2024
Mapping the structure-function relationship along macroscale gradients in the human brain
Collins E, Chishti O, Obaid S, McGrath H, King A, Shen X, Arora J, Papademetris X, Constable R, Spencer D, Zaveri H. Mapping the structure-function relationship along macroscale gradients in the human brain. Nature Communications 2024, 15: 7063. PMID: 39152127, PMCID: PMC11329792, DOI: 10.1038/s41467-024-51395-6.Peer-Reviewed Original ResearchConceptsStructure-function correspondenceBrain regionsMacroscale gradientWhite matter connectivityHuman brain regionsStructure-function couplingNeural network propertiesAssociation cortexCognitive functionBridging neuroscienceFunctional coactivationOrganizational axisCortical thicknessHuman brainMotor cortexLanguage processingBrainCortexMotor functionNatural language processingNetwork propertiesMotorNeuroscienceNatural languageData repositories
2023
Outcomes in Patients With Poststroke Seizures
Misra S, Kasner S, Dawson J, Tanaka T, Zhao Y, Zaveri H, Eldem E, Vazquez J, Silva L, Mohidat S, Hickman L, Khan E, Funaro M, Nicolo J, Mazumder R, Yasuda C, Sunnerhagen K, Ihara M, Ross J, Liebeskind D, Kwan P, Quinn T, Engel J, Mishra N. Outcomes in Patients With Poststroke Seizures. JAMA Neurology 2023, 80: 1155-1165. PMID: 37721736, PMCID: PMC10507596, DOI: 10.1001/jamaneurol.2023.3240.Peer-Reviewed Original ResearchConceptsPoststroke seizuresPoor functional outcomeLate seizuresEarly seizuresStroke subtypesFunctional outcomeOdds ratioSystematic reviewJoanna Briggs Institute toolsHemorrhagic stroke subtypesOutcomes of patientsHistory of strokeTrials of interventionsRisk of biasMeta-Analyses (PRISMA) checklistPreferred Reporting ItemsMeta-regression analysisWeb of ScienceRecurrent strokeGreater disabilityPoor outcomeDementia riskSubgroup analysisBias assessmentEgger's testQuantitative assessment of burst suppression as a predictor of seizure recurrence in refractory status epilepticus
Fong M, Pu K, Jadav R, Khan T, Hirsch L, Zaveri H. Quantitative assessment of burst suppression as a predictor of seizure recurrence in refractory status epilepticus. Clinical Neurophysiology 2023, 150: 98-105. PMID: 37060844, PMCID: PMC11265649, DOI: 10.1016/j.clinph.2023.03.011.Peer-Reviewed Original ResearchSeizure forecasting: Where do we stand?
Andrzejak R, Zaveri H, Schulze‐Bonhage A, Leguia M, Stacey W, Richardson M, Kuhlmann L, Lehnertz K. Seizure forecasting: Where do we stand? Epilepsia 2023, 64: s62-s71. PMID: 36780237, PMCID: PMC10423299, DOI: 10.1111/epi.17546.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2022
High-resolution cortical parcellation based on conserved brain landmarks for localization of multimodal data to the nearest centimeter
McGrath H, Zaveri H, Collins E, Jafar T, Chishti O, Obaid S, Ksendzovsky A, Wu K, Papademetris X, Spencer D. High-resolution cortical parcellation based on conserved brain landmarks for localization of multimodal data to the nearest centimeter. Scientific Reports 2022, 12: 18778. PMID: 36335146, PMCID: PMC9637135, DOI: 10.1038/s41598-022-21543-3.Peer-Reviewed Original ResearchConceptsEpilepsy surgery cohortStandardized brain regionsBrain structure-function relationshipsSurgery cohortClinical usefulnessBrain metricsAnatomical locationBrain regionsBrain localizationCortical parcellationOwn unique benefitsIntracranial electroencephalographyAnatomical designationBrain anatomyHuman brain anatomyHuman brainBrain atlasBrain landmarksBrain atlasesParcellationMagnetic resonanceNearest centimeterAnatomical featuresAnatomyCortical localization
2021
International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke
