2017
Impact of Telemonitoring on Health Status
Jayaram NM, Khariton Y, Krumholz HM, Chaudhry SI, Mattera J, Tang F, Herrin J, Hodshon B, Spertus JA. Impact of Telemonitoring on Health Status. Circulation Cardiovascular Quality And Outcomes 2017, 10: e004148. PMID: 29237746, PMCID: PMC5776725, DOI: 10.1161/circoutcomes.117.004148.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireUsual careHealth statusHeart failureKCCQ overall summary scoreRecent heart failure hospitalizationDisease-specific health statusKCCQ overall summaryHeart failure hospitalizationWeeks of dischargeRandomized clinical trialsOverall summary scoreKCCQ scoresNoninvasive TelemonitoringFailure hospitalizationBaseline characteristicsSecondary outcomesTreatment armsClinical trialsSummary scoresPatientsSubscale scoresCareHospitalizationScoresSex Differences in Inflammatory Markers and Health Status Among Young Adults With Acute Myocardial Infarction
Lu Y, Zhou S, Dreyer RP, Spatz ES, Geda M, Lorenze NP, D'Onofrio G, Lichtman JH, Spertus JA, Ridker PM, Krumholz HM. Sex Differences in Inflammatory Markers and Health Status Among Young Adults With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2017, 10: e003470. PMID: 28228461, PMCID: PMC5459381, DOI: 10.1161/circoutcomes.116.003470.Peer-Reviewed Original ResearchMeSH Keywords1-Alkyl-2-acetylglycerophosphocholine EsteraseAdolescentAdultAge of OnsetBiomarkersChi-Square DistributionComorbidityC-Reactive ProteinFemaleHealth Status DisparitiesHumansInflammation MediatorsLinear ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionProspective StudiesRisk AssessmentRisk FactorsSex FactorsSocioeconomic FactorsUnited StatesUp-RegulationYoung AdultConceptsHigh-sensitivity C-reactive proteinAcute myocardial infarctionHigher inflammatory levelsInflammatory markersPoor health statusHealth statusYoung womenMyocardial infarctionInflammatory levelsTargeted anti-inflammatory treatmentsElevated inflammatory markersResidual cholesterol riskResidual inflammatory riskSex differencesAnti-inflammatory treatmentAnti-inflammatory therapyC-reactive proteinHigher mortality riskYoung menPhospholipase A2Years of ageCardiovascular outcomesMultivariable adjustmentPatient characteristicsSecondary prevention
2016
Sex differences in lipid profiles and treatment utilization among young adults with acute myocardial infarction: Results from the VIRGO study
Lu Y, Zhou S, Dreyer RP, Caulfield M, Spatz ES, Geda M, Lorenze NP, Herbert P, D'Onofrio G, Jackson EA, Lichtman JH, Bueno H, Spertus JA, Krumholz HM. Sex differences in lipid profiles and treatment utilization among young adults with acute myocardial infarction: Results from the VIRGO study. American Heart Journal 2016, 183: 74-84. PMID: 27979045, PMCID: PMC5459396, DOI: 10.1016/j.ahj.2016.09.012.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionLipid profileYoung womenLipoprotein cholesterolLipoprotein profileMyocardial infarctionTreatment utilizationLow-density lipoprotein cholesterolHigh-density lipoprotein cholesterolLow HDL cholesterol levelsYoung adultsHigh-intensity doseMajor lipid abnormalitiesSex differencesAdverse lipid profileFavorable lipoprotein profileHDL cholesterol ratioLower total cholesterolHDL cholesterol levelsHigher HDL cholesterolImportant risk factorHigher mortality riskMultivariate regression analysisVIRGO StudyCardiovascular outcomesSex Differences in Financial Barriers and the Relationship to Recovery After Acute Myocardial Infarction
Beckman AL, Bucholz EM, Zhang W, Xu X, Dreyer RP, Strait KM, Spertus JA, Krumholz HM, Spatz ES. Sex Differences in Financial Barriers and the Relationship to Recovery After Acute Myocardial Infarction. Journal Of The American Heart Association 2016, 5: e003923. PMID: 27742618, PMCID: PMC5121496, DOI: 10.1161/jaha.116.003923.Peer-Reviewed Original ResearchMeSH KeywordsAdultAftercareDepressionDrug CostsFemaleHealth Services AccessibilityHumansIncomeLinear ModelsMaleMedication AdherenceMiddle AgedMultivariate AnalysisMyocardial InfarctionPatient Health QuestionnaireProspective StudiesRecovery of FunctionSex FactorsSocioeconomic FactorsSpainUnited StatesConceptsAcute myocardial infarctionMyocardial infarctionFinancial barriersHealth status 12 monthsYoung adultsPost-AMI outcomesYear post-AMIYoung AMI patientsMultivariable linear regression modelsGreater depressive symptomatologyMental functional statusSex differencesClinical characteristicsYounger patientsAMI patientsPost-AMIFunctional statusWorse outcomesBaseline healthPsychosocial statusOutcomes 1Depressive symptomatologyPatientsMore womenHealth care
