2023
Age-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing
Chaudhary S, Zhang S, Zhornitsky S, Chen Y, Chao H, Li C. Age-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing. NeuroImage 2023, 276: 120207. PMID: 37263454, PMCID: PMC10330646, DOI: 10.1016/j.neuroimage.2023.120207.Peer-Reviewed Original ResearchConceptsFaster reaction timesNegative emotionsAge-related declineEmotional stimuliTrait anxietyAge-related reductionReaction timeEmotion regulation literatureSalient emotional stimuliPositive emotional stimuliFacial emotion processingPrefrontal cortical responsesRostral anterior cingulate cortexWhole-brain regressionAnterior cingulate activityDefault mode networkAnterior cingulate cortexEmotion regulationNeural evidenceEmotion processingDorsolateral PFCStimulus registrationDiminished anxietyPsychophysiological interactionEmotional circuitsDoes ADT Influence the Risk of Suicidal Ideation among US Veteran Prostate Cancer Patients Pre-Exposed to PTSD?
Brahmbhatt S, Chao H, Verma S, Gupta S. Does ADT Influence the Risk of Suicidal Ideation among US Veteran Prostate Cancer Patients Pre-Exposed to PTSD? Cancers 2023, 15: 2739. PMID: 37345076, PMCID: PMC10216772, DOI: 10.3390/cancers15102739.Peer-Reviewed Original ResearchThe effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates
Chaudhary S, Chen Y, Zhornitsky S, Le T, Zhang S, Chao H, Dominguez J, Li C. The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates. Addiction Biology 2023, 28: e13278. PMID: 37252876, DOI: 10.1111/adb.13278.Peer-Reviewed Original ResearchConceptsPositive alcohol expectanciesAlcohol Use Disorders Identification TestAlcohol expectanciesAlcohol use disorderNeural correlatesCue responsesPath analysisProblem drinkingAlcohol misuseEffect of ageAUDIT scoresRostral anterior cingulate cortexWhole-brain regressionAlcohol cue exposureMiddle occipital cortexModerate alcohol use disorderAlcohol Expectancy QuestionnaireAnterior cingulate cortexAlcohol use severityBilateral rostral anterior cingulate cortexPsychological mechanismsBilateral parahippocampal gyrusCue exposureNeural processesSeverity of problems
2022
Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls
Chaudhary S, Zhornitsky S, Chao H, van Dyck C, Li C. Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls. Journal Of Alzheimer's Disease 2022, 90: 1615-1628. PMID: 36314209, PMCID: PMC10064487, DOI: 10.3233/jad-220708.Peer-Reviewed Original ResearchConceptsMiddle temporal gyrusMild cognitive impairmentMotivation circuitsFunctional connectivityPath analysisWhole-brain regressionPCu/PCCState functional connectivityTotal scoreTemporal gyrusNeural markersCingulate cortexMemory dysfunctionRSFCHealthy controlsCognitive statusCognitive impairmentAlzheimer's diseaseApathyPrecuneusMemoryRsFCsDepressionScale total scoreCognitive subscores
2021
Improving hematology/oncology clinical research recruitment via universal prescreening: The VA Connecticut (VACT) Cancer Center experience.
