2024
The physiological and pathological roles of RNA modifications in T cells
Deng Y, Zhou J, Li H. The physiological and pathological roles of RNA modifications in T cells. Cell Chemical Biology 2024, 31: 1578-1592. PMID: 38986618, DOI: 10.1016/j.chembiol.2024.06.003.Peer-Reviewed Original ResearchRNA modificationsDynamic chemical modificationsInternal RNA modificationFunctions of mammalian cellsT cell developmentPathological roleRNA transcriptsCellular stimuliMammalian cellsRNA moleculesPost-transcriptionallyT cell biologyT cell survivalT cellsCell developmentCell survivalCell biologyRNAT cell-based immunotherapyCell-based immunotherapyT cell immunityAdaptive immunityCellsDifferentiationCell immunity
2021
m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity
Qin Y, Li B, Arumugam S, Lu Q, Mankash SM, Li J, Sun B, Li J, Flavell RA, Li HB, Ouyang X. m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity. Cell Reports 2021, 37: 109968. PMID: 34758326, PMCID: PMC8667589, DOI: 10.1016/j.celrep.2021.109968.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseProgression of NAFLDLineage-restricted deletionFatty liver diseaseMultiple mRNA transcriptsMyeloid cell activationDiet-induced developmentMethyladenosine (m<sup>6</sup>A) RNA modificationMRNA metabolismProtein methyltransferaseLiver diseaseRNA modificationsCellular stressMetabolic reprogrammingDDIT4 mRNACell activationObesityDifferential expressionMammalian targetMRNA transcriptsSignificant downregulationCytokine stimulationPathway activityMetabolic phenotypeMRNA levelsMultiple Functions of RNA Methylation in T Cells: A Review
Chao Y, Li H, Zhou J. Multiple Functions of RNA Methylation in T Cells: A Review. Frontiers In Immunology 2021, 12: 627455. PMID: 33912158, PMCID: PMC8071866, DOI: 10.3389/fimmu.2021.627455.Peer-Reviewed Original ResearchConceptsRNA methylationRNA modificationsMessenger RNAFate determinationEpigenetic regulationEpigenetic modificationsNoncoding RNAsCell homeostasisUbiquitous mechanismMethylationBiological significanceT cell homeostasisMultiple functionsCell proliferationEssential rolePotential therapeutic strategyRecent findingsRNAImmune responseBiological activityPathological statesT cellsCellsTherapeutic strategiesViral infection
2020
m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development
Gao Y, Vasic R, Song Y, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA, Li HB, Tebaldi T, Halene S. m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development. Immunity 2020, 52: 1007-1021.e8. PMID: 32497523, PMCID: PMC7408742, DOI: 10.1016/j.immuni.2020.05.003.Peer-Reviewed Original ResearchConceptsDouble-stranded RNADeleterious innate immune responseMammalian hematopoietic developmentEndogenous double-stranded RNAHematopoietic developmentInnate immune responseAbundant RNA modificationMurine fetal liverPattern recognition receptor pathwaysImmune responseProtein codingDsRNA formationRNA modificationsWriter METTL3Hematopoietic defectsPerinatal lethalityNative stateConditional deletionAberrant innate immune responsesLoss of METTL3Hematopoietic failureReceptor pathwayAberrant immune responsePrevents formationFetal liver
2018
RNA m6A modification and its function in diseases
Tong J, Flavell RA, Li HB. RNA m6A modification and its function in diseases. Frontiers Of Medicine 2018, 12: 481-489. PMID: 30097961, DOI: 10.1007/s11684-018-0654-8.Peer-Reviewed Original ResearchConceptsM6A modificationPost-transcriptional RNA modificationsRegulation of m6ACore catalytic componentFunction of m6ARNA m6A modificationRNA metabolismRegulatory networksRNA modificationsPhysiological contextHuman diseasesPhysiological roleM6ACatalytic componentFunctional relevanceCell linesM6A modulatorsDifferent cellsDisease conditionsTranscriptomeRecent advancesErasersRegulatorBindsModification
2016
Recent advances in dynamic m6A RNA modification
Cao G, Li HB, Yin Z, Flavell RA. Recent advances in dynamic m6A RNA modification. Open Biology 2016, 6: 160003. PMID: 27249342, PMCID: PMC4852458, DOI: 10.1098/rsob.160003.Peer-Reviewed Original ResearchConceptsRNA modificationsHigh-throughput sequencing analysisRNA epigenetic modificationM6A RNA modificationRNA splicingEpigenetic modificationsBiological functionsSequencing analysisTranscriptomeRecent advancesDynamic regulation processRegulation processesFundamental rolePossible roleDemethylasesRelated diseasesSplicingMammalsErasersImmune responseRegulationModificationRoleCytogeneticsTypical features