2024
Sex differences in treatment strategies for pulmonary embolism in older adults: The SERIOUS-PE study of RIETE participants and US Medicare beneficiaries.
Bikdeli B, Leyva H, Muriel A, Lin Z, Piazza G, Khairani C, Rosovsky R, Mehdipour G, O'Donoghue M, Madridano O, Lopez-Saez J, Mellado M, Diaz Brasero A, Grandone E, Spagnolo P, Lu Y, Bertoletti L, López-Jiménez L, Jesús Núñez M, Blanco-Molina Á, Gerhard-Herman M, Goldhaber S, Bates S, Jimenez D, Krumholz H, Monreal M. Sex differences in treatment strategies for pulmonary embolism in older adults: The SERIOUS-PE study of RIETE participants and US Medicare beneficiaries. Vascular Medicine 2024, 1358863x241292023. PMID: 39588564, DOI: 10.1177/1358863x241292023.Peer-Reviewed Original ResearchRegistro Informatizado Enfermedad TromboEmbolicaIntermediate-risk PEInferior vena cavaPulmonary embolismFibrinolytic therapyAdvanced therapiesInferior vena cava filter placementUS Medicare beneficiariesSex differencesOlder adultsMedicare beneficiariesAnticoagulation patternsFilter placementVena cavaMale patientsClinical outcomesTreatment strategiesAssess sex differencesPE therapyTherapyRisk factorsStandardized differenceAnticoagulationTherapy utilizationSex disparities
2021
Effectiveness of an impedance cardiography guided treatment strategy to improve blood pressure control in a real-world setting: results from a pragmatic clinical trial
Wang L, Lu Y, Wang H, Gu J, J Z, Lian Z, Zhang Z, Krumholz H, Sun N. Effectiveness of an impedance cardiography guided treatment strategy to improve blood pressure control in a real-world setting: results from a pragmatic clinical trial. Open Heart 2021, 8: e001719. PMID: 34580169, PMCID: PMC8477318, DOI: 10.1136/openhrt-2021-001719.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntihypertensive AgentsBlood PressureCardiography, ImpedanceChinaClinical Decision-MakingFemaleFollow-Up StudiesHumansHypertensionIncidenceMaleMiddle AgedPractice Guidelines as TopicRetrospective StudiesTherapy, Computer-AssistedTime FactorsTreatment OutcomeYoung AdultConceptsBody mass indexPeking University People's HospitalStandard care groupBlood pressure controlSystolic BPHaemodynamic groupsTreatment strategiesImpedance cardiographyBaseline BPBP goalHypertension clinicHaemodynamic profileBP levelsCare groupPeople's HospitalMean baseline systolic BPPressure controlReal-world clinical practiceBaseline systolic BPMean systolic BPDiastolic BP levelsProportion of patientsPragmatic clinical trialsReal-world populationBaseline DBP
2019
Application of the VIRGO taxonomy to differentiate acute myocardial infarction in young women
Sciria CT, Dreyer RP, D'Onofrio G, Safdar B, Krumholz HM, Spatz ES. Application of the VIRGO taxonomy to differentiate acute myocardial infarction in young women. International Journal Of Cardiology 2019, 288: 5-11. PMID: 31031078, DOI: 10.1016/j.ijcard.2019.03.054.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseCardiac catheterizationYoung womenNon-obstructive coronary artery diseaseSingle-center retrospective chart reviewYoung AMI Patients (VIRGO) studyObstructive coronary artery diseaseRetrospective chart reviewAcute myocardial infarctionProportion of womenUniversal definitionIndex admissionChart reviewArtery diseaseConsecutive womenMyocardial infarctionTreatment strategiesCatheterizationMore young womenType 2Type 1Class IType 4BWomenPatient studies
2016
The China Patient-Centred Evaluative Assessment of Cardiac Events (China PEACE)-Prospective Study of 3-Vessel Disease: rationale and design
Rao C, Bongiovanni T, Li X, Gao H, Zhang H, Li J, Zhao Y, Yuan X, Hua K, Hu S, Krumholz HM, Jiang L, Zheng Z. The China Patient-Centred Evaluative Assessment of Cardiac Events (China PEACE)-Prospective Study of 3-Vessel Disease: rationale and design. BMJ Open 2016, 6: e009743. PMID: 26880670, PMCID: PMC4762131, DOI: 10.1136/bmjopen-2015-009743.Peer-Reviewed Original ResearchConceptsComplex coronary artery diseaseCoronary artery diseaseArtery diseaseLarge cardiovascular centresCardiac eventsProspective studyCardiovascular CenterTreatment strategiesCoronary revascularisation proceduresSYNTAX score calculationThree-vessel diseaseElective coronary angiographyMedical record abstractionPatient-reported outcomesAppropriateness of treatmentQuality improvement initiativesQuality of lifeEligible patientsRevascularisation proceduresAdverse eventsGuideline adherenceHospital factorsProspective cohortSecondary preventionCoronary angiography
2003
Quality of Care of Medicare Beneficiaries with Acute Myocardial Infarction: Who Is Included in Quality Improvement Measurement?