Xiang J, Roy A, Summers C, Delvy M, O'Donovan J, Christensen J, Perry L, Connery D, Rose M, Chao H. Improving hematology/oncology clinical research recruitment via universal prescreening: The VA Connecticut (VACT) Cancer Center experience. Journal Of Clinical Oncology 2021, 39: 79-79. DOI: 10.1200/jco.2020.39.28_suppl.79.Peer-Reviewed Original ResearchLung cancer patientsCancer CenterClinical research recruitmentStudy enrollmentCancer patientsClinical trialsPotential eligibilityEligibility criteriaNew lung cancer patientsResearch enrollmentPotential study patientsCancer Center experienceTherapeutic clinical trialsNumber of patientsDiagnosis of cancerResearch recruitmentEligible patientsMalignancy workupPrimary oncologistStudy patientsChart reviewClinic visitsGenitourinary cancersPatient demographicsCenter experience
2018
Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers
Zhornitsky S, Ide J, Wang W, Chao H, Zhang S, Hu S, Krystal J, Li C. Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers. Brain Connectivity 2018, 8: 487-502. PMID: 30198312, PMCID: PMC6207153, DOI: 10.1089/brain.2018.0633.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestResting-state functional connectivityThalamic connectivityCaudate connectivityFrontal associationThalamic dysfunctionCaudate headProblem drinkingWhole-brain linear regressionAE scoreSubcortical structuresFunctional connectivityBilateral caudate headRight caudate headDisorders Identification TestSex differencesThalamic subdivisionsThalamic subregionsParietal associationAlcohol misuseThalamusWhite matter tractographyAUDIT scoresNondependent drinkersAlcohol expectancies
2017
Concurrent Care and Aggressive End-of-Life Lung Cancer Care
Presley C, Han L, O'leary J, Chao H, Shamas T, Kerin A, Rose M, Gross C. Concurrent Care and Aggressive End-of-Life Lung Cancer Care. Journal Of Thoracic Oncology 2017, 12: s1545. DOI: 10.1016/j.jtho.2017.06.058.Peer-Reviewed Original Research
2013
Changes in cerebral morphometry and amplitude of low-frequency fluctuations of BOLD signals during healthy aging: correlation with inhibitory control
Hu S, Chao H, Zhang S, Ide JS, Li CS. Changes in cerebral morphometry and amplitude of low-frequency fluctuations of BOLD signals during healthy aging: correlation with inhibitory control. Brain Structure And Function 2013, 219: 983-994. PMID: 23553547, PMCID: PMC3760988, DOI: 10.1007/s00429-013-0548-0.Peer-Reviewed Original ResearchConceptsDorsal lateral prefrontal cortexInferior parietal lobuleSupplementary motor areaFrontal regionsInhibitory controlCingulate cortexStop-signal reaction timeBilateral dorsal lateral prefrontal cortexGM volumeCognitive performance decreasesRight inferior parietal lobuleLow-frequency fluctuationsLateral prefrontal cortexSignal reaction timePosterior cingulate cortexAnterior cingulate cortexBlood oxygenation level-dependent (BOLD) signalLevel-dependent signalFamily-wise errorGray matter volumeRecent alcohol useCognitive challengesParietal lobuleSpontaneous neural activityVoxel-based morphometry
2012
Timeliness of care and stage at diagnosis of non-small cell lung cancer (NSCLC) with the implementation of a cancer care coordination program (CCCP) at a VA medical center.
Alsamarai S, Chao H, Yao X, Deng Y, Rose M. Timeliness of care and stage at diagnosis of non-small cell lung cancer (NSCLC) with the implementation of a cancer care coordination program (CCCP) at a VA medical center. Journal Of Clinical Oncology 2012, 30: 6033-6033. DOI: 10.1200/jco.2012.30.15_suppl.6033.Peer-Reviewed Original ResearchNon-small cell lung cancerTimeliness of careLung cancerEarly-stage lung cancerVeterans Affairs Connecticut Healthcare SystemPercent of patientsInitiation of therapyRetrospective cohort analysisCare coordination programCancer-related symptomsInitiation of treatmentCell lung cancerPrimary care providersStage lung cancerVA Medical CenterAbnormal imagingNSCLC careNSCLC patientsInitial imagingPatient satisfactionMean intervalMedical CenterCohort analysisAbnormal imagesCare providersThe effects of age on cerebral activations: internally versus externally driven processes
