2024
Cerebral Proteomic Changes in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 With Cortical Microhemorrhages and Cognitive Impairments
Schrader J, Majchrzak M, Xu F, Lee H, Agostinucci K, Davis J, Benveniste H, Van Nostrand W. Cerebral Proteomic Changes in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 With Cortical Microhemorrhages and Cognitive Impairments. Neuroscience Insights 2024, 19: 26331055241288172. PMID: 39386146, PMCID: PMC11462563, DOI: 10.1177/26331055241288172.Peer-Reviewed Original ResearchCerebral amyloid angiopathyPathogenesis of cerebral amyloid angiopathyTGF-b1Rat modelTGF-b1 levelsType 2Few proteinsSmooth muscle cell lossTransforming growth factor beta 1Wild-type ratsProteomic changesB proteinProteomic analysisPeptidase ATransgenic rat modelPathway analysisMolecular insightsMagnetic resonance imagingCognitive impairmentAlzheimer's diseaseCell lossAmyloid depositsRatsAmyloid angiopathyCortical microhemorrhages
2021
Transgenic rat models for cerebral amyloid angiopathy type‐1 and ‐2 and related vascular cognitive impairment and dementia (VCID)
Van Nostrand W, Xu F, Lee H, Robinson J, Benveniste H. Transgenic rat models for cerebral amyloid angiopathy type‐1 and ‐2 and related vascular cognitive impairment and dementia (VCID). Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.051368.Peer-Reviewed Original ResearchCerebral amyloid angiopathyType 2 ratsWhite matter lossType 1 ratsMonths of ageCAA type 1Vascular cognitive impairmentTransgenic rat modelMagnetic resonance imagingType 1CAA pathologyCerebral microbleedsPathological featuresRat modelTypes of CAAType 2Cognitive impairmentCerebral small vessel diseaseHistological analysisNovel transgenic rat modelSmall vessel diseaseWhite matter changesReliable preclinical modelsCognitive changesParticular pathological features
2009
DETECTION OF Ca2+-DEPENDENT NEURONAL ACTIVITY SIMULTANEOUSLY WITH DYNAMIC CHANGES IN CEREBRAL BLOOD VOLUME AND TISSUE OXYGENATION FROM THE LIVE RAT BRAIN
DU C, LUO Z, YU M, BENVENISTE H, TULLY M, PAN R, CHANCE B. DETECTION OF Ca2+-DEPENDENT NEURONAL ACTIVITY SIMULTANEOUSLY WITH DYNAMIC CHANGES IN CEREBRAL BLOOD VOLUME AND TISSUE OXYGENATION FROM THE LIVE RAT BRAIN. Journal Of Innovative Optical Health Sciences 2009, 2: 189-200. DOI: 10.1142/s1793545809000498.Peer-Reviewed Original ResearchCerebral blood volumeFunctional magnetic resonance imagingRat brainTissue oxygenationBlood volumeElectrical forepaw stimulationMagnetic resonance imagingLevel-dependent responsesHemodynamic changesCortical brainBrain functional studiesForepaw stimulationIntracellular calciumSomatosensory responsesNeuronal activityStroke experimentsResonance imagingFunctional changesBrainBrain activationLive rat brainBrain responsesNew modalityOxygenationStimulation
2007
Development of Ventricular Expansion and Increased Pulsatile CSF Flow in a Rat Model
Rashid S, Wagshul M, Yu M, Benveniste H, Li J, McAllister J. Development of Ventricular Expansion and Increased Pulsatile CSF Flow in a Rat Model. 2007, 96-97. DOI: 10.1109/nebc.2007.4413296.Peer-Reviewed Original ResearchEvolution of a Focal Brain Lesion Produced by Interlaced Microplanar X-Rays
Anschel D, Romanelli P, Benveniste H, Foerster B, Kalef-Ezra J, Zhong Z, Dilmanian F. Evolution of a Focal Brain Lesion Produced by Interlaced Microplanar X-Rays. Min - Minimally Invasive Neurosurgery 2007, 50: 43-46. PMID: 17546543, DOI: 10.1055/s-2007-976514.Peer-Reviewed Original ResearchConceptsT2 signalCentral nervous system diseaseHigh T2 signalNervous system diseasesTesla magnetic resonance imagingFocal brain lesionsMagnetic resonance imagingBrain lesionsRadiosurgical approachRat brainSystem diseasesStereotactic radiosurgeryHigh-dose irradiationFuture treatmentLow dosesLesionsResonance imagingLow T1Dose irradiationBrainTreatmentPrecise targetsX-ray
2001
Tracking Brain Volume Changes in C57BL/6J and ApoE-Deficient Mice in a Model of Neurodegeneration: A 5-Week Longitudinal Micro-MRI Study
McDaniel B, Sheng H, Warner D, Hedlund L, Benveniste H. Tracking Brain Volume Changes in C57BL/6J and ApoE-Deficient Mice in a Model of Neurodegeneration: A 5-Week Longitudinal Micro-MRI Study. NeuroImage 2001, 14: 1244-1255. PMID: 11707081, DOI: 10.1006/nimg.2001.0934.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins EAtrophyBrainBrain IschemiaBrain MappingCerebral VentriclesDisease Models, AnimalHippocampusImage EnhancementImage Processing, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMice, Neurologic MutantsMicroscopyNeurodegenerative DiseasesProsencephalonConceptsApoE-deficient miceModels of neurodegenerationPostischemic dayBrain atrophyMouse modelNeurodegenerative diseasesDorsal hippocampal volumeBrain volume changesMin of ischemiaHigh signal intensity areaTransgenic mouse modelProgression of pathologyCorresponding time pointsSignal intensity areaMagnetic resonance imagingHigh-resolution MRIT1-weighted MR imagingC57 miceDorsal hippocampusHippocampal volumeClinical conditionsIschemiaMRI studiesPredetermined protocolCognitive decline
1991
Quantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain.
Benveniste H, Cofer G, Piantadosi C, Davis J, Johnson G. Quantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain. Stroke 1991, 22: 259-268. PMID: 2003291, DOI: 10.1161/01.str.22.2.259.Peer-Reviewed Original ResearchConceptsSelective neuronal injuryFocal cerebral ischemiaArea of injuryCerebral ischemiaNeuronal injuryTotal slice areaIschemic penumbraWistar ratsRat brainCresyl violet-stained brain sectionsMR imagingUpper cortical layersMale Wistar ratsPermanent unilateral occlusionCommon carotid arteryHistological sectionsArea of infarctionMR imagesNormal brain tissueMagnetic resonance imagingCerebral cortexUnilateral occlusionHistological damageHalothane anesthesiaCarotid artery