Mishra NK, Engel J, Liebeskind DS, Sharma VK, Hirsch LJ, Kasner SE, French JA, Devinsky O, Friedman A, Dawson J, Quinn TJ, Selim M, de Havenon A, Yasuda CL, Cendes F, Benninger F, Zaveri HP, Burneo JG, Srivastava P, Singh M, Bhatia R, Vishnu VY, Bentes C, Ferro J, Weiss S, Sivaraju A, Kim JA, Galovic M, Gilmore EJ, Pitkänen A, Davis K, Sansing LH, Sheth KN, Paz JT, Singh A, Sheth S, Worrall BB, Grotta JC, Casillas-Espinos PM, Chen Z, Nicolo JP, Yan B, Kwan P, Consortium F. International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke. Epilepsy & Behavior 2021, 127: 108502. PMID: 34968775, DOI: 10.1016/j.yebeh.2021.108502.Peer-Reviewed Original ResearchPassive Localization of the Central Sulcus during Sleep Based on Intracranial EEG
Alkawadri R, Zaveri HP, Sheth KN, Spencer DD. Passive Localization of the Central Sulcus during Sleep Based on Intracranial EEG. Cerebral Cortex 2021, 32: 3726-3735. PMID: 34921723, PMCID: PMC9764437, DOI: 10.1093/cercor/bhab443.Peer-Reviewed Original ResearchConceptsCentral sulcusMotor cortexMotor areaLeg motor areaPrimary motor cortexIntracranial EEG monitoringTongue motor areaLocal network activityMotor/premotorSM cortexIntractable epilepsySensorimotor cortexAnterior bankNREM sleepSensory cortexEEG monitoringZ-scoreHigher EEGCortexIntracranial EEGSignificant differencesPatientsSleepNetwork activityPrimary handCombining Transcranial Doppler and EEG Data to Predict Delayed Cerebral Ischemia After Subarachnoid Hemorrhage
Chen HY, Elmer J, Zafar SF, Ghanta M, Moura Junior V, Rosenthal ES, Gilmore EJ, Hirsch LJ, Zaveri HP, Sheth KN, Petersen NH, Westover MB, Kim JA. Combining Transcranial Doppler and EEG Data to Predict Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. Neurology 2021, 98: e459-e469. PMID: 34845057, PMCID: PMC8826465, DOI: 10.1212/wnl.0000000000013126.Peer-Reviewed Original ResearchSmall loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity
Farina MG, Sandhu MRS, Parent M, Sanganahalli BG, Derbin M, Dhaher R, Wang H, Zaveri HP, Zhou Y, Danbolt NC, Hyder F, Eid T. Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity. Epilepsia 2021, 62: 2858-2870. PMID: 34536233, PMCID: PMC9006438, DOI: 10.1111/epi.17072.Peer-Reviewed Original ResearchConceptsPostnatal brainFunctional connectivityContinuous video-electroencephalographic recordingSpontaneous recurrent seizuresPathogenesis of epilepsyGlutamine synthetase deficiencyVideo-electroencephalographic recordingsSpecific animal modelsEx vivo studySeizure thresholdAdult patientsRecurrent seizuresFocal epilepsyAdeno-associated virusHippocampal formationAnimal modelsFocal mannerEpileptic seizuresGS deficiencySmall lociSynthetase deficiencyEpilepsyGradual returnVivo studiesBrainIncreased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain
Ong C, Damisah EC, Gruenbaum SE, Dhaher R, Deng Y, Sandhu MRS, Zaveri HP, Spencer DD, Eid T. Increased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain. Epilepsia 2021, 62: e88-e97. PMID: 33949690, PMCID: PMC11259155, DOI: 10.1111/epi.16920.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmino Acids, Branched-ChainBrain ChemistryChildChild, PreschoolChromatography, High Pressure LiquidDrug Resistant EpilepsyElectrocorticographyElectroencephalographyEpilepsies, PartialExtracellular SpaceFemaleGlutamic AcidHumansIsoleucineMaleMicrodialysisMiddle AgedSeizuresTandem Mass SpectrometryYoung AdultConceptsSpontaneous seizuresDrug-resistant focal epilepsyExtracellular brain glutamateHuman epileptic brainBranched-chain amino acidsBranched chain amino acids valineRefractory epilepsyBrain microdialysisGlutamatergic neurotransmissionFocal epilepsySeizure onsetBrain glutamateEpileptic brainHuman patientsSeizuresBrain regionsDialysis samplesMammalian targetEpilepsyLiquid chromatography-tandem mass spectrometryBaselineBCAAIntracranial electroencephalographyChromatography-tandem mass spectrometryPatientsGraph‐based risk assessment and error detection in radiation therapy