2014
Hospital Strategy Uptake and Reductions in Unplanned Readmission Rates for Patients with Heart Failure: A Prospective Study
Bradley EH, Sipsma H, Horwitz LI, Ndumele CD, Brewster AL, Curry LA, Krumholz HM. Hospital Strategy Uptake and Reductions in Unplanned Readmission Rates for Patients with Heart Failure: A Prospective Study. Journal Of General Internal Medicine 2014, 30: 605-611. PMID: 25523470, PMCID: PMC4395590, DOI: 10.1007/s11606-014-3105-5.Peer-Reviewed Original ResearchConceptsRisk-standardized readmission ratesUnplanned readmission rateUptake of strategiesReadmission ratesHeart failureProspective studyGreater reductionAvoidable Rehospitalizations (STAAR) initiativeSame time pointsFinal analytic sampleParticipantsThe studyMain MeasuresWeHospitalPatientsWeb-based surveyAnalytic sampleTime pointsBaselineHospital strategiesSignificant reductionOne-quarterMonthsMore strategiesNational sampleAssociation
2013
For-profit hospital ownership status and use of brachytherapy after breast-conserving surgery
Sen S, Soulos PR, Herrin J, Roberts KB, Yu JB, Lesnikoski BA, Ross JS, Krumholz HM, Gross CP. For-profit hospital ownership status and use of brachytherapy after breast-conserving surgery. Surgery 2013, 155: 776-788. PMID: 24787104, PMCID: PMC4008843, DOI: 10.1016/j.surg.2013.12.009.Peer-Reviewed Original ResearchConceptsHospital ownership statusBreast-conserving operationsBreast-conserving surgeryUse of brachytherapyRadiation therapyOperative careBreast cancerMedicare beneficiariesOverall useReceipt of brachytherapyAdjuvant radiation therapyInvasive breast cancerFemale Medicare beneficiariesGreater overall useYears of ageShort life expectancyRetrospective studyRT modalityProfit hospitalsExpensive modalityOlder womenBrachytherapy useBreast brachytherapyHospitalBrachytherapyHospital Strategies Associated With 30-Day Readmission Rates for Patients With Heart Failure
Bradley EH, Curry L, Horwitz LI, Sipsma H, Wang Y, Walsh MN, Goldmann D, White N, Piña IL, Krumholz HM. Hospital Strategies Associated With 30-Day Readmission Rates for Patients With Heart Failure. Circulation Cardiovascular Quality And Outcomes 2013, 6: 444-450. PMID: 23861483, PMCID: PMC3802532, DOI: 10.1161/circoutcomes.111.000101.Peer-Reviewed Original ResearchConceptsLower readmission ratesReadmission ratesHeart failurePrimary physicianHospital strategiesPatient's primary physicianHospital readmission ratesMultivariable linear regression modelsHospital teaching statusNational quality initiativesHospital volumeMedication reconciliationDischarge papersCommunity physiciansLocal hospitalPatientsWeb-based surveyReadmissionPhysician groupsTeaching statusHospitalElectronic summariesQuality InitiativePercentage point reductionLinear regression modelsHospital-Based, Acute Care Use Among Patients Within 30 Days of Discharge After Coronary Artery Bypass Surgery
Fox JP, Suter LG, Wang K, Wang Y, Krumholz HM, Ross JS. Hospital-Based, Acute Care Use Among Patients Within 30 Days of Discharge After Coronary Artery Bypass Surgery. The Annals Of Thoracic Surgery 2013, 96: 96-104. PMID: 23702228, PMCID: PMC3758868, DOI: 10.1016/j.athoracsur.2013.03.091.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCaliforniaCoronary Artery BypassCoronary Artery DiseaseEmergency Service, HospitalFemaleFollow-Up StudiesHumansIntensive Care UnitsLength of StayLinear ModelsMaleMiddle AgedMorbidityPatient DischargePatient ReadmissionPostoperative ComplicationsPostoperative PeriodPrognosisRecurrenceRetrospective StudiesRisk FactorsSurvival RateTime FactorsYoung AdultConceptsDays of dischargeAcute care needsCABG surgeryED visit ratesED visitsHospital readmissionReadmission ratesCare needsCoronary artery bypass graft surgeryVisit ratesArtery bypass graft surgeryCoronary artery bypass surgeryRisk-standardized readmission ratesAcute care ratesHospital 30 daysBypass graft surgeryAcute care useArtery bypass surgeryCongestive heart failureEmergency department visitsEmergency Department DatabasesChest discomfortGraft surgeryBypass surgeryHospital volumeRegional Density of Cardiologists and Rates of Mortality for Acute Myocardial Infarction and Heart Failure
