Featured Publications
Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape
Baranowski C, Welsh M, Sham L, Eskandarian H, Lim H, Kieser K, Wagner J, McKinney J, Fantner G, Ioerger T, Walker S, Bernhardt T, Rubin E, Rego E. Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape. ELife 2018, 7: e37516. PMID: 30324906, PMCID: PMC6231781, DOI: 10.7554/elife.37516.Peer-Reviewed Original ResearchConceptsPenicillin-binding proteinsAsymmetric polar growthRod-shaped bacteriaPolar growthPolar elongationShape maintenanceCell wallGenetic relationshipsDrug targetsUnusual crosslinksD-transpeptidasesSingle cellsPeptidoglycanCellsCrosslinksProteinMycobacteriaBacteriaPathogensTypes of crosslinksElongationGrowthMaintenanceTarget
2018
Characterization of Conserved and Novel Septal Factors in Mycobacterium smegmatis
Wu K, Zhang J, Baranowski C, Leung V, Rego E, Morita Y, Rubin E, Boutte C. Characterization of Conserved and Novel Septal Factors in Mycobacterium smegmatis. Journal Of Bacteriology 2018, 200: 10.1128/jb.00649-17. PMID: 29311277, PMCID: PMC5826036, DOI: 10.1128/jb.00649-17.Peer-Reviewed Original ResearchConceptsCell wallModel organismsCell wall regulationIntracellular membrane domainCell wall biosynthesisCell wall precursorsCell wall structureCritical regulatory functionsBacterial cell wallDifferent regulatory mechanismsWall biosynthesisDistant speciesMembrane domainsCoordinated regulationElongation functionStructural homologsWall precursorsDivision processRegulatory mechanismsHomologMycobacterial cell wallRegulatory functionsCell survivalDifferent regulatorsCell growth