2024
The extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries
Dorr D, Markwardt S, Bobo M, Allore H, Botoseneanu A, Newsom J, Nagel C, Quiñones A. The extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries. BMC Geriatrics 2024, 24: 777. PMID: 39304796, PMCID: PMC11414248, DOI: 10.1186/s12877-024-05329-y.Peer-Reviewed Original ResearchConceptsHigh multimorbidityMultimorbidity levelOlder adultsHigher levels of multimorbidityHealth and Retirement Study dataAssociated with sociodemographic characteristicsWell-being of older adultsLevels of multimorbidityProgression of multimorbidityImpact of multimorbidityBurden of multimorbidityHigher healthcare utilizationRetirement Study dataYounger birth cohortsMultimorbidity groupsHealthcare utilizationLower educationNon-HispanicMultimorbiditySociodemographic characteristicsMedicare beneficiariesSocioeconomic statusHealth indicatorsBirth cohortChronic diseasesMultimorbidity and associated informal care receiving characteristics for US older adults: a latent class analysis
Liu R, Nagel C, Chen S, Newsom J, Allore H, Quiñones A. Multimorbidity and associated informal care receiving characteristics for US older adults: a latent class analysis. BMC Geriatrics 2024, 24: 571. PMID: 38956501, PMCID: PMC11221032, DOI: 10.1186/s12877-024-05158-z.Peer-Reviewed Original ResearchConceptsNational Health and Aging Trends StudyMultimorbidity patternsCare needsOlder adultsSelf-careInformal careLatent class analysisCare receiver characteristicsCombinations of multimorbidityPerson-centered carePatterns of multimorbidityDifferential care needsUS older adultsAssociated with lower oddsAssociated with higher oddsGroup of older adultsMultinomial logistic regression modelModerate cognitive impairmentClass analysisLogistic regression modelsInformal caregiversBackgroundOlder adultsCare recipientsMultimorbidity groupsChronic conditionsMental-somatic multimorbidity in trajectories of cognitive function for middle-aged and older adults
Chen S, Nagel C, Liu R, Botoseneanu A, Allore H, Newsom J, Thielke S, Kaye J, Quiñones A. Mental-somatic multimorbidity in trajectories of cognitive function for middle-aged and older adults. PLOS ONE 2024, 19: e0303599. PMID: 38743678, PMCID: PMC11093294, DOI: 10.1371/journal.pone.0303599.Peer-Reviewed Original ResearchConceptsOdds of cognitive impairmentGroup-based trajectory modelingMultimorbidity combinationsLate-life increaseOlder adultsNon-Hispanic white adultsHigh riskHealth and Retirement StudyMiddle-agedHealth-related factorsTrajectories of cognitive functionCognitive declineCognitive impairmentMultinomial logistic regression modelMultinomial logistic regression analysisLow riskLogistic regression modelsLow initial riskTrajectory group membershipLogistic regression analysisRetirement StudyNon-HispanicMultimorbidityWhite adultsHispanic respondentsRecommendations on Methods for Assessing Multimorbidity Changes Over Time: Aligning the Method to the Purpose
Nagel C, Bishop N, Botoseneanu A, Allore H, Newsom J, Dorr D, Quiñones A. Recommendations on Methods for Assessing Multimorbidity Changes Over Time: Aligning the Method to the Purpose. The Journals Of Gerontology Series A 2024, 79: glae122. PMID: 38742711, PMCID: PMC11163923, DOI: 10.1093/gerona/glae122.Peer-Reviewed Original ResearchConceptsStudy of multimorbidityHealth-related quality of lifeMeasures of multimorbidityEffect of multimorbidityPerson-centered outcomesHealth-related outcomesHealth-related qualityLongitudinal studyQuality of lifeHealth-related dataMultimorbidity researchHealth domainsMultimorbidityLate-lifePeriod of changeAging populationOperationalizing changeLongitudinal analysisLongitudinal changesMore advanced stagesQuantitative studyOutcomesResearch objectHealthPractical issues