Hu S, Chao H, Winkler AD, Li CS. The effects of age on cerebral activations: internally versus externally driven processes. Frontiers In Aging Neuroscience 2012, 4: 4. PMID: 22536185, PMCID: PMC3334814, DOI: 10.3389/fnagi.2012.00004.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingCerebral activationRegional brain activationAge-related decreaseCognitive processesPrepotent responsesPsychological constructsCognitive functioningSignal taskBrain activationGo trialsFMRI dataGo signalSE trialsEffect of ageImaging literatureYoung adultsStop signalHealthy adultsInfluence of ageSeeming inconsistencyAdultsMagnetic resonance imagingYears of ageFunctioning
2010
The prevention of chemotherapy induced peripheral neuropathy by concurrent treatment with drugs used for bipolar disease: a retrospective chart analysis in human cancer patients
Wadia R, Stolar M, Grens C, Ehrlich B, Chao H. The prevention of chemotherapy induced peripheral neuropathy by concurrent treatment with drugs used for bipolar disease: a retrospective chart analysis in human cancer patients. Oncotarget 2010, 5: 2-2. DOI: 10.18632/oncotarget.23441.Peer-Reviewed Original ResearchPeripheral neuropathyNeuronal calcium sensor-1Valproic acidSide effectsBipolar diseaseRetrospective chart review studyDose-limiting side effectChemotherapeutic drugsAltered calcium signalingDevelopment of CIPNPrevention of chemotherapyInitiation of chemotherapyMain dose-limiting side effectChart review studyRetrospective chart analysisVA electronic health recordMajor adverse effectsNumber of patientsDuration of survivalCalcium signalingHuman cancer patientsAberrant calcium signalingQuality of lifeElectronic health recordsApplication of drugsProstate Cancer, Comorbidity, and Participation in Randomized Controlled Trials of Therapy
Chao H, Mayer T, Concato J, Rose M, Uchio E, Kelly K. Prostate Cancer, Comorbidity, and Participation in Randomized Controlled Trials of Therapy. Journal Of Investigative Medicine 2010, 58: 566. DOI: 10.2310/jim.0b013e3181cf9002.Peer-Reviewed Original ResearchCastrate-resistant prostate cancerPhase 3 RCTsProstate cancerClinical settingPhase 3 clinical trialsVeterans Affairs Connecticut Healthcare SystemGeneral oncology practiceAbnormal laboratory valuesPopulation of patientsRandomized Controlled TrialsComplete medical recordsSerious medical conditionProportion of menBackground RandomizedChemotherapy regimensCRPC patientsControlled TrialsMedical recordsClinical trialsOncology practiceInclusion criteriaLaboratory valuesCardiac diseaseMedical conditionsClinical care
2009
Activation of the pre-supplementary motor area but not inferior prefrontal cortex in association with short stop signal reaction time – an intra-subject analysis
Chao H, Luo X, Chang J, Li CS. Activation of the pre-supplementary motor area but not inferior prefrontal cortex in association with short stop signal reaction time – an intra-subject analysis. BMC Neuroscience 2009, 10: 75. PMID: 19602259, PMCID: PMC2719646, DOI: 10.1186/1471-2202-10-75.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeRight inferior prefrontal cortexStop-signal taskPre-supplementary motor areaShorter stop-signal reaction timesInferior prefrontal cortexSignal reaction timePrefrontal cortexResponse inhibitionMotor areaMiddle/posterior cingulate cortexMotor response inhibitionInferior frontal cortexRegional brain activationStop-signal inhibitionLonger stop-signal reaction timesInhibitory motor controlPosterior cingulate cortexMedial prefrontal cortexReaction timeGreater activityAttentional monitoringNeural processesSignal taskBrain activation
