2020
Rates and Predictors of Patient Underreporting of Hospitalizations During Follow-Up After Acute Myocardial Infarction
Caraballo C, Khera R, Jones PG, Decker C, Schulz W, Spertus JA, Krumholz HM. Rates and Predictors of Patient Underreporting of Hospitalizations During Follow-Up After Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2020, 13: e006231. PMID: 32552061, PMCID: PMC9465954, DOI: 10.1161/circoutcomes.119.006231.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionHospitalization eventsMedical recordsLongitudinal multicenter cohort studyMulticenter cohort studyMedical record abstractionDifferent patient characteristicsHealth care eventsPatients' underreportingTRIUMPH registryAccuracy of reportingCohort studyPatient characteristicsRecord abstractionProspective studyClinical studiesClinical investigationHospitalizationPatientsCare eventsInfarctionEvent ratesParticipantsPredictorsSex Differences in 1‐Year Health Status Following Percutaneous Coronary Intervention in Patients Without Acute Myocardial Infarction: Results From the China PEACE Prospective Study
Zheng X, Dreyer RP, Curtis JP, Liu S, Xu X, Bai X, Li X, Zhang H, Wang S, Masoudi FA, Spertus JA, Li J, Krumholz HM, Group F. Sex Differences in 1‐Year Health Status Following Percutaneous Coronary Intervention in Patients Without Acute Myocardial Infarction: Results From the China PEACE Prospective Study. Journal Of The American Heart Association 2020, 9: e014421. PMID: 32131687, PMCID: PMC7335522, DOI: 10.1161/jaha.119.014421.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute myocardial infarctionSAQ Summary ScoreCoronary interventionHealth status outcomesMyocardial infarctionHealth statusSummary scoresSAQ qualityAngina frequencyStatus outcomesPercutaneous coronary intervention studiesSAQ angina frequency scoreAngina frequency scoreCoronary Intervention StudyMarginal clinical significanceSAQ angina frequencyCardiac risk factorsChinese tertiary hospitalBackground Sex differencesSex differencesMultivariable adjustmentDiabetes mellitusTertiary hospitalLife scores
2019
Association of Diabetes Mellitus With Health Status Outcomes in Young Women and Men After Acute Myocardial Infarction: Results From the VIRGO Study
Ding Q, Funk M, Spatz ES, Whittemore R, Lin H, Lipska KJ, Dreyer RP, Spertus JA, Krumholz HM. Association of Diabetes Mellitus With Health Status Outcomes in Young Women and Men After Acute Myocardial Infarction: Results From the VIRGO Study. Journal Of The American Heart Association 2019, 8: e010988. PMID: 31441351, PMCID: PMC6755841, DOI: 10.1161/jaha.118.010988.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsDiabetes MellitusFemaleHealth StatusHealth Status IndicatorsHumansMaleMental HealthMiddle AgedMyocardial InfarctionPatient Reported Outcome MeasuresPredictive Value of TestsPrevalencePrognosisQuality of LifeRecovery of FunctionRisk AssessmentRisk FactorsSex FactorsSpainTime FactorsUnited StatesYoung AdultConceptsAcute myocardial infarctionEuroQol visual analogue scaleSeattle Angina QuestionnaireDiabetes mellitusForm Health SurveyHealth status outcomesHealth statusVIRGO StudyAnalog scaleMyocardial infarctionHealth SurveyStatus outcomesYoung adultsSAQ angina frequencyCardiovascular risk factorsHealth status scoresRisk of mortalityWorse health statusPoor health statusQuality of lifeWorse anginaAngina QuestionnaireClinical characteristicsHealthcare useStatus scoreThirty-Day Readmission Risk Model for Older Adults Hospitalized With Acute Myocardial Infarction