Munbodh R, Bowles JK, Zaveri HP. Graph‐based risk assessment and error detection in radiation therapy. Medical Physics 2021, 48: 965-977. PMID: 33340128, DOI: 10.1002/mp.14666.Peer-Reviewed Original ResearchConceptsGraph traversalConstraint satisfaction problemsSoftware entitiesConstraint programmingDetection of errorsActivity diagramsHardware systemSatisfaction problemsLogical formulasError detectionTractable unitsQuality assuranceConstraint violationsModular approachGraph theoryPlanning systemGraphTraversalModuleQA processVerify systemForms of inconsistencyLogical inconsistenciesAnatomical contoursAssurance
2020
Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions
Percy J, Zaveri H, Duckrow RB, Gerrard J, Farooque P, Hirsch LJ, Spencer DD, Sivaraju A. Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions. Epilepsy & Behavior 2020, 111: 107231. PMID: 32615416, DOI: 10.1016/j.yebeh.2020.107231.Peer-Reviewed Original ResearchConceptsLong-term seizure freedomSeizure freedomSeizure frequencyElectrode implantationIntracranial studiesLong-term seizure reductionAdditional surgical interventionSeizure onset localizationIntracranial electroencephalogram monitoringSeizure reductionConsecutive patientsSurgical interventionEpileptogenic networksElectroencephalogram monitoringNeuromodulatory effectsRetrospective analysisIntracranial monitoringTransient improvementDepth electrodesPatientsYear 4ImplantationAdequate dataYearsControversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference
Zaveri HP, Schelter B, Schevon CA, Jiruska P, Jefferys JGR, Worrell G, Schulze-Bonhage A, Joshi RB, Jirsa V, Goodfellow M, Meisel C, Lehnertz K. Controversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference. Seizure 2020, 78: 78-85. PMID: 32272333, PMCID: PMC7952007, DOI: 10.1016/j.seizure.2020.03.010.Peer-Reviewed Original Research
2019
Slowing less than 1 Hz is decreased near the seizure onset zone
Lundstrom BN, Boly M, Duckrow R, Zaveri HP, Blumenfeld H. Slowing less than 1 Hz is decreased near the seizure onset zone. Scientific Reports 2019, 9: 6218. PMID: 30996228, PMCID: PMC6470162, DOI: 10.1038/s41598-019-42347-y.Peer-Reviewed Original ResearchConceptsSeizure onset zoneOnset zoneFocal slowingFocal cerebral dysfunctionLocation of dysfunctionFocal epilepsy patientsSlow wave activitySlow oscillationsLocal synaptic strengthsSlow oscillation activityCerebral dysfunctionReduced inhibitory activityPostictal statePostictal slowingEpilepsy patientsModulatory effectsSynaptic strengthDelta frequencyCortical mechanismsIntracranial recordingsDistinct neural mechanismsIntracranial electroencephalographyNeural mechanismsDysfunctionSleep
2018
Resting state connectivity in neocortical epilepsy: The epilepsy network as a patient-specific biomarker
Marino AC, Yang GJ, Tyrtova E, Wu K, Zaveri HP, Farooque P, Spencer DD, Bandt SK. Resting state connectivity in neocortical epilepsy: The epilepsy network as a patient-specific biomarker. Clinical Neurophysiology 2018, 130: 280-288. PMID: 30605890, DOI: 10.1016/j.clinph.2018.11.016.Peer-Reviewed Original ResearchConceptsLocalization related epilepsyEpilepsy networkSeizure onset locationSingle-patient levelCorrelated network activityPatient-specific biomarkersRelated epilepsyConnectivity patternsNeocortical epilepsyPatient levelSeizure onsetInterictal periodAnatomic locationPatientsPossible biomarkersState connectivityCortical regionsSingle-subject levelTopographic distributionCohortNetwork disorderBrain networksEpilepsyNetwork activityBiomarkersA Review of Cerebral Shunts, Current Technologies, and Future Endeavors.
