2018
SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation
Yu X, Lao Y, Teng XL, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu LM, Cheng J, Li B, Su B, Jiang J, Li HB, Huang C, Yi J, Zou Q. SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nature Communications 2018, 9: 3157. PMID: 30089837, PMCID: PMC6082899, DOI: 10.1038/s41467-018-05676-6.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAnimalsAntineoplastic AgentsAutoimmunityBasic-Leucine Zipper Transcription FactorsBone Marrow CellsCD4-Positive T-LymphocytesCell DifferentiationCell Line, TumorCell NucleusCysteine EndopeptidasesFemaleGene DeletionGene Expression ProfilingGene Expression RegulationHEK293 CellsHomeostasisHumansImmune ToleranceLymphocyte ActivationMelanoma, ExperimentalMiceMice, Inbred C57BLMice, KnockoutPeptide HydrolasesReactive Oxygen SpeciesSumoylationT-Lymphocytes, RegulatoryConceptsRegulatory T cellsTreg cellsT cellsReactive oxygen speciesSUMO-specific protease 3T effector cell differentiationAntitumor T-cell responsesTreg cell-specific deletionT cell responsesEffector cell differentiationTreg cell stabilityCell-specific deletionT cell activationImmune toleranceTumor immunosuppressionAutoimmune symptomsImmune homeostasisRegulation of ROSRole of SENP3Cell activationCell responsesGene signatureProtease 3Pivotal regulatorNuclear export
2016
Chromosome Conformation Capture in Drosophila
Li HB. Chromosome Conformation Capture in Drosophila. Methods In Molecular Biology 2016, 1480: 207-212. PMID: 27659987, DOI: 10.1007/978-1-4939-6380-5_18.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell NucleusChromatinChromosomesDNADrosophilaMolecular BiologyNucleic Acid ConformationConceptsDNA-DNA interactionsChromosome conformation capture techniquesChromosome conformation captureInsulator proteinsConformation captureThree-dimensional structureChromatin fibersTemporal regulationRegulatory proteinsGene expressionDrosophilaChromatinProteinCapture techniquesImportant roleGenesPCGNucleusRegulationExpressionInteraction
2013
Insulators Target Active Genes to Transcription Factories and Polycomb-Repressed Genes to Polycomb Bodies
Li HB, Ohno K, Gui H, Pirrotta V. Insulators Target Active Genes to Transcription Factories and Polycomb-Repressed Genes to Polycomb Bodies. PLOS Genetics 2013, 9: e1003436. PMID: 23637616, PMCID: PMC3630138, DOI: 10.1371/journal.pgen.1003436.Peer-Reviewed Original ResearchConceptsPolycomb response elementsPolycomb target genesPolycomb bodiesTranscription factoriesTarget genesSpecialized transcription factoriesAbsence of CTCFInsulator protein CTCFInsulator proteinsPolycomb proteinsPolycomb groupProtein CTCFActive genesChromosomal contextCellular memoryEnhancer specificityGenomic clustersStable associationResponse elementGenesDifferent nuclear structuresTrithoraxCTCFActive stateCritical role
2011
A view of nuclear Polycomb bodies
Pirrotta V, Li HB. A view of nuclear Polycomb bodies. Current Opinion In Genetics & Development 2011, 22: 101-109. PMID: 22178420, PMCID: PMC3329586, DOI: 10.1016/j.gde.2011.11.004.Peer-Reviewed Original ResearchInsulators, Not Polycomb Response Elements, Are Required for Long-Range Interactions between Polycomb Targets in Drosophila melanogaster
Li HB, Müller M, Bahechar IA, Kyrchanova O, Ohno K, Georgiev P, Pirrotta V. Insulators, Not Polycomb Response Elements, Are Required for Long-Range Interactions between Polycomb Targets in Drosophila melanogaster. Molecular And Cellular Biology 2011, 31: 616-625. PMID: 21135119, PMCID: PMC3028641, DOI: 10.1128/mcb.00849-10.Peer-Reviewed Original ResearchConceptsPolycomb response elementsPcG targetsPcG complexesResponse elementChromosome conformation capture methodsPolycomb group complexesFab-7 elementHigher-order organizationPolycomb targetsDrosophila melanogasterEnhanced repressionInsulator activityRepressive activityTrans interactionsRegulatory elementsPhysical colocalizationFunctional assaysGroup complexesCapture methodComplexesFluorescence imagingPolycombDrosophilaMelanogasterMajor determinant