Kulkarni VT, Ross JS, Wang Y, Nallamothu BK, Spertus JA, Normand SL, Masoudi FA, Krumholz HM. Regional Density of Cardiologists and Rates of Mortality for Acute Myocardial Infarction and Heart Failure. Circulation Cardiovascular Quality And Outcomes 2013, 6: 352-359. PMID: 23680965, PMCID: PMC5323047, DOI: 10.1161/circoutcomes.113.000214.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiologyCohort StudiesFemaleHealth Services AccessibilityHealth Services Needs and DemandHealthcare DisparitiesHeart FailureHospitalizationHumansLinear ModelsLogistic ModelsMaleMedicareMyocardial InfarctionOdds RatioPhysiciansPneumoniaPrognosisResidence CharacteristicsRisk AssessmentRisk FactorsTime FactorsUnited StatesWorkforceConceptsAcute myocardial infarctionHeart failureHospital referral regionsMortality riskLowest quintileMyocardial infarctionReferral regionsMedicare administrative claims dataCharacteristics of patientsRisk of deathAdministrative claims dataHierarchical logistic regression modelsLogistic regression modelsRate of mortalityRegional densityHighest quintileNumber of cardiologistsWorse outcomesClaims dataPatientsPneumoniaCardiologistsHospitalizationAdmissionQuintile
2012
Procedure Intensity and the Cost of Care
Chen SI, Dharmarajan K, Kim N, Strait KM, Li SX, Safavi KC, Lindenauer PK, Krumholz HM, Lagu T. Procedure Intensity and the Cost of Care. Circulation Cardiovascular Quality And Outcomes 2012, 5: 308-313. PMID: 22576844, PMCID: PMC3415230, DOI: 10.1161/circoutcomes.112.966069.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCosts and Cost AnalysisCross-Sectional StudiesFemaleHeart FailureHospital Bed CapacityHospital CostsHospital MortalityHospitalizationHospitals, RuralHospitals, TeachingHospitals, UrbanHumansLength of StayLinear ModelsMaleMiddle AgedModels, EconomicOutcome and Process Assessment, Health CareResidence CharacteristicsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsHF hospitalizationHeart failureInvasive proceduresHospital groupRisk-standardized mortality ratesProportion of patientsLength of stayCost of careWilcoxon rank sum testHigher procedure ratesRank sum testPatient demographicsPerspective databaseMedian lengthSurgical proceduresProcedure ratesHospitalizationOutcome differencesMortality rateHospitalPatientsPractice styleProcedure useSum testOverall useOutcomes for Mitral Valve Surgery Among Medicare Fee-for-Service Beneficiaries, 1999 to 2008
Dodson JA, Wang Y, Desai MM, Barreto-Filho JA, Sugeng L, Hashim SW, Krumholz HM. Outcomes for Mitral Valve Surgery Among Medicare Fee-for-Service Beneficiaries, 1999 to 2008. Circulation Cardiovascular Quality And Outcomes 2012, 5: 298-307. PMID: 22576847, PMCID: PMC3400109, DOI: 10.1161/circoutcomes.112.966077.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overChi-Square DistributionFee-for-Service PlansFemaleHealthcare DisparitiesHeart Valve DiseasesHeart Valve Prosthesis ImplantationHospital MortalityHospitalizationHumansLinear ModelsMaleMedicareMitral ValveOdds RatioPatient ReadmissionQuality ImprovementRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsMitral valve surgeryValve surgeryMitral valve repairFFS patientsHospitalization ratesValve repairMedicare feeMedicare Standard Analytic FilesMedicare FFS patientsRisk-standardized ratesProportion of patientsStandard Analytic FilesVital Status filesNational surveillance dataMedicare administrative dataSubstantial morbidityMortality outcomesService patientsAnalytic FilesMortality riskMortality rateSurgeryPatientsDenominator fileReadmission
2010
Patterns of moderate and vigorous physical activity in obese and overweight compared with non‐overweight children