2023
Phenotyping Self-Reported Health Profiles in Octogenarians and Nonagenarians After Percutaneous Coronary Intervention: A Latent Profile Analysis
Instenes I, Breivik K, Borregaard B, Larsen A, Allore H, Bendz B, Deaton C, Rotevatn S, Norekvål T, investigators C. Phenotyping Self-Reported Health Profiles in Octogenarians and Nonagenarians After Percutaneous Coronary Intervention: A Latent Profile Analysis. Heart Lung And Circulation 2023, 32: 1321-1333. PMID: 37925313, DOI: 10.1016/j.hlc.2023.09.004.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPoor health profileBetter health profileSelf-reported healthLow exercise levelsHealth profileCoronary interventionExercise levelsOlder adultsLow alcohol intakeLogistic regression analysisReal-world studyDifferent health outcomesMultinomial logistic regression analysisPatient characteristicsAlcohol intakeHealth outcomesHealth statusOctogenariansOlder ageNonagenariansMost participantsMonthsRegression analysisStandardised measuresAssociations between dementia staging, neuropsychiatric behavioral symptoms, and divorce or separation in late life: A case control study
Monin J, McAvay G, Zang E, Vander Wyk B, Carrión C, Allore H. Associations between dementia staging, neuropsychiatric behavioral symptoms, and divorce or separation in late life: A case control study. PLOS ONE 2023, 18: e0289311. PMID: 37585365, PMCID: PMC10431668, DOI: 10.1371/journal.pone.0289311.Peer-Reviewed Original ResearchConceptsAdjusted odds ratioAlzheimer's Disease Research CenterAgitation/aggressionDepression/dysphoriaCase-control studyElation/euphoriaNational Alzheimer's Coordinating CenterDisease Research CenterBehavioral symptomsDivorce/separationOlder adultsCoordinating CenterDementia stagingConditional logistic regressionStages of dementiaCase/control statusInitial visitOdds ratioIndividual symptomsNPI scoresStandardized clinical informationClinical informationMarried casesGreater oddsControl studyAssociations Between Frailty and the Increased Risk of Adverse Outcomes Among 38,950 UK Biobank Participants With Prediabetes: Prospective Cohort Study
Cao X, Li X, Zhang J, Sun X, Yang G, Zhao Y, Li S, Hoogendijk E, Wang X, Zhu Y, Allore H, Gill T, Liu Z. Associations Between Frailty and the Increased Risk of Adverse Outcomes Among 38,950 UK Biobank Participants With Prediabetes: Prospective Cohort Study. JMIR Public Health And Surveillance 2023, 9: e45502. PMID: 37200070, PMCID: PMC10236284, DOI: 10.2196/45502.Peer-Reviewed Original ResearchConceptsMultiple adverse outcomesChronic kidney diseaseDiabetes-related microvascular diseaseAdverse outcomesCause mortalityCardiovascular diseaseMiddle-aged adultsUK Biobank participantsHigh riskMicrovascular diseaseEye diseaseIncident type 2 diabetes mellitusType 2 diabetes mellitusProportional hazards regression modelsBiobank participantsMultivariable-adjusted modelsProspective cohort studyHazards regression modelsNormal glucose metabolismDiabetes-related burdenDiabetes-related diseasesHealth care resourcesNonfrail counterpartsFrailty assessmentCohort studyAntibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdultsPlatelet response to influenza vaccination reflects effects of aging
