2024
Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults
Colic L, Sankar A, Goldman D, Kim J, Blumberg H. Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults. Molecular Psychiatry 2024, 1-13. PMID: 39333385, DOI: 10.1038/s41380-024-02758-4.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingVentral prefrontal cortexBipolar disorderPrefrontal cortexNeurodevelopmental modelBrain systemsMood statesFunctional magnetic resonance imaging studyModel of bipolar disorderProcessing of rewardAcute mood statesRegulation of emotionVentral cortical regionsYoung adultsFunctional imaging findingsTrait vulnerabilityMood episodesSyndromal BDNeuroimaging evidenceFunctional neuroanatomyBrain differencesNeuroimaging studiesNeurodevelopmental mechanismsPrecentral gyrusBrain regions
2022
Rethinking “aggression” and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features
Drachman R, Colic L, Sankar A, Spencer L, Goldman DA, Villa LM, Kim JA, Oquendo MA, Pittman B, Blumberg HP. Rethinking “aggression” and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features. Journal Of Affective Disorders 2022, 303: 331-339. PMID: 35181384, PMCID: PMC9109470, DOI: 10.1016/j.jad.2022.02.047.Peer-Reviewed Original ResearchConceptsSubstance use disordersChildhood Trauma QuestionnaireChildhood maltreatmentBarratt Impulsiveness Scale scoresBipolar disorderAnterior cingulate cortexEmotional childhood maltreatmentElevated mood statesBIS total scoreBilateral orbitofrontal cortexMotor impulsivenessSuicide attemptsOrbitofrontal cortexImpulsiveness scoresMood statesBehavioral dyscontrolCingulate cortexBehavioral constructsTrauma QuestionnaireBrain circuitrySocial behaviorElevated aggressionModest sample sizeBrain regionsSuicide ideation
2021
A graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder
Goldman DA, Sankar A, Colic L, Villa L, Kim JA, Pittman B, Constable RT, Scheinost D, Blumberg HP. A graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder. Bipolar Disorders 2021, 24: 412-423. PMID: 34665907, PMCID: PMC9016085, DOI: 10.1111/bdi.13144.Peer-Reviewed Original ResearchConceptsLenticular nucleusFunctional connectivityPrefrontal cortexMood statesYoung adultsLimited brain regionsAcute mood statesRight lenticular nucleusBipolar I disorderDorsal prefrontal cortexPrevious neuroimaging studiesWhole-brain approachTemporal functional connectivityFunctional magnetic resonanceLeft prefrontal cortexBrain dysfunctionContralateral homologuesHealthy controlsI disordersDepression scoresICD increasesRight cerebellumBipolar disorderEarly interventionBrain regions
2020
Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder
Sankar A, Purves K, Colic L, Lippard ETC, Millard H, Fan S, Spencer L, Wang F, Pittman B, Constable RT, Gross JJ, Blumberg HP. Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder. Bipolar Disorders 2020, 23: 152-164. PMID: 32521570, PMCID: PMC7790437, DOI: 10.1111/bdi.12954.Peer-Reviewed Original ResearchConceptsExplicit emotion regulationEmotion regulationBrain responsesMood statesDorsal anterior cingulate cortexEmotion regulation difficultiesHappy facial stimuliFrontal cortex functioningDorsal frontal regionsBipolar disorderAcute mood symptomsAnterior cingulate cortexFunctional MRI dataMajor suicide risk factorsNegative affective symptomsEuthymic mood stateRegional brain responsesFacial stimuliRegulation difficultiesFrontal engagementMOFC responseNegative emotionsLoss of motivationDiminished motivationEuthymic individuals
2003
A Functional Magnetic Resonance Imaging Study of Bipolar Disorder: State- and Trait-Related Dysfunction in Ventral Prefrontal Cortices
Blumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, Charney DS, Gore JC, Krystal JH, Peterson BS. A Functional Magnetic Resonance Imaging Study of Bipolar Disorder: State- and Trait-Related Dysfunction in Ventral Prefrontal Cortices. JAMA Psychiatry 2003, 60: 601-609. PMID: 12796223, DOI: 10.1001/archpsyc.60.6.601.Peer-Reviewed Original ResearchConceptsVentral prefrontal cortexBipolar disorderPrefrontal cortexMood statesMagnetic resonance imaging studyHealthy control subjectsAcute mood statesLeft ventral prefrontal cortexResonance imaging studySignal changesDisturbances of attentionFunctional magnetic resonance imaging studyAnterior cingulate cortexBipolar disorder IDorsal anterior cingulateEvent-related functional magnetic resonanceFunctional magnetic resonanceAcute episodeControl subjectsExaggerated increaseFunctional impairmentBlunted activationMood episodesSpecific mood statesPrefrontal abnormalities