2023
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Young J, Park H, Kim M, Par-Young J, Bartlett H, Kim H, Unlu S, Osmani L, Shin M, Bucala R, van Dyck C, Allore H, Mecca A, You S, Kang I. Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease. Immunity & Ageing 2023, 20: 71. PMID: 38042785, PMCID: PMC10693128, DOI: 10.1186/s12979-023-00396-y.Peer-Reviewed Original ResearchPeripheral bloodT cellsAlzheimer's diseaseEM CD8Memory CD8Gene signatureAge-related immune changesIL-7 receptor alphaEffector memory CD8Strong risk factorT cell expansionAD genesAge-associated expansionImmune changesRisk factorsCD8Dementia patientsIL-7RNeuropsychological testingReceptor alphaNeurocognitive functionRT-qPCR resultsDisease severityPatientsNormal personsImplementation of a Best Practice Advisory to Improve Infection Screening Prior to New Prescriptions of Biologics and Targeted Synthetic Drugs
Baker H, Fine R, Suter F, Allore H, Hsiao B, Chowdhary V, Lavelle E, Chen P, Hintz R, Suter L, Danve A. Implementation of a Best Practice Advisory to Improve Infection Screening Prior to New Prescriptions of Biologics and Targeted Synthetic Drugs. Arthritis Care & Research 2023 PMID: 37382043, DOI: 10.1002/acr.25181.Peer-Reviewed Original ResearchBest practice advisoryHepatitis B virusAutoimmune rheumatic diseasesBPA implementationSynthetic disease-modifying antirheumatic drugsDisease-modifying antirheumatic drugsHepatitis C virus infectionHepatitis B surface antigenC virus infectionUse of biologicsB surface antigenQuality improvement initiativesElectronic health recordsEligible patientsAntirheumatic drugsRheumatic diseasesRheumatology practiceSociety guidelinesB virusPractice advisoryComputerized decision support systemVirus infectionRoutine screeningPatient screeningPatientsAntibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdultsThe association of electronic health literacy with behavioural and psychological coronary artery disease risk factors in patients after percutaneous coronary intervention: a 12-month follow-up study
Brørs G, Dalen H, Allore H, Deaton C, Fridlund B, Norman C, Palm P, Wentzel-Larsen T, Norekvål T. The association of electronic health literacy with behavioural and psychological coronary artery disease risk factors in patients after percutaneous coronary intervention: a 12-month follow-up study. European Heart Journal - Digital Health 2023, 4: 125-135. PMID: 36974270, PMCID: PMC10039428, DOI: 10.1093/ehjdh/ztad010.Peer-Reviewed Original ResearchPercutaneous coronary interventionCoronary artery disease risk factorsCAD risk factorsDisease risk factorsLow eHealth literacyRisk factorsElectronic health literacyCoronary interventionEHealth literacyHealth informationHealth literacyHigh-risk CAD patientsEHealth resourcesLow physical activityProspective longitudinal studyIndex admissionAdult patientsCAD patientsEHealth Literacy ScaleHigh burdenPhysical activityPatient useDepression symptomsPatientsLow burden
2022
RACIAL-ETHNIC VARIATION IN MULTIMORBIDITY PATTERNS AND HEALTHCARE SERVICES AMONG OLDEST-OLD PATIENTS
Cho J, Rahimighazikalayeh G, Allore H. RACIAL-ETHNIC VARIATION IN MULTIMORBIDITY PATTERNS AND HEALTHCARE SERVICES AMONG OLDEST-OLD PATIENTS. Innovation In Aging 2022, 6: 795-795. PMCID: PMC9767161, DOI: 10.1093/geroni/igac059.2870.Peer-Reviewed Original ResearchMultiple chronic conditionsOldest-old patientsHealthcare service utilizationPatterns of multimorbidityClinic visitsEmergency departmentHispanic patientsService utilizationHealthcare systemAge-related risk factorsIntegrated healthcare systemRacial-ethnic variationsMetabolism syndromeWhite patientsBlack patientsMultimorbidity patternsChronic conditionsRisk factorsClinical dataPatientsCare managementAlzheimer's diseaseDiverse patientsRelated dementiaSignificant associationGERONTOLOGIC BIOSTATISTICS: MERGING WITH DATA SCIENCE AND TOWARD PERSONALIZED MEDICINE