Rathore SS, Wang Y, Radford MJ, Ordin DL, Krumholz HM. Quality of Care of Medicare Beneficiaries with Acute Myocardial Infarction: Who Is Included in Quality Improvement Measurement? Journal Of The American Geriatrics Society 2003, 51: 466-475. PMID: 12657065, DOI: 10.1046/j.1532-5415.2003.51154.x.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionReperfusion therapyOlder patientsMyocardial infarctionU.S. acute care hospitalsProportion of patientsAcute care hospitalsEffective treatment strategiesMedical record databaseOlder age groupsQuality of careQuality improvement measurementAdmission therapyDischarge therapyCare hospitalACE inhibitorsMedicare patientsTreatment strategiesRetrospective analysisMedicare beneficiariesPatientsEnzyme inhibitorsRecord databaseAge groupsTherapy
2002
The Cost-Effectiveness of Treatment for Varicocele Related Infertility
PENSON DF, PALTIEL AD, KRUMHOLZ HM, PALTER S. The Cost-Effectiveness of Treatment for Varicocele Related Infertility. Journal Of Urology 2002, 168: 2490-2494. PMID: 12441947, DOI: 10.1016/s0022-5347(05)64175-4.Peer-Reviewed Original ResearchConceptsImmediate IVFHealth care payorsRelated infertilityIntrauterine inseminationTreatment strategiesLive deliveryMain outcome measuresNumber of newbornsAdditional birthsCost-effectiveness analysisInfertile patientsImproved outcomesOutcome measuresPatient's perspectiveSurgical varicocelectomyIVFIncremental costInfertilityPatientsTreatmentPreferred approachBirthPayorsDeliveryVaricocelectomyThe Cost-Effectiveness of Treatment for Varicocele Related Infertility
PENSON D, PALTIEL A, KRUMHOLZ H, PALTER S. The Cost-Effectiveness of Treatment for Varicocele Related Infertility. Journal Of Urology 2002, 168: 2490-2494. DOI: 10.1097/00005392-200212000-00033.Peer-Reviewed Original ResearchImmediate IVFHealth care payorsRelated infertilityIntrauterine inseminationTreatment strategiesLive deliveryMain outcome measuresNumber of newbornsAdditional birthsCost-effectiveness analysisInfertile patientsImproved outcomesOutcome measuresPatient's perspectiveSurgical varicocelectomyAbstract PurposeIVFIncremental costInfertilityPatientsTreatmentPreferred approachBirthPayorsDeliveryCardiogenic shock complicating acute myocardial infarction in elderly patients: Does admission to a tertiary center improve survival?
Berger AK, Radford MJ, Krumholz HM. Cardiogenic shock complicating acute myocardial infarction in elderly patients: Does admission to a tertiary center improve survival? American Heart Journal 2002, 143: 768-776. PMID: 12040336, DOI: 10.1067/mhj.2002.122289.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCardiogenic shockMyocardial infarctionRevascularization servicesCoronary revascularizationPrognosis of patientsCommunity-based cohortCooperative Cardiovascular Project databaseCardiovascular resourcesEarly revascularizationIndex hospitalizationClinical characteristicsElderly patientsCoronary angioplastyTertiary centerBetter prognosisRevascularization capabilityInvasive strategyClinical trialsTreatment strategiesSurgery facilitiesInfarctionPatientsHospitalEarly benefits