2021
Mortality From Drug Overdoses, Homicides, Unintentional Injuries, Motor Vehicle Crashes, and Suicides During the Pandemic, March-August 2020
Faust JS, Du C, Mayes KD, Li SX, Lin Z, Barnett ML, Krumholz HM. Mortality From Drug Overdoses, Homicides, Unintentional Injuries, Motor Vehicle Crashes, and Suicides During the Pandemic, March-August 2020. JAMA 2021, 326: 84-86. PMID: 34019096, PMCID: PMC8140390, DOI: 10.1001/jama.2021.8012.Peer-Reviewed Original Research
2020
Newly diagnosed diabetes and outcomes after acute myocardial infarction in young adults
Ding Q, Spatz ES, Lipska KJ, Lin H, Spertus JA, Dreyer RP, Whittemore R, Funk M, Bueno H, Krumholz HM. Newly diagnosed diabetes and outcomes after acute myocardial infarction in young adults. Heart 2020, 107: 657-666. PMID: 33082173, PMCID: PMC8005796, DOI: 10.1136/heartjnl-2020-317101.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth statusDischarge diagnosisPharmacological treatmentMyocardial infarctionShort-term health statusYoung AMI Patients (VIRGO) studyDisease-specific health statusYoung adultsQuality of lifeHospital complicationsHospital mortalityMedication initiationBaseline characteristicsClinical outcomesDiabetesPatientsDiagnosisPatient studiesMonthsComplicationsInfarctionSignificant differencesOutcomesMortalityLeveraging the Electronic Health Records for Population Health: A Case Study of Patients With Markedly Elevated Blood Pressure
Lu Y, Huang C, Mahajan S, Schulz WL, Nasir K, Spatz ES, Krumholz HM. Leveraging the Electronic Health Records for Population Health: A Case Study of Patients With Markedly Elevated Blood Pressure. Journal Of The American Heart Association 2020, 9: e015033. PMID: 32200730, PMCID: PMC7428633, DOI: 10.1161/jaha.119.015033.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureSystolic blood pressureElevated blood pressureBlood pressureElectronic health recordsPopulation health surveillanceHealth recordsYale New Haven Health SystemHealth surveillanceHealth systemPatterns of patientsLarge health systemUsual careOutpatient encountersControl ratePatientsCare patternsPopulation healthMonthsHgSurveillancePrevalenceRecordsVisitsCare
2018
Factors Associated With Return to Work After Acute Myocardial Infarction in China
Jiang Z, Dreyer RP, Spertus JA, Masoudi FA, Li J, Zheng X, Li X, Wu C, Bai X, Hu S, Wang Y, Krumholz HM, Chen H. Factors Associated With Return to Work After Acute Myocardial Infarction in China. JAMA Network Open 2018, 1: e184831. PMID: 30646375, PMCID: PMC6324382, DOI: 10.1001/jamanetworkopen.2018.4831.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionIndex acute myocardial infarctionHistory of smokingMyocardial infarctionHospital complicationsBaseline characteristicsFemale sexPatient baseline characteristicsProspective cohort studyLower likelihoodAcute myocardial infarction hospitalizationsLogistic regression modelsMyocardial infarction hospitalizationsCohort studyPatient factorsChina PatientProspective studyChinese patientsMAIN OUTCOMEInfarctionPatientsMonthsHospitalizationComplicationsSmoking
2017
Heterogeneity in Early Responses in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial)
Dhruva SS, Huang C, Spatz ES, Coppi AC, Warner F, Li SX, Lin H, Xu X, Furberg CD, Davis BR, Pressel SL, Coifman RR, Krumholz HM. Heterogeneity in Early Responses in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). Hypertension 2017, 70: 94-102. PMID: 28559399, DOI: 10.1161/hypertensionaha.117.09221.Peer-Reviewed Original ResearchConceptsAntihypertensive therapySystolic blood pressure responseAdverse cardiovascular eventsFavorable initial responseBlood pressure responseHigher hazard ratioCardiovascular eventsCardiovascular outcomesHazard ratioMultivariable adjustmentHeart failureAverage SBPRandomized trialsOdds ratioCardiovascular diseaseSBPStudy participantsRespondersMonthsPressure responseImmediate respondersALLHATEarly responseInitial responseSuperior discriminationPerceived Stress After Acute Myocardial Infarction