Konstorum A, Mohanty S, Zhao Y, Melillo A, Vander Wyk B, Nelson A, Tsang S, Blevins T, Belshe R, Chawla D, Rondina M, Gill T, Montgomery R, Allore H, Kleinstein S, Shaw A. Platelet response to influenza vaccination reflects effects of aging. Aging Cell 2023, 22: e13749. PMID: 36656789, PMCID: PMC9924941, DOI: 10.1111/acel.13749.Peer-Reviewed Original ResearchConceptsCommunity-dwelling older adultsPlatelet activationOlder adultsInfluenza vaccinationAge-associated chronic inflammationInfluence platelet functionRNA expressionPro-inflammatory diseasesAge-associated increasePlatelet activation pathwaysAge-associated differencesActivation pathwayPlatelet transcriptomeGeriatric conditionsChronic inflammationImmune responsePlatelet functionPlatelet responseSNF residentsVaccinationActivation responseYoung individualsProtein levelsAdultsYounger participants
2022
Depressive Multimorbidity and Trajectories of Functional Status among Older Americans: Differences by Racial/Ethnic Group
Botoseneanu A, Elman M, Allore H, Dorr D, Newsom J, Nagel C, Quiñones A. Depressive Multimorbidity and Trajectories of Functional Status among Older Americans: Differences by Racial/Ethnic Group. Journal Of The American Medical Directors Association 2022, 24: 250-257.e3. PMID: 36535384, PMCID: PMC10280885, DOI: 10.1016/j.jamda.2022.11.015.Peer-Reviewed Original ResearchConceptsFunctional limitationsOlder adultsSomatic multimorbidityBody mass indexScreening/treatmentDaily living limitationsUS older adultsNon-Hispanic blacksHigher depressive symptomsAdults age 65Race/ethnicityMass indexTreatment optionsBaseline ageFunctional statusRepresentative sampleHigh prevalenceInstrumental activitiesFunctional declineDaily livingMultimorbidityDepressive symptomsSomatic diseasesDepressive symptomatologyEthnic groupsDigital phenotyping by wearable-driven artificial intelligence in older adults and people with Parkinson’s disease: Protocol of the mixed method, cyclic ActiveAgeing study
Torrado JC, Husebo BS, Allore HG, Erdal A, Fæø SE, Reithe H, Førsund E, Tzoulis C, Patrascu M. Digital phenotyping by wearable-driven artificial intelligence in older adults and people with Parkinson’s disease: Protocol of the mixed method, cyclic ActiveAgeing study. PLOS ONE 2022, 17: e0275747. PMID: 36240173, PMCID: PMC9565381, DOI: 10.1371/journal.pone.0275747.Peer-Reviewed Original ResearchConceptsREM Sleep Behavior Disorder Screening QuestionnaireUnified Parkinson's Disease Rating ScaleDisease Rating ScaleGeriatric Depression ScaleApathy Evaluation ScaleParkinson's diseaseOlder adultsGeriatric Anxiety InventoryParkinson's Disease Rating ScaleClinical assessment scalesMontreal Cognitive AssessmentNew outcome measureQuality of lifeGlobal public healthHealthy older adultsClinical trialsOutcome measuresDepression ScaleLifestyle changesScreening QuestionnaireWaiting listFunctional limitationsSymptom evolutionNeurological disordersAssessment ScalePerceptions of generic medicines and medication adherence after percutaneous coronary intervention: a prospective multicentre cohort study
Pettersen TR, Schjøtt J, Allore HG, Bendz B, Borregaard B, Fridlund B, Larsen AI, Nordrehaug JE, Rotevatn S, Wentzel-Larsen T, Norekvål TM. Perceptions of generic medicines and medication adherence after percutaneous coronary intervention: a prospective multicentre cohort study. BMJ Open 2022, 12: e061689. PMID: 36127123, PMCID: PMC9490600, DOI: 10.1136/bmjopen-2022-061689.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionProspective multicentre cohort studyMulticentre cohort studyMedication adherenceCohort studyCoronary interventionFemale sexGeneric medicinesSelf-reported medication adherenceOlder ageSelf-reported health statusLow socioeconomic statusPoor mental healthLow education levelSecondary outcomesPCI centerBrand-name medicinesClinical variablesMean agePatients' perceptionsMAIN OUTCOMEHealth statusMental healthSocioeconomic statusTime pointsThe Contribution of Chronic Conditions to Hospitalization, Skilled Nursing Facility Admission, and Death: Variation by Race