Dodson JA, Hajduk AM, Murphy TE, Geda M, Krumholz HM, Tsang S, Nanna MG, Tinetti ME, Goldstein D, Forman DE, Alexander KP, Gill TM, Chaudhry SI. Thirty-Day Readmission Risk Model for Older Adults Hospitalized With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005320. PMID: 31010300, PMCID: PMC6481309, DOI: 10.1161/circoutcomes.118.005320.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overFemaleGeriatric AssessmentHealth Status IndicatorsHumansMaleMyocardial InfarctionPatient AdmissionPatient ReadmissionPredictive Value of TestsProspective StudiesReproducibility of ResultsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionReadmission risk modelFinal risk modelFunctional mobilityFunctional impairmentMyocardial infarctionOlder adultsFirst diastolic blood pressureChronic obstructive pulmonary diseaseAge-related functional impairmentsP2Y12 inhibitor useAcute kidney injuryDaily living (ADL) disabilityPatient-level factorsProspective cohort studyDiastolic blood pressureObstructive pulmonary diseasePatients of ageGeneral health statusStrongest predictorRisk modelMore comorbiditiesCause readmissionKidney injuryCohort study
2014
Design and rationale of the comprehensive evaluation of risk factors in older patients with AMI (SILVER-AMI) study
Dodson JA, Geda M, Krumholz HM, Lorenze N, Murphy TE, Allore HG, Charpentier P, Tsang SW, Acampora D, Tinetti ME, Gill TM, Chaudhry SI. Design and rationale of the comprehensive evaluation of risk factors in older patients with AMI (SILVER-AMI) study. BMC Health Services Research 2014, 14: 506. PMID: 25370536, PMCID: PMC4239317, DOI: 10.1186/s12913-014-0506-4.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth status declineOlder patientsRisk factorsGeriatric impairmentsHospital readmissionOlder adultsDetailed medical record abstractionStatus declineDiagnostic study resultsPost-AMI outcomesProportion of patientsProspective cohort studyMedical record abstractionAMI studyHealth status measuresClinical characteristicsCohort studyRecord abstractionAdverse outcomesMyocardial infarctionAcademic hospitalHospital assessmentMultivariable regressionStatus measures
2010
Racial Disparities in Health Literacy and Access to Care Among Patients With Heart Failure
Chaudhry SI, Herrin J, Phillips C, Butler J, Mukerjhee S, Murillo J, Onwuanyi A, Seto TB, Spertus J, Krumholz HM. Racial Disparities in Health Literacy and Access to Care Among Patients With Heart Failure. Journal Of Cardiac Failure 2010, 17: 122-127. PMID: 21300301, PMCID: PMC3053061, DOI: 10.1016/j.cardfail.2010.09.016.Peer-Reviewed Original ResearchConceptsHeart failure patientsHealth literacyFailure patientsHeart failureInsurance statusWorse health literacyOutpatient medical careRacial differencesImportant racial differencesNoncardiac comorbiditiesUnadjusted analysesBlack raceCare existMedical homePatientsMedical careRacial disparitiesSocioeconomic statusStrong associationPotential mediatorsHealth carePoor accessCareSocial supportStatus
2008
Systolic Function as a Predictor of Mortality and Quality of Life in Long‐term Survivors with Heart Failure
McNamara R, Austin B, Wang Y, Smith G, Vaccarine V, Krumholz H. Systolic Function as a Predictor of Mortality and Quality of Life in Long‐term Survivors with Heart Failure. Clinical Cardiology 2008, 31: 119-124. PMID: 18383045, PMCID: PMC6653267, DOI: 10.1002/clc.20118.Peer-Reviewed Original ResearchConceptsQuality of lifeEjection fractionHeart failureLong-term survivorsFunctional declineSystolic functionKansas City Cardiomyopathy Questionnaire scoreModest survival advantageReduced ejection fractionDaily living scoreDisease-related qualityPredictors of mortalityHeart failure patientsClinical summary scoreLong-term survivalHigh mortality rateKCCQ scoresRenal insufficiencyFailure patientsLiving scoreDiabetes mellitusOverall mortalityPrimary outcomeLimitation scoresQOL scoresThe Relationship Between Anemia, Change in Hematocrit Over Time and Change in Health Status in Patients With Heart Failure After Myocardial Infarction