Xu X, Bao H, Strait KM, Edmondson DE, Davidson KW, Beltrame JF, Bueno H, Lin H, Dreyer RP, Brush JE, Spertus JA, Lichtman JH, D'Onofrio G, Krumholz HM. Perceived Stress After Acute Myocardial Infarction. Psychosomatic Medicine 2017, 79: 50-58. PMID: 27984507, PMCID: PMC5459399, DOI: 10.1097/psy.0000000000000429.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPSS-14 scoreMiddle-aged patientsPatient characteristicsMyocardial infarctionSex differencesMonths of recoveryAMI anginaInitial hospitalizationPerceived Stress ScalePatientsAnginaLess improvementLinear mixed-effects modelsFirst monthPsychological stressMixed-effects modelsWomenMonthsHigh levelsMenInfarctionStress ScalePerceived stress
2016
Publication and reporting of clinical trial results: cross sectional analysis across academic medical centers
Chen R, Desai NR, Ross JS, Zhang W, Chau KH, Wayda B, Murugiah K, Lu DY, Mittal A, Krumholz HM. Publication and reporting of clinical trial results: cross sectional analysis across academic medical centers. The BMJ 2016, 352: i637. PMID: 26888209, PMCID: PMC4768882, DOI: 10.1136/bmj.i637.Peer-Reviewed Original ResearchConceptsAcademic medical centerInterventional clinical trialsClinical trialsMedical CenterStudy completionPrimary completion dateClinical trial resultsReporting of resultsSectional analysisInterventional trialsProportion of trialsTrial resultsTrialsMonthsPhase IIManual reviewLead investigatorUnited StatesProportionRate of publicationReportingCompletionPatientsCenter
2015
Characteristics of Clinical Studies Conducted Over the Total Product Life Cycle of High-Risk Therapeutic Medical Devices Receiving FDA Premarket Approval in 2010 and 2011
Rathi VK, Krumholz HM, Masoudi FA, Ross JS. Characteristics of Clinical Studies Conducted Over the Total Product Life Cycle of High-Risk Therapeutic Medical Devices Receiving FDA Premarket Approval in 2010 and 2011. JAMA 2015, 314: 604-612. PMID: 26262798, DOI: 10.1001/jama.2015.8761.Peer-Reviewed Original ResearchConceptsPrimary effectiveness end pointEffectiveness end pointPostmarket studiesClinical studiesClinical evidencePMA pathwayPremarket studiesEnd pointAvailable FDA documentsInitial marketing approvalPremarket approval pathwayTherapeutic devicesMedian durationMedian enrollmentHigh-risk medical devicesMAIN OUTCOMEPatientsDrug AdministrationUS FoodFDA approvalMarketing approvalLonger durationFDA documentsMonthsPostmarketRacial Differences in Heart Failure Outcomes Evidence From the Tele-HF Trial (Telemonitoring to Improve Heart Failure Outcomes)
Qian F, Parzynski CS, Chaudhry SI, Hannan EL, Shaw BA, Spertus JA, Krumholz HM. Racial Differences in Heart Failure Outcomes Evidence From the Tele-HF Trial (Telemonitoring to Improve Heart Failure Outcomes). JACC Heart Failure 2015, 3: 531-538. PMID: 26160368, PMCID: PMC8635169, DOI: 10.1016/j.jchf.2015.03.005.Peer-Reviewed Original ResearchConceptsPatient-reported health statusKansas City Cardiomyopathy QuestionnaireHeart failureBlack patientsHealth statusHF hospitalizationRacial differencesBaseline KCCQ scoresClinical laboratory valuesPatient-reported outcomesSignificant racial differencesKCCQ scoresHF admissionsPatient demographicsWhite patientsLaboratory valuesPropensity score methodsPatientsHospitalizationOutcome evidenceMonthsLinear mixed modelsBaselineTrialsStatus
2014
Hospital Strategy Uptake and Reductions in Unplanned Readmission Rates for Patients with Heart Failure: A Prospective Study
Bradley EH, Sipsma H, Horwitz LI, Ndumele CD, Brewster AL, Curry LA, Krumholz HM. Hospital Strategy Uptake and Reductions in Unplanned Readmission Rates for Patients with Heart Failure: A Prospective Study. Journal Of General Internal Medicine 2014, 30: 605-611. PMID: 25523470, PMCID: PMC4395590, DOI: 10.1007/s11606-014-3105-5.Peer-Reviewed Original ResearchConceptsRisk-standardized readmission ratesUnplanned readmission rateUptake of strategiesReadmission ratesHeart failureProspective studyGreater reductionAvoidable Rehospitalizations (STAAR) initiativeSame time pointsFinal analytic sampleParticipantsThe studyMain MeasuresWeHospitalPatientsWeb-based surveyAnalytic sampleTime pointsBaselineHospital strategiesSignificant reductionOne-quarterMonthsMore strategiesNational sampleAssociationDescriptions and Interpretations of the ACCORD-Lipid Trial in the News and Biomedical Literature: A Cross-Sectional Analysis