2008
Neural Correlates of Speeded as Compared with Delayed Responses in a Stop Signal Task: An Indirect Analog of Risk Taking and Association with an Anxiety Trait
Li CS, Chao H, Lee TW. Neural Correlates of Speeded as Compared with Delayed Responses in a Stop Signal Task: An Indirect Analog of Risk Taking and Association with an Anxiety Trait. Cerebral Cortex 2008, 19: 839-848. PMID: 18678764, PMCID: PMC2722793, DOI: 10.1093/cercor/bhn132.Peer-Reviewed Original ResearchConceptsStop-signal taskSignal taskReaction timeTrial reaction timeStop-signal performanceFunctional magnetic resonanceMiddle frontal gyrusAdvantage of variabilityBilateral visual cortexPosterior cingulate cortexCognitive controlNeural correlatesNeural processesAmygdala activityTrait anxietyFrontal gyrusAnxiety traitsBehavioral paradigmsIndirect analogueCingulate cortexNeural analogRisk takingVisual cortexStop signalCurrent studyError-specific medial cortical and subcortical activity during the stop signal task: A functional magnetic resonance imaging study
Li C, Yan P, Chao H, Sinha R, Paliwal P, Constable RT, Zhang S, Lee T. Error-specific medial cortical and subcortical activity during the stop signal task: A functional magnetic resonance imaging study. Neuroscience 2008, 155: 1142-1151. PMID: 18674592, PMCID: PMC2605269, DOI: 10.1016/j.neuroscience.2008.06.062.Peer-Reviewed Original ResearchConceptsPost-error behavioral adjustmentPost-error slowingBehavioral adjustmentSignal taskFunctional magnetic resonance imaging studyConflict monitoring hypothesisError-related activityFunctional magnetic resonance imagingHigh-conflict trialsTrial reaction timeStop-signal taskMedial cortical regionsCortical brain regionsMagnetic resonance imaging studyResonance imaging studyElicit errorsBrain activationLess activationSubcortical activityCortical activityRetrosplenial cortexMonitoring hypothesisBehavioral outputBrain regionsCortical regions
2000
Loss of p19 ARF Eliminates the Requirement for the pRB-Binding Motif in Simian Virus 40 Large T Antigen-Mediated Transformation
Chao H, Buchmann A, DeCaprio J. Loss of p19 ARF Eliminates the Requirement for the pRB-Binding Motif in Simian Virus 40 Large T Antigen-Mediated Transformation. Molecular And Cellular Biology 2000, 20: 7624-7633. PMID: 11003658, PMCID: PMC86324, DOI: 10.1128/mcb.20.20.7624-7633.2000.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAnimalsAntigens, Viral, TumorBlotting, WesternCarrier ProteinsCell CountCell Cycle ProteinsCell DivisionCell Line, TransformedCell Transformation, NeoplasticContact InhibitionCyclin-Dependent Kinase Inhibitor p16DNA-Binding ProteinsE2F Transcription FactorsFibroblastsGene DeletionGene Expression Regulation, NeoplasticGenes, ReporterMicePromoter Regions, GeneticProtein BindingProteinsRetinoblastoma ProteinRetinoblastoma-Binding Protein 1Transcription Factor DP1Transcription FactorsTumor Suppressor Protein p14ARFTumor Suppressor Protein p53ConceptsMouse embryo fibroblastsLXCXE motifP53-binding domainJ-domainT antigenCellular transformationSequence-specific transcription factorsWild-type T antigenRetinoblastoma protein familyN-terminal 70 residuesHsp40/DnaJPRB family membersSimian virus 40 large T antigenAbility of p53Anchorage-independent growthLarge T antigenProtein familySignificant homologyTranscription factorsTerminal domainPRB-bindingPRb familyMutant derivativesMutant formsTumor suppressorpRB-Dependent, J Domain-Independent Function of Simian Virus 40 Large T Antigen in Override of p53 Growth Suppression
Gjoerup O, Chao H, DeCaprio J, Roberts T. pRB-Dependent, J Domain-Independent Function of Simian Virus 40 Large T Antigen in Override of p53 Growth Suppression. Journal Of Virology 2000, 74: 864-874. PMID: 10623749, PMCID: PMC111607, DOI: 10.1128/jvi.74.2.864-874.2000.Peer-Reviewed Original Research