Quiñones AR, McAvay GJ, Peak KD, Vander Wyk B, Allore HG. The Contribution of Chronic Conditions to Hospitalization, Skilled Nursing Facility Admission, and Death: Variation by Race. American Journal Of Epidemiology 2022, 191: 2014-2025. PMID: 35932162, PMCID: PMC10144669, DOI: 10.1093/aje/kwac143.Peer-Reviewed Original ResearchConceptsSkilled nursing facility admissionsNursing facility admissionsChronic conditionsFacility admissionMedicare beneficiariesCostly health care utilizationHealth care utilizationRacial differencesNon-Hispanic blacksWhite Medicare beneficiariesAverage attributable fractionHealth-related outcomesImportant health-related outcomesNon-Hispanic White older adultsWhite older adultsAging Trends StudyMultimorbidity burdenRenal morbidityOngoing careAttributable fractionNational HealthCardiovascular conditionsOlder adultsImportant markerHospitalizationCatastrophic health expenditure among Chinese adults living alone with cognitive impairment: findings from the CHARLS
Li C, Jin S, Cao X, Han L, Sun N, Allore H, Hoogendijk EO, Xu X, Feng Q, Liu X, Liu Z. Catastrophic health expenditure among Chinese adults living alone with cognitive impairment: findings from the CHARLS. BMC Geriatrics 2022, 22: 640. PMID: 35922775, PMCID: PMC9351200, DOI: 10.1186/s12877-022-03341-8.Peer-Reviewed Original ResearchEmergency Department Care Transitions for Patients With Cognitive Impairment: A Scoping Review
Gettel CJ, Falvey JR, Gifford A, Hoang L, Christensen LA, Hwang U, Shah MN, Network T, Aggarawal N, Allore H, Amy A, Belleville M, Bellolio M, Betz M, Biese K, Brandt C, Bruursema S, Carnahan R, Carpenter C, Carr D, Chin-Hansen J, Daven M, Degesys N, Dresden M, Dussetschleger J, Ellenbogen M, Falvey J, Foster B, Gettel C, Gifford A, Gilmore-Bykovskyi A, Goldberg E, Han J, Hardy J, Hastings S, Hirshon J, Hoang L, Hogan T, Hung W, Hwang U, Isaacs E, Jaspal N, Jobe D, Johnson J, Kelly K, Kennedy M, Kind A, Leggett J, Malone M, Moccia M, Moreno M, Morrow-Howell N, Nowroozpoor A, Ohuabunwa U, Oiyemhonian B, Perry W, Prusaczk B, Resendez J, Rising K, Sano M, Savage B, Shah M, Suyama J, Swartzberg J, Taylor Z, Vaishal T, Vann A, Webb T, Weintraub S. Emergency Department Care Transitions for Patients With Cognitive Impairment: A Scoping Review. Journal Of The American Medical Directors Association 2022, 23: 1313.e1-1313.e13. PMID: 35247358, PMCID: PMC9378565, DOI: 10.1016/j.jamda.2022.01.076.Peer-Reviewed Original ResearchConceptsCare transition interventionsRelevant patient-centered outcomesPatient-centered outcomesCognitive impairmentCare partnersTransition interventionsCare transitionsOlder adultsEmergency Department Care TransitionsED revisit ratesSystematic electronic searchFull-text reviewScoping ReviewMedical research databasesGeriatric assessmentSecondary outcomesSystematic scoping reviewED careED patientsED settingPhysical functionFuture investigationsCare coordinationOutpatient careEligible studiesRisk Factors of Skilled Nursing Facility Admissions and the Interrelation With Hospitalization and Amount of Informal Caregiving Received
Cao Y, Allore H, Gutman R, Vander Wyk B, Jørgensen TSH. Risk Factors of Skilled Nursing Facility Admissions and the Interrelation With Hospitalization and Amount of Informal Caregiving Received. Medical Care 2022, 60: 294-301. PMID: 35149662, PMCID: PMC8916995, DOI: 10.1097/mlr.0000000000001697.Peer-Reviewed Original ResearchConceptsSkilled nursing facility admissionsNursing facility admissionsNumber of hospitalizationsSNF admissionImportant risk factorRisk factorsHospital admissionFacility admissionNon-Hispanic white race/ethnicityWhite race/ethnicityInformal caregivingWeak positive correlationDaily living (ADL) disabilityPossible risk factorsPositive correlationAging Trends StudyRace/ethnicityObservational followStrong positive correlationNational HealthAdmissionDementia diagnosisHospitalizationAlzheimer's diseaseHealth factors
