2024
Sex differences in treatment strategies for pulmonary embolism in older adults: The SERIOUS-PE study of RIETE participants and US Medicare beneficiaries.
Bikdeli B, Leyva H, Muriel A, Lin Z, Piazza G, Khairani C, Rosovsky R, Mehdipour G, O'Donoghue M, Madridano O, Lopez-Saez J, Mellado M, Diaz Brasero A, Grandone E, Spagnolo P, Lu Y, Bertoletti L, López-Jiménez L, Jesús Núñez M, Blanco-Molina Á, Gerhard-Herman M, Goldhaber S, Bates S, Jimenez D, Krumholz H, Monreal M. Sex differences in treatment strategies for pulmonary embolism in older adults: The SERIOUS-PE study of RIETE participants and US Medicare beneficiaries. Vascular Medicine 2024, 1358863x241292023. PMID: 39588564, DOI: 10.1177/1358863x241292023.Peer-Reviewed Original ResearchRegistro Informatizado Enfermedad TromboEmbolicaIntermediate-risk PEInferior vena cavaPulmonary embolismFibrinolytic therapyAdvanced therapiesInferior vena cava filter placementUS Medicare beneficiariesSex differencesOlder adultsMedicare beneficiariesAnticoagulation patternsFilter placementVena cavaMale patientsClinical outcomesTreatment strategiesAssess sex differencesPE therapyTherapyRisk factorsStandardized differenceAnticoagulationTherapy utilizationSex disparities
2021
Clinician Trends in Prescribing Direct Oral Anticoagulants for US Medicare Beneficiaries
Wheelock KM, Ross JS, Murugiah K, Lin Z, Krumholz HM, Khera R. Clinician Trends in Prescribing Direct Oral Anticoagulants for US Medicare Beneficiaries. JAMA Network Open 2021, 4: e2137288. PMID: 34870678, PMCID: PMC8649845, DOI: 10.1001/jamanetworkopen.2021.37288.Peer-Reviewed Original ResearchConceptsDOAC useAnticoagulant prescriptionOral anticoagulantsUS cliniciansMedicare beneficiariesNational clinical practice guidelinesElevated bleeding riskOral anticoagulant prescriptionsRetrospective cohort studyDirect oral anticoagulantsClinical practice guidelinesUS Medicare beneficiariesInternal medicine physiciansNumber of cliniciansAnticoagulant prescribingDOAC prescriptionsUnique cliniciansBleeding riskCohort studyAnticoagulant strategiesPrescription claimsPractice guidelinesMAIN OUTCOMEMost indicationsMedicare populationPatterns of Prescribing Sodium-Glucose Cotransporter-2 Inhibitors for Medicare Beneficiaries in the United States
Sangha V, Lipska K, Lin Z, Inzucchi SE, McGuire DK, Krumholz HM, Khera R. Patterns of Prescribing Sodium-Glucose Cotransporter-2 Inhibitors for Medicare Beneficiaries in the United States. Circulation Cardiovascular Quality And Outcomes 2021, 14: e008381. PMID: 34779654, PMCID: PMC9022137, DOI: 10.1161/circoutcomes.121.008381.Peer-Reviewed Original ResearchConceptsType 2 diabetesMedicare beneficiariesSodium-glucose cotransporter 2 inhibitorsLarge randomized clinical trialsMedicare Part D prescriber dataChronic kidney diseaseCotransporter 2 inhibitorsAtherosclerotic cardiovascular diseasePercent of cliniciansRandomized clinical trialsUS Medicare beneficiariesAdvanced practice providersCross-sectional studyKidney outcomesSGLT2i useSulfonylurea prescriptionUnique cliniciansCardiovascular deathMedication classesKidney diseaseLabel indicationsClinical trialsSGLT2iCardiovascular diseasePractice providers
2005
Quality of Care and Outcomes of Older Patients With Heart Failure Hospitalized in the United States and Canada
Ko DT, Tu JV, Masoudi FA, Wang Y, Havranek EP, Rathore SS, Newman AM, Donovan LR, Lee DS, Foody JM, Krumholz HM. Quality of Care and Outcomes of Older Patients With Heart Failure Hospitalized in the United States and Canada. JAMA Internal Medicine 2005, 165: 2486-2492. PMID: 16314545, DOI: 10.1001/archinte.165.21.2486.Peer-Reviewed Original ResearchConceptsHeart failureProcess of careRisk-standardized mortalityQuality of careUS patientsMortality rateEnzyme inhibitorsLower crude mortality rateLower short-term mortalityAngiotensin-converting enzyme inhibitorRisk-standardized mortality ratesVentricular ejection fraction assessmentOutcomes of patientsShort-term mortalityUS Medicare beneficiariesIndividuals 65 yearsCrude mortality rateEjection fraction assessmentLow-risk characteristicsHealth care expendituresOlder patientsCanadian patientsCommon causeMedicare beneficiariesPatients