Shardell M, Murphy T, Allore H. GERONTOLOGIC BIOSTATISTICS: MERGING WITH DATA SCIENCE AND TOWARD PERSONALIZED MEDICINE. Innovation In Aging 2022, 6: 177-177. PMCID: PMC9770254, DOI: 10.1093/geroni/igac059.708.Peer-Reviewed Original ResearchStudy of older personsEpidemiology of agingHealth-related interventionsAssessment of healthHeterogeneity of treatment effectsOlder personsOlder adultsIndividual sessionsTreatment effectsOlder patientsMultifactorial naturePublished studiesData scienceSessionsMultiple streams of dataStreams of dataMultimodal approachPersonalized medicineProgressive deteriorationIntegration of data scienceBehavioral phenotypesPatientsAgeInteractive visualizationPracticeGeographic Variation in Inpatient Care Utilization, Outcomes and Costs for Dementia Patients Aged 65 Years or Older — China, 2017–2019
Lin Z, Ba F, Allore H, Liu G, Chen X. Geographic Variation in Inpatient Care Utilization, Outcomes and Costs for Dementia Patients Aged 65 Years or Older — China, 2017–2019. China CDC Weekly 2022, 4: 997-1001. PMID: 36483008, PMCID: PMC9709301, DOI: 10.46234/ccdcw2022.202.Peer-Reviewed Original ResearchPatients Aged 65 YearsDementia careInpatient care utilizationPublic health issuePublic health practicePublic health policyDementia managementCare utilizationHealthcare utilizationDisease burdenDementia patientsHealth servicesHealth practicesHealth policyHealth issuesGeographic disparitiesDementiaHealthcare systemHealthcare provisionPatientsPublic healthCareImproved accessOutcomesBurden
2019
Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures
Datta R, Zhu M, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures. American Journal Of Hospice And Palliative Medicine® 2019, 37: 27-33. PMID: 31185722, PMCID: PMC6868290, DOI: 10.1177/1049909119855617.Peer-Reviewed Original ResearchConceptsAdvanced cancerAntibiotic useComfort measuresPoisson regression modelsInfection diagnosisIntensive care unit admissionMultivariable Poisson regression modelsCare unit admissionCohort of patientsUrinary tract infectionGoal-concordant careUnit admissionEnd of lifeHospital lengthOlder patientsTract infectionsLonger LOSMedian ageRegression modelsStay AssociatedAntibiotic exposureLiquid tumorsPatientsCancerCancer typesAntimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures
Datta R, Wang T, Zhu M, Dembry LM, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures. Infection Control And Hospital Epidemiology 2019, 40: 470-472. PMID: 30821230, PMCID: PMC6482377, DOI: 10.1017/ice.2019.22.Peer-Reviewed Original ResearchConceptsUrinary tract infectionIncidence rate ratiosAdvanced cancer patientsAsymptomatic bacteriuriaCancer patientsAntimicrobial therapySymptomatic urinary tract infectionPotential urinary tract infectionTract infectionsInappropriate therapyAntimicrobial daysComfort measuresBacteriuriaCandiduriaCFU/mLPatientsTherapyRate ratioMLInfectionDesign and analysis of longitudinal trials of antimicrobial use at the end of life: to give or not to give?
Juthani-Mehta M, Allore HG. Design and analysis of longitudinal trials of antimicrobial use at the end of life: to give or not to give? Therapeutic Advances In Drug Safety 2019, 10: 2042098618820210. PMID: 30800269, PMCID: PMC6378640, DOI: 10.1177/2042098618820210.Peer-Reviewed Original ResearchTerminal cancer patientsAntimicrobial useEnd of lifePalliative careCancer patientsLongitudinal trialBurden of medicationsCessation of medicationHealth literacy interventionsAntimicrobial therapyAntimicrobial prescribingHealth literacyTrial designComparative trial designTrial dataTrial periodMedicationsPatientsTrialsCareLongitudinal modelingLiteracy interventionsPrescribingTherapyInfection
2016
Individualized Absolute Risk Calculations for Persons with Multiple Chronic Conditions: Embracing Heterogeneity, Causality, and Competing Events
Allore H, McAvay G, Fragoso C, Murphy TE. Individualized Absolute Risk Calculations for Persons with Multiple Chronic Conditions: Embracing Heterogeneity, Causality, and Competing Events. International Journal Of Statistics In Medical Research 2016, 5: 48-55. PMID: 27076862, PMCID: PMC4827855, DOI: 10.6000/1929-6029.2016.05.01.5.Peer-Reviewed Original ResearchMultiple chronic conditionsPatient-centered outcomesPatient reported outcomesAbsolute risk calculationRisk calculatorChronic conditionsMore chronic medical conditionsPopulation of patientsChronic medical conditionsComplex treatment decisionsTreatment effectsPatient characteristicsAbsolute riskReported outcomesTreatment decisionsMedical conditionsPropensity score methodsSpecific treatmentRisk calculationOutcomesCompeting EventsPatientsTreatmentRiskScore method