2015
Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS
Wang Q, Yang C, Gelernter J, Zhao H. Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS. Human Genetics 2015, 134: 1195-1209. PMID: 26340901, PMCID: PMC4630076, DOI: 10.1007/s00439-015-1596-8.Peer-Reviewed Original ResearchMeSH KeywordsArthritis, RheumatoidCentral Nervous SystemCrohn DiseaseGenetic PleiotropyGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansImmune System DiseasesMental DisordersNerve Tissue ProteinsOrgan SpecificityPolymorphism, Single NucleotideQuantitative Trait LociSchizophreniaSystems IntegrationConceptsImmune disordersPsychiatric disordersCrohn's diseaseDisorder pairsMHC regionPervasive pleiotropyIntegrative analysisGenome-wide association studiesImmune dysregulationImmunological mechanismsTreatment strategiesTraits/diseasesEpidemiological observationsPsychiatric diseasesBrain disordersSame effect directionDiseaseDisordersGenomic regionsRealm of psychiatryMost allelesStrong pleiotropyAnnotation resourcesChromosome 6Association studies
2000
Assessing reliability of gene clusters from gene expression data
Zhang K, Zhao H. Assessing reliability of gene clusters from gene expression data. Functional & Integrative Genomics 2000, 1: 156-173. PMID: 11793234, DOI: 10.1007/s101420000019.Peer-Reviewed Original ResearchConceptsStatistical resampling methodsHierarchical clustering methodCluster identification methodNumerical algorithmGene expression dataClustering methodClustering treesResampling methodHierarchical clustering algorithmExpression dataExperiment designClustering algorithmAlgorithmChallenging problemData setsMeasured gene expression levelsEffect of variationData analysisClustersUncertaintyProblemReliability