2021
Association Between Potentially Inappropriate Medications and 30-Day Post–Hospital Discharge Outcomes in US Veterans
Allore HG, Gnjidic D, Skanderson M, Han L. Association Between Potentially Inappropriate Medications and 30-Day Post–Hospital Discharge Outcomes in US Veterans. Annals Of Pharmacotherapy 2021, 56: 256-263. PMID: 34282638, PMCID: PMC8770754, DOI: 10.1177/10600280211032072.Peer-Reviewed Original ResearchConceptsAdjusted hazard ratioRisk of mortalityHospital dischargeMean ageAcute care hospital readmissionPrimary care clinic visitsCohort's mean agePrevalence of PIMsInappropriate medication useRisk of readmissionHospital discharge outcomesEmergency room visitsHealth care utilizationAdverse drug eventsCentral nervous systemCause mortalityInappropriate medicationsPIM useClinic visitsHazard ratioProspective cohortDischarge outcomesHospital readmissionMedication useOlder inpatientsRacial and Ethnic Differences in Multimorbidity Changes Over Time
Quiñones AR, Newsom JT, Elman MR, Markwardt S, Nagel CL, Dorr DA, Allore HG, Botoseneanu A. Racial and Ethnic Differences in Multimorbidity Changes Over Time. Medical Care 2021, 59: 402-409. PMID: 33821829, PMCID: PMC8024615, DOI: 10.1097/mlr.0000000000001527.Peer-Reviewed Original ResearchConceptsMinimal diseaseOlder adultsProspective cohort studyHigher depressive symptomsMultimorbidity combinationsEthnic older adultsCohort studyMultimorbidity patternsLung diseaseHeart diseaseRetirement Study respondentsDelay progressionDepressive symptomsMultimorbidityDiseaseLatent class analysisLatent classesEthnic differencesWhite AmericansStudy respondentsMultinomial logistic modelAdultsClass analysisLogistic modelParticipants
2020
Individual Heterogeneity in the Probability of Hospitalization, Skilled Nursing Facility Admission, and Mortality
McAvay GJ, Vander Wyk B, Allore H. Individual Heterogeneity in the Probability of Hospitalization, Skilled Nursing Facility Admission, and Mortality. The Journals Of Gerontology Series A 2020, 76: 1668-1677. PMID: 33320184, PMCID: PMC8361334, DOI: 10.1093/gerona/glaa314.Peer-Reviewed Original ResearchConceptsSkilled nursing facility admissionsNursing facility admissionsChronic kidney diseaseHeart failureFacility admissionKidney diseaseChronic conditionsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseIschemic heart diseaseHealth care utilizationProbability of hospitalizationPulmonary diseaseCare utilizationMortality outcomesPoor outcomeHeart diseaseNational HealthOdds ratioDisease combinationsLongitudinal cohortSociodemographic factorsMedicaid ServicesDiseaseAging StudyReform influences location of death: Interrupted time-series analysis on older adults and persons with dementia
Vroomen J, Kjellstadli C, Allore HG, van der Steen JT, Husebo B. Reform influences location of death: Interrupted time-series analysis on older adults and persons with dementia. PLOS ONE 2020, 15: e0241132. PMID: 33147248, PMCID: PMC7641450, DOI: 10.1371/journal.pone.0241132.Peer-Reviewed Original ResearchConceptsLocation of deathInterrupted time series analysisHome deathOlder adultsCoordination ReformNursing homesNursing home deathsAdults 65 yearsOlder adults 65 yearsHospital deathDeath RegistryNorwegian CausePrimary outcomeAdult decedentsDeath certificatesHospitalDementiaMortality dataCare infrastructureHome careDeathPopulation-level studiesAdultsPublic healthNumber of people