Downing NS, Cheng T, Krumholz HM, Shah ND, Ross JS. Descriptions and Interpretations of the ACCORD-Lipid Trial in the News and Biomedical Literature: A Cross-Sectional Analysis. JAMA Internal Medicine 2014, 174: 1176-1182. PMID: 24796406, PMCID: PMC4124903, DOI: 10.1001/jamainternmed.2014.1371.Peer-Reviewed Original ResearchConceptsACCORD lipid trialACCORD-LipidFibrate useTrial interpretationImproved cardiovascular outcomesCross-sectional studyCross-sectional analysisStatin therapyCardiovascular outcomesCardiovascular riskDiabetes (ACCORD) trialDiabetes mellitusConflicts of interestTrialsPatientsFenofibrateAuthor conflictsLipid componentsMellitusTherapyPhysiciansMonthsUsual Source of Care and Outcomes Following Acute Myocardial Infarction
Spatz ES, Sheth SD, Gosch KL, Desai MM, Spertus JA, Krumholz HM, Ross JS. Usual Source of Care and Outcomes Following Acute Myocardial Infarction. Journal Of General Internal Medicine 2014, 29: 862-869. PMID: 24553957, PMCID: PMC4026492, DOI: 10.1007/s11606-014-2794-0.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionUsual sourceMyocardial infarctionMortality rateBaseline risk factorsAcute clinical eventsMain outcome measuresAMI severityAMI patientsMultivariable analysisKey ResultsAmongClinical eventsSocio-demographic characteristicsRisk factorsOutcome measuresReadmissionHigh mortalityPatientsMortalityCareMonthsInfarctionAdultsOutcomesAssociation
2012
Publication of NIH funded trials registered in ClinicalTrials.gov: cross sectional analysis
Ross JS, Tse T, Zarin DA, Xu H, Zhou L, Krumholz HM. Publication of NIH funded trials registered in ClinicalTrials.gov: cross sectional analysis. The BMJ 2012, 344: d7292. PMID: 22214755, PMCID: PMC3623605, DOI: 10.1136/bmj.d7292.Peer-Reviewed Original Research
2011
Use of Fibrates in the United States and Canada
Jackevicius CA, Tu JV, Ross JS, Ko DT, Carreon D, Krumholz HM. Use of Fibrates in the United States and Canada. JAMA 2011, 305: 1217-1224. PMID: 21427374, PMCID: PMC3332101, DOI: 10.1001/jama.2011.353.Peer-Reviewed Original ResearchMeSH KeywordsCanadaCardiovascular DiseasesCohort StudiesCosts and Cost AnalysisDiabetes Mellitus, Type 2Drug CostsDrugs, GenericFenofibrateFibric AcidsHealth ExpendituresHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic AgentsMedical AuditPractice Patterns, Physicians'PrescriptionsUnited StatesConceptsUse of fibratesRole of fibratesObservational cohort studyIMS Health dataFenofibrate useCardiovascular riskCohort studyDiabetes (ACCORD) trialClinical benefitFibratesMonthsPrescriptionUnited StatesPatientsNegative resultsFenofibrateHealth dataCurrent useGeneric formulationPopulationStatinsTherapyTrials
2008
The Relationship Between Anemia, Change in Hematocrit Over Time and Change in Health Status in Patients With Heart Failure After Myocardial Infarction
Kosiborod M, Krumholz HM, Jones PG, Pitt B, Spertus JA. The Relationship Between Anemia, Change in Hematocrit Over Time and Change in Health Status in Patients With Heart Failure After Myocardial Infarction. Journal Of Cardiac Failure 2008, 14: 27-34. PMID: 18226770, DOI: 10.1016/j.cardfail.2007.09.009.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnemiaCohort StudiesFemaleHealth Status IndicatorsHeart FailureHeart Function TestsHematocritHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionProbabilityPrognosisQuality of LifeRisk AssessmentSickness Impact ProfileSurveys and QuestionnairesSurvival AnalysisTime FactorsConceptsKansas City Cardiomyopathy QuestionnaireHeart failureHealth status gainsHealth statusBaseline hematocritInitial hematocritMyocardial infarctionPatient’s initial hematocritPotential therapeutic targetHealth status assessmentMultivariable adjustmentAnemic patientsSevere anemiaSerial hematocritsHematocrit levelsPatientsTherapeutic targetHematocrit changesHematocritAnemiaInfarctionLinear regression modelsMonthsRegression modelsSignificant changes
