Privacy-Enhancing Technologies in Biomedical Data Science
Cho H, Froelicher D, Dokmai N, Nandi A, Sadhuka S, Hong M, Berger B. Privacy-Enhancing Technologies in Biomedical Data Science. Annual Review Of Biomedical Data Science 2024, 7: 317-343. PMID: 39178425, PMCID: PMC11346580, DOI: 10.1146/annurev-biodatasci-120423-120107.Peer-Reviewed Original ResearchConceptsPrivacy-enhancing technologiesAdoption of privacy-enhancing technologiesBiomedical data scienceData scienceAnalyze sensitive dataBiomedical data repositoriesPrivacy protectionSensitive dataPrivacy concernsData silosProtect privacyHuman subject dataBiomedical domainData repositoriesPrivacySubjective dataConventional frameworkSecure discovery of genetic relatives across large-scale and distributed genomic datasets
Hong M, Froelicher D, Magner R, Popic V, Berger B, Cho H. Secure discovery of genetic relatives across large-scale and distributed genomic datasets. Genome Research 2024, 34: gr.279057.124. PMID: 39111815, PMCID: PMC11529841, DOI: 10.1101/gr.279057.124.Peer-Reviewed Original ResearchMultiparty homomorphic encryptionIdentity-by-descentEffective hash functionsGenomic datasetsHomomorphic encryptionHash functionPrivate dataFederated algorithmBucketing strategyData holdersData silosDegree of relatednessRelation detectionGenetic relationEfficient algorithmMultiple entitiesRelatedness coefficientsPairs of individualsGenomic studiesDatasetIdentification of relationsRuntimeGenetic sequencesAccurate detectionAlgorithmSecure Discovery of Genetic Relatives Across Large-Scale and Distributed Genomic Datasets
Hong M, Froelicher D, Magner R, Popic V, Berger B, Cho H. Secure Discovery of Genetic Relatives Across Large-Scale and Distributed Genomic Datasets. Lecture Notes In Computer Science 2024, 14758: 308-313. PMID: 39027313, PMCID: PMC11257153, DOI: 10.1007/978-1-0716-3989-4_19.Peer-Reviewed Original ResearchIdentity-by-descentMultiparty homomorphic encryptionGenomic datasetsPairwise sequence comparisonsPrivacy-preserving solutionsDegree of relatednessEffective hash functionsGenetic relationPairs of individualsRelatedness coefficientsSequence comparisonCryptographic techniquesHomomorphic encryptionPrivacy guaranteesHash functionPrivate dataFederated algorithmPrivacy concernsGenetic sequencesData silosRelation detectionEfficient algorithmMultiple entitiesBurden of operatorsPrivacy