DORSEY KB, HERRIN J, KRUMHOLZ HM. Patterns of moderate and vigorous physical activity in obese and overweight compared with non‐overweight children. Pediatric Obesity 2010, 6: e547-e555. PMID: 20883127, PMCID: PMC3815589, DOI: 10.3109/17477166.2010.490586.Peer-Reviewed Original ResearchConceptsVigorous physical activityOW/OBNon-overweight childrenMVPA boutsPhysical activityGreater body mass index z-scoreVPA boutsOW/OB groupBody mass index z-scoreMean daily MVPANon-overweight groupLess physical activityIndex z-scoreMinutes of MVPANon-overweight peersObese childrenObese participantsOverweight childrenOB groupDaily MVPASustained MVPADistinct patternsOB participantsMVPAConsecutive boutsUse of Administrative Claims Models to Assess 30-Day Mortality Among Veterans Health Administration Hospitals
Ross JS, Maynard C, Krumholz HM, Sun H, Rumsfeld JS, Normand SL, Wang Y, Fihn SD. Use of Administrative Claims Models to Assess 30-Day Mortality Among Veterans Health Administration Hospitals. Medical Care 2010, 48: 652-658. PMID: 20548253, PMCID: PMC3020977, DOI: 10.1097/mlr.0b013e3181dbe35d.Peer-Reviewed Original ResearchConceptsStatistical modelAcute myocardial infarctionVeterans Health Administration hospitalsVHA hospitalsHeart failurePneumonia hospitalizationsC-statisticNon-federal hospitalsMedian numberModest heterogeneityAdministration HospitalAdministrative claims dataService Medicare beneficiariesYears of ageThirty-Day Outcomes in Medicare Patients With Heart Failure at Heart Transplant Centers
Hummel SL, Pauli NP, Krumholz HM, Wang Y, Chen J, Normand SL, Nallamothu BK. Thirty-Day Outcomes in Medicare Patients With Heart Failure at Heart Transplant Centers. Circulation Heart Failure 2010, 3: 244-252. PMID: 20061519, DOI: 10.1161/circheartfailure.109.884098.Peer-Reviewed Original ResearchConceptsHeart transplant centersRisk-standardized readmission ratesRisk-standardized mortality ratesTransplant centersStandardized mortality ratioHeart failureTransplant hospitalsReadmission ratesMortality rateStandardized readmission ratioMortality ratioMedicare patientsReadmission ratiosMean standardized mortality ratioThirty-day outcomesCoronary artery bypassHeart failure careElderly Medicare patientsElderly Medicare beneficiariesArtery bypassElderly patientsTransplant candidatesMedicare beneficiariesHospitalPatients
2008
The Relationship Between Anemia, Change in Hematocrit Over Time and Change in Health Status in Patients With Heart Failure After Myocardial Infarction
Kosiborod M, Krumholz HM, Jones PG, Pitt B, Spertus JA. The Relationship Between Anemia, Change in Hematocrit Over Time and Change in Health Status in Patients With Heart Failure After Myocardial Infarction. Journal Of Cardiac Failure 2008, 14: 27-34. PMID: 18226770, DOI: 10.1016/j.cardfail.2007.09.009.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnemiaCohort StudiesFemaleHealth Status IndicatorsHeart FailureHeart Function TestsHematocritHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionProbabilityPrognosisQuality of LifeRisk AssessmentSickness Impact ProfileSurveys and QuestionnairesSurvival AnalysisTime FactorsConceptsKansas City Cardiomyopathy QuestionnaireHeart failureHealth status gainsHealth statusBaseline hematocritInitial hematocritMyocardial infarctionPatient’s initial hematocritPotential therapeutic targetHealth status assessmentMultivariable adjustmentAnemic patientsSevere anemiaSerial hematocritsHematocrit levelsPatientsTherapeutic targetHematocrit changesHematocritAnemiaInfarctionLinear regression modelsMonthsRegression modelsSignificant changes
2007
Predictors of weight change in overweight patients with myocardial infarction
Fadl YY, Krumholz HM, Kosiborod M, Masoudi FA, Peterson PN, Reid KJ, Weintraub WS, Buchanan DM, Spertus JA. Predictors of weight change in overweight patients with myocardial infarction. American Heart Journal 2007, 154: 711-717. PMID: 17892997, DOI: 10.1016/j.ahj.2007.06.006.Peer-Reviewed Original ResearchConceptsPost-MI patientsMyocardial infarctionOverweight patientsWeight changeWeight lossDepression 1 monthMean weight changePercent weight changeMultivariable linear regressionBaseline obesityOverweight survivorsMorbid obesityObese patientsProspective cohortMultivariable analysisIndependent correlatesWeight managementLifestyle characteristicsPatientsMean increasePREMIER studyHealth insuranceMonthsOverweightInfarctionOpening of Specialty Cardiac Hospitals and Use of Coronary Revascularization in Medicare Beneficiaries
