2021
Early Functional and Cognitive Declines Measured by Auditory-Evoked Cortical Potentials in Mice With Alzheimer’s Disease
Mei L, Liu L, Chen K, Zhao H. Early Functional and Cognitive Declines Measured by Auditory-Evoked Cortical Potentials in Mice With Alzheimer’s Disease. Frontiers In Aging Neuroscience 2021, 13: 710317. PMID: 34588972, PMCID: PMC8473830, DOI: 10.3389/fnagi.2021.710317.Peer-Reviewed Original ResearchAuditory cortexCognitive declineEvent-related potentialsCortical potentialsCognitive activityCognitive changesNeural activationAD-related dementiaAD micePeak N2APP/PS1 AD miceAmyloid precursor proteinAlzheimer's diseasePeak P3AuditoryAuditory brainstem response recordingsNormal aging effectP1 peakCBA/CaJ micePeak P1Subdermal needle electrodesObjective biomarkersP3AECPCBA mice
2019
Hearing loss is an early biomarker in APP/PS1 Alzheimer’s disease mice
Liu Y, Fang S, Liu L, Zhu Y, Li C, Chen K, Zhao H. Hearing loss is an early biomarker in APP/PS1 Alzheimer’s disease mice. Neuroscience Letters 2019, 717: 134705. PMID: 31870800, PMCID: PMC7004828, DOI: 10.1016/j.neulet.2019.134705.Peer-Reviewed Original ResearchConceptsAPP/PS1 AD miceDistortion product otoacoustic emissionsAuditory brainstem responseAD miceHearing lossAlzheimer's diseaseDisease miceAPP/PS1 Alzheimer's disease miceAPP/PS1 miceAD mouse modelAlzheimer's disease miceMedial geniculate bodyWild-type littermatesCochlear microphonic recordingsProduct otoacoustic emissionsMonths of ageSpatial learning deficitsPS1 miceUpper brainstemABR thresholdFunction testingGeniculate bodyBrainstem responseLateral lemniscusEarly biomarkers