Kosiborod M, Krumholz HM, Jones PG, Pitt B, Spertus JA. The Relationship Between Anemia, Change in Hematocrit Over Time and Change in Health Status in Patients With Heart Failure After Myocardial Infarction. Journal Of Cardiac Failure 2008, 14: 27-34. PMID: 18226770, DOI: 10.1016/j.cardfail.2007.09.009.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnemiaCohort StudiesFemaleHealth Status IndicatorsHeart FailureHeart Function TestsHematocritHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionProbabilityPrognosisQuality of LifeRisk AssessmentSickness Impact ProfileSurveys and QuestionnairesSurvival AnalysisTime FactorsConceptsKansas City Cardiomyopathy QuestionnaireHeart failureHealth status gainsHealth statusBaseline hematocritInitial hematocritMyocardial infarctionPatient’s initial hematocritPotential therapeutic targetHealth status assessmentMultivariable adjustmentAnemic patientsSevere anemiaSerial hematocritsHematocrit levelsPatientsTherapeutic targetHematocrit changesHematocritAnemiaInfarctionLinear regression modelsMonthsRegression modelsSignificant changes
2007
Identifying Heart Failure Patients at High Risk for Near-Term Cardiovascular Events With Serial Health Status Assessments
Kosiborod M, Soto GE, Jones PG, Krumholz HM, Weintraub WS, Deedwania P, Spertus JA. Identifying Heart Failure Patients at High Risk for Near-Term Cardiovascular Events With Serial Health Status Assessments. Circulation 2007, 115: 1975-1981. PMID: 17420346, DOI: 10.1161/circulationaha.106.670901.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireHeart failure outpatientsHealth status assessmentCause mortalityCardiovascular mortalityKaplan-Meier survival analysisHigh-risk patientsHeart failure patientsAcute myocardial infarctionProportional hazards modelIntensity of treatmentStatus assessmentKCCQ scoresCardiovascular deathCardiovascular eventsClinical deteriorationMultivariable adjustmentFailure patientsHeart failureOutpatient visitsMyocardial infarctionHigh riskHospitalizationPatientsCombined outcome
2005
The Relationship Between B-type Natriuretic Peptide and Health Status in Patients With Heart Failure
Luther SA, McCullough PA, Havranek EP, Rumsfeld JS, Jones PG, Heidenreich PA, Peterson ED, Rathore SS, Krumholz HM, Weintraub WS, Spertus JA, Masoudi FA, Consortium F. The Relationship Between B-type Natriuretic Peptide and Health Status in Patients With Heart Failure. Journal Of Cardiac Failure 2005, 11: 414-421. PMID: 16105631, DOI: 10.1016/j.cardfail.2005.02.004.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireBNP levelsHeart failureHealth statusBNP changesB-type natriuretic peptide levelsNew York Heart Association classificationB-type natriuretic peptideBaseline BNP levelsKCCQ summary scoreNatriuretic peptide levelsHeart failure severitySystolic heart failureHealth status instrumentsBaseline BNPKCCQ scoresNatriuretic peptideAssociation classificationPatients' perceptionsPeptide levelsPhysiologic measuresSummary scoresPatientsBNPDisease severity
2004
Prognostic Value of Health Status in Patients With Heart Failure After Acute Myocardial Infarction
Soto GE, Jones P, Weintraub WS, Krumholz HM, Spertus JA. Prognostic Value of Health Status in Patients With Heart Failure After Acute Myocardial Infarction. Circulation 2004, 110: 546-551. PMID: 15262843, DOI: 10.1161/01.cir.0000136991.85540.a9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmericasCardiovascular DiseasesCohort StudiesComorbidityDisease-Free SurvivalEplerenoneEuropeFemaleHealth Status IndicatorsHeart FailureHospitalizationHumansMaleMiddle AgedMineralocorticoid Receptor AntagonistsMyocardial InfarctionPrognosisProspective StudiesRisk FactorsSeverity of Illness IndexSpironolactoneConceptsKansas City Cardiomyopathy QuestionnaireAcute myocardial infarctionHeart failureKCCQ-OSMyocardial infarctionHealth statusKCCQ scoresCardiovascular mortalityPrognostic valueDisease-specific health status instrumentRecent acute myocardial infarctionSubsequent cardiovascular eventsEvent-free survivalOutpatient clinical practiceFirst outpatient visitHealth status instrumentsPatients' health statusQuality of lifeCardiovascular eventsClinical characteristicsOutpatient visitsMultivariable modelInternational cohortFunctional limitationsClinical practice
