Pulmonary Maturation in the Fetus of the Streptozotocin-Diabetic Rat
Gewolb I, Rooney S, Barrett C, Ingleson L, Light D, Wilson C, Smith G, Gross I, Warshaw J. Delayed Pulmonary Maturation in the Fetus of the Streptozotocin-Diabetic Rat. Experimental Lung Research 1985, 8: 141-151. PMID: 4029093, DOI: 10.3109/01902148509057518.Peer-Reviewed Original ResearchConceptsStreptozotocin-diabetic ratsDiabetic groupPulmonary maturationDay 21Lung developmentDelayed pulmonary maturationAlveolar lining cellsEffects of hyperglycemiaFetal lung developmentDays of gestationObserved developmental delayType II cellsControl lungsMaturational delayCholinephosphate cytidylyltransferase activityIntravenous injectionRat gestationDiabetic fetusesLining cellsDay 22Day 20FetusesActivity of enzymesDevelopmental delayDecreased number
1984
Corticosteroid binding by fetal rat and rabbit lung in organ culture
Ballard P, Ballard R, Gonzales L, Huemmelink R, Wilson C, Gross I. Corticosteroid binding by fetal rat and rabbit lung in organ culture. The Journal Of Steroid Biochemistry And Molecular Biology 1984, 21: 117-126. PMID: 6482426, DOI: 10.1016/0022-4731(84)90371-6.Peer-Reviewed Original ResearchConceptsRabbit lungsFetal ratsDexamethasone binding capacityConcentrations of dexamethasoneFetal lung cellsHalf-maximal stimulationGlucocorticoid effectsPhosphatidylcholine synthesisActive glucocorticoidsCorticosteroid metabolismDexamethasone bindingGlucocorticoid actionReceptor concentrationRabbit fetusesReceptor capacityFetal developmentRat lungLungBinding capacityFemale rabbitsLung cellsDexamethasoneCholine incorporationPhysiologic activityPrior exposure
1983
Lung surfactant in the hyperinsulinemic fetal monkey
Rooney S, Chu A, Gross I, Marino P, Schwartz R, Seghal P, Singer D, Susa J, Warshaw J, Wilson C. Lung surfactant in the hyperinsulinemic fetal monkey. Lung 1983, 161: 313-317. PMID: 6355669, DOI: 10.1007/bf02713877.Peer-Reviewed Original ResearchConceptsAbsence of hyperglycemiaBlood insulin levelsFetal rhesus monkeysEffect of hyperinsulinemiaInfusion of insulinSurfactant productionLung surfactant productionDiabetic mothersAlzet minipumpsInsulin levelsD gestationFetal monkeysFetal primateLung lavageLung tissueDays gestationLung slicesBody weightControl groupRhesus monkeysHyperinsulinemiaGestationCholine incorporationInhibitory effectHuman infantsCorticosteroid Stimulation of Phosphatidylcholine Synthesis in Cultured Fetal Rabbit Lung: Evidence for de Novo Protein Synthesis Mediated by Glucocorticoid Receptors*
GROSS I, BALLARD P, BALLARD R, JONES C, WILSON C. Corticosteroid Stimulation of Phosphatidylcholine Synthesis in Cultured Fetal Rabbit Lung: Evidence for de Novo Protein Synthesis Mediated by Glucocorticoid Receptors*. Endocrinology 1983, 112: 829-837. PMID: 6822213, DOI: 10.1210/endo-112-3-829.Peer-Reviewed Original Research
1979
Influence of Aminophylline and Cyclic AMP on Glycogen Metabolism in Fetal Rat Lung in Organ Culture
Maniscalco W, Wilson C, Gross I. Influence of Aminophylline and Cyclic AMP on Glycogen Metabolism in Fetal Rat Lung in Organ Culture. Pediatric Research 1979, 13: 1319-1322. PMID: 230447, DOI: 10.1203/00006450-197912000-00003.Peer-Reviewed Original ResearchConceptsFetal rat lungRat lungCyclic AMPFetal pulmonary surfactantInfluence of aminophyllineEffect of aminophyllineGlycogen synthase I activityOrgan cultureLung phospholipid synthesisGlycogen metabolismTotal phosphorylase activityDibutyryl cyclic AMPMonophosphate phosphodiesterase inhibitorSynthase I activityPhospholipid synthesisAminophyllinePhosphodiesterase inhibitorGlycogen contentLungGlycogen breakdownCyclic AMP treatmentAMP treatmentPulmonary surfactantAMPPhosphorylase activityThe influence of hormones on the biochemical development of fetal rat lung in organ culture I. Estrogen
Gross I, Wilson C, Ingleson L, Brehier A, Rooney S. The influence of hormones on the biochemical development of fetal rat lung in organ culture I. Estrogen. Biochimica Et Biophysica Acta 1979, 575: 375-383. PMID: 518894, DOI: 10.1016/0005-2760(79)90106-1.Peer-Reviewed Original ResearchConceptsFetal rat lungPercentage of radioactivityEstrogen actsFetal lungRat lungPhospholipid fractionInfluence of hormonesProtein/DNA ratioEstrogen treatmentIncorporation of cholineLungGlycogen contentTotal phospholipidsOrgan cultureSignificant stimulationPulmonary surfactantBiochemical developmentIndividual phospholipidsPhosphatidylcholine synthesisSignificant changesPhospholipid synthesisPhospholipidsAbundant phospholipidDNA ratioRadioactivityThe Hormonal Regulation of Fetal Lung Maturation
Gross I. The Hormonal Regulation of Fetal Lung Maturation. Clinics In Perinatology 1979, 6: 377-395. PMID: 230006, DOI: 10.1016/s0095-5108(18)31155-2.ChaptersThyrotropin-Releasing Hormone Increases the Amount of Surfactant in Lung Lavage from Fetal Rabbits
Rooney S, Marino P, Gobran L, Gross I, Warshaw J. Thyrotropin-Releasing Hormone Increases the Amount of Surfactant in Lung Lavage from Fetal Rabbits. Pediatric Research 1979, 13: 623-625. PMID: 112569, DOI: 10.1203/00006450-197905000-00009.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneLung lavageLung maturationFetal lung slicesRespiratory distress syndromeFetal lung maturationPulmonary surfactant productionSurfactant productionPhosphatidylcholine/sphingomyelin ratioDistress syndromeTRH administrationPregnant rabbitsIncorporation of cholineFetal rabbitsGestation resultsLung slicesLavagePhysiologic roleFetusesSphingomyelin ratioTotal phospholipidsControl littersSurfactant releasePhospholipid contentMore phosphatidylcholineEffects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung
Rooney S, Gobran L, Marino P, Maniscalco W, Gross I. Effects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung. Biochimica Et Biophysica Acta 1979, 572: 64-76. PMID: 216408, DOI: 10.1016/0005-2760(79)90200-5.Peer-Reviewed Original ResearchConceptsLung lavageFetal lung lavageFetal lung slicesAdministration of betamethasoneEffect of betamethasoneFetal lung maturationFetal rabbit lungPhosphatidylcholine/sphingomyelin ratioLung glycogenBetamethasone administrationLung maturationPregnant rabbitsDays gestationFetal lungLung slicesRabbit lungsStress-induced accelerationDirect administrationSphingomyelin ratioSurfactant phospholipidsBetamethasoneAdministrationRate of incorporationSurfactant productionLavage