Nallamothu BK, Rogers MA, Chernew ME, Krumholz HM, Eagle KA, Birkmeyer JD. Opening of Specialty Cardiac Hospitals and Use of Coronary Revascularization in Medicare Beneficiaries. JAMA 2007, 297: 962-968. PMID: 17341710, DOI: 10.1001/jama.297.9.962.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCardiac Care FacilitiesCardiology Service, HospitalCatchment Area, HealthCoronary Artery BypassHealth Care SurveysHealth Services Needs and DemandHospitals, GeneralHumansLinear ModelsMedicareMyocardial RevascularizationPractice Patterns, Physicians'Program DevelopmentReimbursement, IncentiveUnited StatesUtilization ReviewConceptsHospital referral regionsPopulation-based ratesSpecialty cardiac hospitalsCardiac hospitalTotal revascularizationCoronary revascularizationGeneral HospitalMedicare beneficiariesCardiac programAnnual population-based ratesAcute myocardial infarctionCost-efficient careMyocardial infarctionAdjusted ratesRevascularizationReferral regionsProcedure utilizationHospitalCABGPCIPatientsLinear regression modelsRegression modelsRelative increaseHealth care market
2006
Strategies for Reducing the Door-to-Balloon Time in Acute Myocardial Infarction
Bradley EH, Herrin J, Wang Y, Barton BA, Webster TR, Mattera JA, Roumanis SA, Curtis JP, Nallamothu BK, Magid DJ, McNamara RL, Parkosewich J, Loeb JM, Krumholz HM. Strategies for Reducing the Door-to-Balloon Time in Acute Myocardial Infarction. New England Journal Of Medicine 2006, 355: 2308-2320. PMID: 17101617, DOI: 10.1056/nejmsa063117.Peer-Reviewed Original ResearchConceptsST-segment elevationBalloon timeCatheterization laboratoryMyocardial infarctionFaster doorEmergency departmentPrimary percutaneous coronary interventionHospital strategiesIntracoronary balloon inflationPercutaneous coronary interventionAcute myocardial infarctionMinority of hospitalsEmergency medicine physiciansReperfusion treatmentCoronary interventionBalloon inflationMedicine physiciansMultivariate analysisHospitalInfarctionPatientsMedicaid ServicesSignificant reductionReal-time data feedbackData feedback
2004
Age, functional capacity, and health-related quality of life in patients with heart failure
Masoudi FA, Rumsfeld JS, Havranek EP, House JA, Peterson ED, Krumholz HM, Spertus JA, Consortium F. Age, functional capacity, and health-related quality of life in patients with heart failure. Journal Of Cardiac Failure 2004, 10: 368-373. PMID: 15470645, DOI: 10.1016/j.cardfail.2004.01.009.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireHealth-related qualityHeart failureYounger patientsFunctional statusNYHA classOlder patientsBetter HRQLFunctional limitationsWalk distanceNew York Heart Association classificationMulticenter prospective cohort studyOlder personsBaseline NYHA classWorse NYHA classProspective cohort studySignificant functional limitationsBaseline functional limitationsSignificant physical disabilityImportance of treatmentBaseline HRQLMultivariable adjustmentCohort studyAssociation classificationHRQL
2000
Impact of Smoking on Health-Related Quality of Life After Percutaneous Coronary Revascularization
Taira D, Seto T, Ho K, Krumholz H, Cutlip D, Berezin R, Kuntz R, Cohen D. Impact of Smoking on Health-Related Quality of Life After Percutaneous Coronary Revascularization. Circulation 2000, 102: 1369-1374. PMID: 10993854, DOI: 10.1161/01.cir.102.12.1369.Peer-Reviewed Original ResearchConceptsGeneral health perceptionSmoking statusHealth perceptionMedical Outcomes Study SF-36 questionnaireSymptomatic coronary artery diseaseMental healthRole-physical functioningImpact of smokingLate myocardial infarctionHealth-related qualityPercutaneous coronary revascularizationSF-36 questionnaireCoronary artery diseaseMulticenter clinical trialTime of PTCAQuality of lifeHRQoL improvementContinued smokingCoronary revascularizationBaseline characteristicsArtery diseaseIndex procedureSmoking cessationPhysical functionMyocardial infarction