2024
Natural Language Processing of Clinical Documentation to Assess Functional Status in Patients With Heart Failure
Adejumo P, Thangaraj P, Dhingra L, Aminorroaya A, Zhou X, Brandt C, Xu H, Krumholz H, Khera R. Natural Language Processing of Clinical Documentation to Assess Functional Status in Patients With Heart Failure. JAMA Network Open 2024, 7: e2443925. PMID: 39509128, PMCID: PMC11544492, DOI: 10.1001/jamanetworkopen.2024.43925.Peer-Reviewed Original ResearchConceptsFunctional status assessmentArea under the receiver operating characteristic curveClinical documentationElectronic health record dataHF symptomsOptimal care deliveryHealth record dataAssess functional statusStatus assessmentClinical trial participationProcessing of clinical documentsFunctional status groupCare deliveryOutpatient careMain OutcomesMedical notesTrial participantsNew York Heart AssociationFunctional statusQuality improvementRecord dataHeart failureClinical notesDiagnostic studiesStatus groups
2020
Evaluation of a Risk Stratification Model Using Preoperative and Intraoperative Data for Major Morbidity or Mortality After Cardiac Surgical Treatment
Durant TJS, Jean RA, Huang C, Coppi A, Schulz WL, Geirsson A, Krumholz HM. Evaluation of a Risk Stratification Model Using Preoperative and Intraoperative Data for Major Morbidity or Mortality After Cardiac Surgical Treatment. JAMA Network Open 2020, 3: e2028361. PMID: 33284333, DOI: 10.1001/jamanetworkopen.2020.28361.Peer-Reviewed Original ResearchPerformance of Temporal Artery Temperature Measurement in Ruling Out Fever: Implications for COVID-19 Screening
Haimovich AD, Taylor RA, Krumholz HM, Venkatesh AK. Performance of Temporal Artery Temperature Measurement in Ruling Out Fever: Implications for COVID-19 Screening. Journal Of General Internal Medicine 2020, 35: 3398-3400. PMID: 32930937, PMCID: PMC7491363, DOI: 10.1007/s11606-020-06205-2.Peer-Reviewed Original Research
2019
Machine Learning Prediction of Mortality and Hospitalization in Heart Failure With Preserved Ejection Fraction
Angraal S, Mortazavi BJ, Gupta A, Khera R, Ahmad T, Desai NR, Jacoby DL, Masoudi FA, Spertus JA, Krumholz HM. Machine Learning Prediction of Mortality and Hospitalization in Heart Failure With Preserved Ejection Fraction. JACC Heart Failure 2019, 8: 12-21. PMID: 31606361, DOI: 10.1016/j.jchf.2019.06.013.Peer-Reviewed Original ResearchConceptsHF hospitalizationRisk of mortalityEjection fractionBlood urea nitrogen levelsLogistic regressionPrevious HF hospitalizationHeart failure hospitalizationReduced ejection fractionReceiver-operating characteristic curveRisk of deathBody mass indexBlood urea nitrogenUrea nitrogen levelsHealth status dataMean c-statisticKCCQ scoresTOPCAT trialFailure hospitalizationHeart failureHemoglobin levelsMass indexC-statisticHospitalizationUrea nitrogenMortality
2006
Prediction of medical morbidity and mortality after acute myocardial infarction in patients at increased psychosocial risk in the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) study
Jaffe AS, Krumholz HM, Catellier DJ, Freedland KE, Bittner V, Blumenthal JA, Calvin JE, Norman J, Sequeira R, O'Connor C, Rich MW, Sheps D, Wu C, Investigators F. Prediction of medical morbidity and mortality after acute myocardial infarction in patients at increased psychosocial risk in the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) study. American Heart Journal 2006, 152: 126-135. PMID: 16824842, DOI: 10.1016/j.ahj.2005.10.004.Peer-Reviewed Original ResearchConceptsPost-MI patientsAcute myocardial infarctionMyocardial infarctionLow social supportCardiovascular mortalityEnd pointNonfatal myocardial infarctionPrimary end pointSecondary end pointsLong-term mortalityPrior myocardial infarctionSignificant multivariable predictorsProportional hazards modelSocial supportKillip classCause mortalityElevated creatinineRecurrent infarctionAdverse eventsBaseline characteristicsBypass surgeryEjection fractionHeart failureMedical morbidityMedical predictors
2002
The prognostic importance of different definitions of worsening renal function in congestive heart failure
Gottlieb SS, Abraham W, Butler J, Forman DE, Loh E, Massie BM, O'Connor CM, Rich MW, Stevenson LW, Young J, Krumholz HM. The prognostic importance of different definitions of worsening renal function in congestive heart failure. Journal Of Cardiac Failure 2002, 8: 136-141. PMID: 12140805, DOI: 10.1054/jcaf.2002.125289.Peer-Reviewed Original ResearchConceptsCongestive heart failureRenal functionLength of stayHeart failurePrognostic importanceDepressed ejection fractionProlonged hospital stayFinal creatinineHospital mortalityHospital stayRenal failureSerum creatinineDL increaseEjection fractionACE inhibitorsPoor prognosisPatient populationWorse outcomesPrior historyTherapeutic interventionsCreatinineStayPatientsMortalityDl
1999
Early beta-blocker therapy for acute myocardial infarction in elderly patients.
Krumholz H, Radford M, Wang Y, Chen J, Marciniak T. Early beta-blocker therapy for acute myocardial infarction in elderly patients. Annals Of Internal Medicine 1999, 131: 648-54. PMID: 10577326, DOI: 10.7326/0003-4819-131-9-199911020-00003.Peer-Reviewed Original ResearchConceptsEarly beta-blocker therapyBeta-blocker therapyAcute myocardial infarctionMyocardial infarctionElderly patientsEarly useHospital mortality ratePatients 65 yearsMedical chart reviewAcute care hospitalsYears of ageHospital mortalityHospital deathChart reviewPatient demographicsCare hospitalClinical factorsTreatment characteristicsEarly treatmentBaseline differencesObservational studyHigh riskMedicare beneficiariesMortality ratePatients
1997
Thrombolytic Therapy for Eligible Elderly Patients With Acute Myocardial Infarction
Krumholz HM, Murillo JE, Chen J, Vaccarino V, Radford MJ, Ellerbeck EF, Wang Y. Thrombolytic Therapy for Eligible Elderly Patients With Acute Myocardial Infarction. JAMA 1997, 277: 1683-1688. PMID: 9169894, DOI: 10.1001/jama.1997.03540450039032.Peer-Reviewed Original ResearchConceptsST-segment elevationAcute myocardial infarctionThrombolytic therapyBundle branch blockMyocardial infarctionChest painElderly patientsMental statusBranch blockTotal ST-segment elevationEligible elderly patientsThrombolytic therapy useRetrospective cohort studyHours of symptomsOnset of symptomsPopulation-based sampleLack of treatmentDirect angioplastyEligible patientsAbsolute contraindicationBypass surgeryCohort studyMedical chartsTherapy useContiguous leads