2022
Impact of drug adherence on blood pressure response to alcohol-mediated renal denervation
Persu A, Maes F, Toennes S, Ritscher S, Georges C, Wallemacq P, Haratani N, Parise H, Fischell T, Lauder L, Mahfoud F. Impact of drug adherence on blood pressure response to alcohol-mediated renal denervation. Blood Pressure 2022, 31: 109-117. PMID: 35575248, DOI: 10.1080/08037051.2022.2074367.Peer-Reviewed Original ResearchConceptsRenal denervationDrug adherenceBlood pressure changesNon-adherent patientsPoor drug adherenceTreatment-resistant hypertensionSham-controlled trialBlood pressure responseSystolic blood pressureUncontrolled hypertensionAntihypertensive medicationsResistant hypertensionSuch patientsBlood pressureAntihypertensive drugsDenervationMean 24Partial adherencePatientsFull adherenceUrinary detectionHypertensionPressure changesLiquid chromatography-tandem mass spectrometryAdherence
2020
Evaluation of Transcatheter Alcohol-Mediated Perivascular Renal Denervation to Treat Resistant Hypertension
Janas A, Król M, Hochuł M, Jochymczyk M, Hayward-Costa C, Parise H, Haratani N, Fischell T, Wojakowski W. Evaluation of Transcatheter Alcohol-Mediated Perivascular Renal Denervation to Treat Resistant Hypertension. Journal Of Clinical Medicine 2020, 9: 1881. PMID: 32560164, PMCID: PMC7356226, DOI: 10.3390/jcm9061881.Peer-Reviewed Original ResearchAmbulatory blood pressure monitoringRenal denervationResistant hypertensionOffice BPCatheter-based renal denervationBlood pressure monitoringRenal artery anatomyHypothesis-generating studyContrast computer tomographyAnti-hypertension drugsNephrologist consultationResistant HTNAdult patientsSympathetic nervesSystolic pressureHypertension treatmentRenal arteryArtery anatomyAdventitial spaceMean decreasePressure monitoringPatientsDenervationHypertensionVariable success
2018
CHEMICAL RENAL DENERVATION WITH ALCOHOL – LONG TERM RESULTS FROM THE PEREGRINE POST-MARKET STUDY
Persu A, Renkin J, Hochul M, Wojakowski W, Böhm M, Mahfoud F, Schmieder R, van der Giet M, de Bucourt M, Zirlik A, Neuzil P, Haratani N, Parise H, Fischell T, Bertog S, Sievert K, Sievert H. CHEMICAL RENAL DENERVATION WITH ALCOHOL – LONG TERM RESULTS FROM THE PEREGRINE POST-MARKET STUDY. Journal Of Hypertension 2018, 36: e123. DOI: 10.1097/01.hjh.0000539319.18701.45.Peer-Reviewed Original ResearchSystolic office blood pressureChemical renal denervationResistant hypertensionPost-market studyRenal denervationVascular access site complicationsWhite-coat resistant hypertensionMajor efficacy endpointsMulticenter European trialSignificant BP reductionOffice blood pressureRenal artery dissectionTransient ischemic attackAccess site complicationsAnti-hypertensive medicationsMean procedure timeMajor safety endpointsML of alcoholAnatomical eligibilityAntihypertensive medicationsBP reductionEligible patientsIschemic attackOpen labelRenal events