2023
Profilin1 is required to prevent mitotic catastrophe in murine and human glomerular diseases
Tian X, Pedigo C, Li K, Ma X, Bunda P, Pell J, Lek A, Gu J, Zhang Y, Rangel P, Li W, Schwartze E, Nagata S, Lerner G, Perincheri S, Priyadarshini A, Zhao H, Lek M, Menon M, Fu R, Ishibe S. Profilin1 is required to prevent mitotic catastrophe in murine and human glomerular diseases. Journal Of Clinical Investigation 2023, 133: e171237. PMID: 37847555, PMCID: PMC10721156, DOI: 10.1172/jci171237.Peer-Reviewed Original ResearchConceptsProteinuric kidney diseaseKidney diseasePodocyte lossHuman glomerular diseasesMitotic catastrophePodocyte cell cycleSevere proteinuriaCell cycle reentryKidney failureGlomerular diseaseCell cycleKidney tissueG1/S checkpointUnsuccessful repairCyclin D1Glomerular integrityIrregular nucleiTissue-specific lossMouse podocytesPodocytesAltered expressionDiseaseCyclin B1Ribosome affinity purificationMultinucleated cells
2006
A Misclassification Model for Inferring Transcriptional Regulatory Networks
Vannucci M, Sun N, Zhao H. A Misclassification Model for Inferring Transcriptional Regulatory Networks. 2006, 347-365. DOI: 10.1017/cbo9780511584589.019.Peer-Reviewed Original ResearchTranscriptional regulatory networksGene expression dataRegulatory networksExpression dataUnderlying transcriptional regulatory networksProtein-DNA binding dataNetwork reconstructionSet of proteinsYeast cell cycleMutual regulatory interactionsRegulatory network reconstructionGene regulationRegulatory interactionsSpecific genesCell cycleGenesBiological researchExpression levelsProteinTRNBinding dataHigh connectivityTransient stimulationRecent advancesStatistical framework