2024
Secure Discovery of Genetic Relatives Across Large-Scale and Distributed Genomic Datasets
Hong M, Froelicher D, Magner R, Popic V, Berger B, Cho H. Secure Discovery of Genetic Relatives Across Large-Scale and Distributed Genomic Datasets. Lecture Notes In Computer Science 2024, 14758: 308-313. PMID: 39027313, PMCID: PMC11257153, DOI: 10.1007/978-1-0716-3989-4_19.Peer-Reviewed Original ResearchIdentity-by-descentMultiparty homomorphic encryptionGenomic datasetsPairwise sequence comparisonsPrivacy-preserving solutionsDegree of relatednessEffective hash functionsGenetic relationPairs of individualsRelatedness coefficientsSequence comparisonCryptographic techniquesHomomorphic encryptionPrivacy guaranteesHash functionPrivate dataFederated algorithmPrivacy concernsGenetic sequencesData silosRelation detectionEfficient algorithmMultiple entitiesBurden of operatorsPrivacy
2023
sfkit: a web-based toolkit for secure and federated genomic analysis.
Mendelsohn S, Froelicher D, Loginov D, Bernick D, Berger B, Cho H. sfkit: a web-based toolkit for secure and federated genomic analysis. Nucleic Acids Research 2023, 51: w535-w541. PMID: 37246709, PMCID: PMC10320181, DOI: 10.1093/nar/gkad464.Peer-Reviewed Original ResearchConceptsCommand line interfaceGroup of collaboratorsCryptographic techniquesPrivacy concernsCollaborative workflowsUse casesWeb-based toolkitWeb serverComputational environmentCollaborative toolsMultiple partiesEssential taskDatasetServerPrivacyGenomic data collectionPrincipal component analysisToolkitData collectionWorkflowToolTaskComponent analysisRecent workComplexity
2018
Secure genome-wide association analysis using multiparty computation
Cho H, Wu D, Berger B. Secure genome-wide association analysis using multiparty computation. Nature Biotechnology 2018, 36: 547-551. PMID: 29734293, PMCID: PMC5990440, DOI: 10.1038/nbt.4108.Peer-Reviewed Original Research