2003
Depressive symptoms are the strongest predictors of short-term declines in health status in patients with heart failure
Rumsfeld JS, Havranek E, Masoudi FA, Peterson ED, Jones P, Tooley JF, Krumholz HM, Spertus JA, Consortium C. Depressive symptoms are the strongest predictors of short-term declines in health status in patients with heart failure. Journal Of The American College Of Cardiology 2003, 42: 1811-1817. PMID: 14642693, DOI: 10.1016/j.jacc.2003.07.013.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireKCCQ summary scoreDepressive symptomsQuality of lifeHealth statusKCCQ scoresHeart failureDepressed patientsSummary scoresMulticenter prospective cohort studyStrongest predictorBaseline KCCQ scoresProspective cohort studySignificant depressive symptomsSpecific health statusTreatment of depressionShort-term worseningPredictors of changeHF careHF symptomsCohort studyPrimary outcomePotential confoundersPatient variablesMultivariable model
2000
Impact of Smoking on Health-Related Quality of Life After Percutaneous Coronary Revascularization
Taira D, Seto T, Ho K, Krumholz H, Cutlip D, Berezin R, Kuntz R, Cohen D. Impact of Smoking on Health-Related Quality of Life After Percutaneous Coronary Revascularization. Circulation 2000, 102: 1369-1374. PMID: 10993854, DOI: 10.1161/01.cir.102.12.1369.Peer-Reviewed Original ResearchConceptsGeneral health perceptionSmoking statusHealth perceptionMedical Outcomes Study SF-36 questionnaireSymptomatic coronary artery diseaseMental healthRole-physical functioningImpact of smokingLate myocardial infarctionHealth-related qualityPercutaneous coronary revascularizationSF-36 questionnaireCoronary artery diseaseMulticenter clinical trialTime of PTCAQuality of lifeHRQoL improvementContinued smokingCoronary revascularizationBaseline characteristicsArtery diseaseIndex procedureSmoking cessationPhysical functionMyocardial infarction
1997
Health after coronary stenting or balloon angioplasty: Results from the Stent Restenosis Study
Krumholz H, Cohen D, Williams C, Baim D, Brinker J, Cabin H, Heuser R, Hirshfeld J, Leon M, Moses J, Savage M, Cleman M. Health after coronary stenting or balloon angioplasty: Results from the Stent Restenosis Study. American Heart Journal 1997, 134: 337-344. PMID: 9327686, DOI: 10.1016/s0002-8703(97)70065-6.Peer-Reviewed Original ResearchConceptsStent Restenosis StudyCoronary stentingBalloon angioplastyRestenosis StudyDuke Activity Status IndexPalmaz-Schatz coronary stentingCanadian Cardiovascular Society classificationPalmaz-Schatz coronary stent implantationPercutaneous transluminal coronary angioplastyU.S. clinical sitesLong-term HRQoLForm Health SurveyHealth-related qualityMedical Outcomes StudyTransluminal coronary angioplastyCoronary stent implantationConventional balloon angioplastyDisease-specific measuresAngiographic restenosisConventional angioplastyIschemic eventsBodily painConsecutive patientsCoronary angioplastyCardiovascular perspective
1996
Aspirin for secondary prevention after acute myocardial infarction in the elderly: prescribed use and outcomes.
Krumholz HM, Radford MJ, Ellerbeck EF, Hennen J, Meehan TP, Petrillo M, Wang Y, Jencks SF. Aspirin for secondary prevention after acute myocardial infarction in the elderly: prescribed use and outcomes. Annals Of Internal Medicine 1996, 124: 292-8. PMID: 8554223, DOI: 10.7326/0003-4819-124-3-199602010-00002.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrescription of aspirinMyocardial infarctionPatient characteristicsPrescribed useMortality rate 6 monthsBetter overall health statusRate 6 monthsBeta-blocker therapyPatients 65 yearsUse of aspirinPatient demographic characteristicsAcute care hospitalsOverall health statusPrescribed aspirinDischarge medicationsElderly patientsHospital dischargeSecondary preventionCare hospitalClinical factorsMedical chartsMultivariable analysisCardiac proceduresTreatment characteristics