Soler GJ, Bao M, Jaiswal D, Zaveri HP, DiLuna ML, Grant RA, Hoshino K. A Review of Cerebral Shunts, Current Technologies, and Future Endeavors. The Yale Journal Of Biology And Medicine 2018, 91: 313-321. PMID: 30258318, PMCID: PMC6153620.Peer-Reviewed Original ResearchSeizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogram
Joshi RB, Duckrow RB, Goncharova II, Gerrard JL, Spencer DD, Hirsch LJ, Godwin DW, Zaveri HP. Seizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogram. Epilepsia 2018, 59: 2075-2085. PMID: 30187919, DOI: 10.1111/epi.14559.Peer-Reviewed Original ResearchConceptsAED taperYale-New Haven HospitalAdult epilepsy patientsSeizure forecasting algorithmsElectrode contact pairsSeizure onset areaSeizure susceptibilityClinical recordsDrug taperElectrophysiological changesEpilepsy patientsIntracranial electroencephalographic dataMagnitude-squared coherenceModulatory activitySeizuresPatientsOnset areaPreseizurePostseizureProgressive desynchronizationIntracranial electroencephalogramDaysIctogenesisEffect of timeHospitalSeizure prediction — ready for a new era
Kuhlmann L, Lehnertz K, Richardson MP, Schelter B, Zaveri HP. Seizure prediction — ready for a new era. Nature Reviews Neurology 2018, 14: 618-630. PMID: 30131521, DOI: 10.1038/s41582-018-0055-2.Peer-Reviewed Original ResearchConceptsUnpredictability of seizuresAstrocytes and Glutamine Synthetase in Epileptogenesis
Eid T, Lee T, Patrylo P, Zaveri HP. Astrocytes and Glutamine Synthetase in Epileptogenesis. Journal Of Neuroscience Research 2018, 97: 1345-1362. PMID: 30022509, PMCID: PMC6338538, DOI: 10.1002/jnr.24267.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyLobe epilepsyAstrocytic glutamine synthetaseRole of astrocytesPotassium channel Kir4.1Important causative factorExcitatory amino acid transporters EAAT1Antiepileptogenic interventionsEpileptogenic insultAntiepileptogenic therapiesEpilepsy developmentChannel Kir4.1Aquaporin-4EpilepsyCausative factorsTransporters EAAT1New targetsSuch interventionsTransporters MCT1DysfunctionAstrocytesMetabolic mechanismsGlutamine synthetaseDownstream effectsThe roles of surgery and technology in understanding focal epilepsy and its comorbidities
Spencer DD, Gerrard JL, Zaveri HP. The roles of surgery and technology in understanding focal epilepsy and its comorbidities. The Lancet Neurology 2018, 17: 373-382. PMID: 29553383, DOI: 10.1016/s1474-4422(18)30031-0.Peer-Reviewed Original ResearchConceptsFocal epilepsyNeuropsychiatric disordersComplete seizure controlPoor postsurgical outcomeRole of surgeryRefractory focal epilepsyOnset areaComorbid neuropsychiatric disordersSeizure onset areaBehavioral seizuresSeizure controlSurgical outcomesPostsurgical outcomesEpileptogenic tissueEpilepsy networkHigh prevalenceStructural brain networksIndividualised therapyPatientsBrain regionsEpilepsyElectrophysiological recordingsIntracranial electrophysiological recordingsStructural MRIGold standard