2007
Associations of Plasma Natriuretic Peptide, Adrenomedullin, and Homocysteine Levels With Alterations in Arterial Stiffness
Levy D, Hwang S, Kayalar A, Benjamin E, Vasan R, Parise H, Larson M, Wang T, Selhub J, Jacques P, Vita J, Keyes M, Mitchell G. Associations of Plasma Natriuretic Peptide, Adrenomedullin, and Homocysteine Levels With Alterations in Arterial Stiffness. Circulation 2007, 115: 3079-3085. PMID: 17533184, DOI: 10.1161/circulationaha.106.652842.Peer-Reviewed Original ResearchConceptsN-terminal atrial natriuretic peptideCarotid-femoral pulse wave velocityB-type natriuretic peptidePulse wave velocityAtrial natriuretic peptideCarotid-radial pulse wave velocityCentral pulse pressurePlasma natriuretic peptidesNatriuretic peptideArterial stiffnessHomocysteine levelsPulse pressureFramingham Heart StudyHeart StudyPlasma N-terminal atrial natriuretic peptideDiastolic blood pressureMean arterial pressureCarotid pulse pressureArterial wall stiffnessForward pressure waveArterial pressureCentral systolicBlood pressureHomocysteine concentrationsCardiovascular disease
2005
Cross-Sectional Association of Kidney Function with Valvular and Annular Calcification: The Framingham Heart Study
Fox C, Larson M, Vasan R, Guo C, Parise H, Levy D, Leip E, O’Donnell C, D’Agostino R, Benjamin E. Cross-Sectional Association of Kidney Function with Valvular and Annular Calcification: The Framingham Heart Study. Journal Of The American Society Of Nephrology 2005, 17: 521-527. PMID: 16382018, DOI: 10.1681/asn.2005060627.Peer-Reviewed Original ResearchConceptsMitral annular calcificationAortic annular calcificationAnnular calcificationValvular calcificationKidney diseaseAortic sclerosisKidney functionPresence of MACTotal/HDL cholesterolVascular risk factor burdenRenal Disease Study equationEnd-stage kidney diseaseRisk factor burdenCardiovascular risk factorsCardiovascular disease eventsChronic kidney diseaseEarly kidney diseaseBody mass indexOnset of ESRDFramingham Offspring StudyTwo-dimensional echocardiographyFramingham Heart StudyDiastolic BPHDL cholesterolHypertension treatment
2004
Parental Atrial Fibrillation as a Risk Factor for Atrial Fibrillation in Offspring
Fox C, Parise H, D'Agostino R, Lloyd-Jones D, Vasan R, Wang T, Levy D, Wolf P, Benjamin E. Parental Atrial Fibrillation as a Risk Factor for Atrial Fibrillation in Offspring. JAMA 2004, 291: 2851-2855. PMID: 15199036, DOI: 10.1001/jama.291.23.2851.Peer-Reviewed Original ResearchConceptsAtrial fibrillationOffspring participantsNew-onset atrial fibrillationPopulation-based epidemiologic studyAntecedent myocardial infarctionCommon cardiac dysrhythmiaProspective cohort studyYears of ageFramingham Heart StudyFamilial atrial fibrillationCohort studyHeart failureCardiac dysrhythmiasMyocardial infarctionOriginal cohortRisk factorsEpidemiologic studiesRare caseHeart StudyGenetic susceptibilityFibrillationUnselected individualsGenetic factorsDysrhythmiasFuture riskMitral annular calcification is a predictor for incident atrial fibrillation
Fox C, Parise H, Vasan R, Levy D, O’Donnell C, D’Agostino R, Plehn J, Benjamin E. Mitral annular calcification is a predictor for incident atrial fibrillation. Atherosclerosis 2004, 173: 291-294. PMID: 15064104, DOI: 10.1016/j.atherosclerosis.2003.12.018.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAged, 80 and overAtrial FibrillationCalcinosisCohort StudiesComorbidityEchocardiography, DopplerElectrocardiographyFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedMitral Valve StenosisProbabilityProportional Hazards ModelsRetrospective StudiesRisk AssessmentSeverity of Illness IndexSex DistributionConceptsMitral annular calcificationIncident atrial fibrillationAtrial fibrillationAnnular calcificationAdverse cardiovascular disease outcomesSex-adjusted incidence ratesRisk of AFLeft atrial sizeMultivariable-adjusted analysesCardiac valvular calcificationCardiovascular disease outcomesCommunity-based cohortM-mode echocardiographyProportional hazards modelLong-term riskFramingham Heart StudyIncident AFHazard ratioAtrial enlargementAtrial sizeEchocardiographic assessmentValvular calcificationOriginal cohortProspective dataIncidence rate
2003
Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study
Roubenoff R, Parise H, Payette H, Abad L, D'Agostino R, Jacques P, Wilson P, Dinarello C, Harris T. Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. The American Journal Of Medicine 2003, 115: 429-435. PMID: 14563498, DOI: 10.1016/j.amjmed.2003.05.001.Peer-Reviewed Original ResearchConceptsIGF-1 levelsInsulin-like growth factor-1Growth factor-1Fat-free massFramingham Heart StudyMass indexInterleukin-6TNF-alphaHeart StudyHigh serum interleukin-6 levelsHigher serum IGF-1 levelsBlood mononuclear cell productionOlder community-dwelling menSerum IGF-1 levelsSerum interleukin-6 levelsCommunity-dwelling older personsFat-free mass indexCommunity-dwelling elderly adultsSerum interleukin-6Interleukin-6 levelsCommunity-dwelling menMononuclear cell productionBody mass indexCytokines TNF-alphaFactor 1