2007
Association Between Angina and Treatment Satisfaction after Myocardial Infarction
Plomondon ME, Magid DJ, Masoudi FA, Jones PG, Barry LC, Havranek E, Peterson ED, Krumholz HM, Spertus JA, Rumsfeld JS, for the PREMIER Investigators. Association Between Angina and Treatment Satisfaction after Myocardial Infarction. Journal Of General Internal Medicine 2007, 23: 1-6. PMID: 17955303, PMCID: PMC2173926, DOI: 10.1007/s11606-007-0430-y.Peer-Reviewed Original ResearchConceptsLower treatment satisfactionSeattle Angina QuestionnaireTreatment satisfactionMyocardial infarctionPresence of anginaResultsSixty-two percentQuality of carePersistent anginaAngina QuestionnaireClinical factorsMultivariable analysisMI patientsNew anginaUnadjusted analysesBackgroundPatient satisfactionAnginaMultivariable regressionTransient anginaU.S. CentersConclusionsIn conclusionPatientsMonthsInfarctionPossible targetsCarePredictors of weight change in overweight patients with myocardial infarction
Fadl YY, Krumholz HM, Kosiborod M, Masoudi FA, Peterson PN, Reid KJ, Weintraub WS, Buchanan DM, Spertus JA. Predictors of weight change in overweight patients with myocardial infarction. American Heart Journal 2007, 154: 711-717. PMID: 17892997, DOI: 10.1016/j.ahj.2007.06.006.Peer-Reviewed Original ResearchConceptsPost-MI patientsMyocardial infarctionOverweight patientsWeight changeWeight lossDepression 1 monthMean weight changePercent weight changeMultivariable linear regressionBaseline obesityOverweight survivorsMorbid obesityObese patientsProspective cohortMultivariable analysisIndependent correlatesWeight managementLifestyle characteristicsPatientsMean increasePREMIER studyHealth insuranceMonthsOverweightInfarction
2006
Impact of Medication Therapy Discontinuation on Mortality After Myocardial Infarction
Ho PM, Spertus JA, Masoudi FA, Reid KJ, Peterson ED, Magid DJ, Krumholz HM, Rumsfeld JS. Impact of Medication Therapy Discontinuation on Mortality After Myocardial Infarction. JAMA Internal Medicine 2006, 166: 1842-1847. PMID: 17000940, DOI: 10.1001/archinte.166.17.1842.Peer-Reviewed Original ResearchConceptsTherapy discontinuationMyocardial infarctionEvidence-based medicationsMulticenter prospective cohortUse of aspirinMultivariable survival analysisTransitions of careDiscontinuation of useProspective registryMortality benefitProspective cohortMultivariable analysisOutpatient settingMI hospitalizationDiscontinuationMortality riskMedicationsPatientsSurvival analysisHigh mortalityMortalityTreatment factorsMonthsInfarctionAspirinPerceived control and change in physical functioning after coronary artery bypass grafting: A prospective study
Barry LC, Kasl SV, Lichtman J, Vaccarino V, Krumholz HM. Perceived control and change in physical functioning after coronary artery bypass grafting: A prospective study. International Journal Of Behavioral Medicine 2006, 13: 229-236. PMID: 17078773, DOI: 10.1207/s15327558ijbm1303_6.Peer-Reviewed Original ResearchConceptsHealth-related controlCoronary artery bypassPhysical functioningArtery bypassHospital dischargeIndependent predictorsProspective studyCaucasian manMean ageSignificant associationOne-way analysisMeasure outcomesBypassIntervention effortsMonthsWeeksX timeSignificant interactionBeneficial impactPositive changesPatientsPrevalence, Predictors, and Outcomes of Premature Discontinuation of Thienopyridine Therapy After Drug-Eluting Stent Placement
Spertus JA, Kettelkamp R, Vance C, Decker C, Jones PG, Rumsfeld JS, Messenger JC, Khanal S, Peterson ED, Bach RG, Krumholz HM, Cohen DJ. Prevalence, Predictors, and Outcomes of Premature Discontinuation of Thienopyridine Therapy After Drug-Eluting Stent Placement. Circulation 2006, 113: 2803-2809. PMID: 16769908, DOI: 10.1161/circulationaha.106.618066.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, Balloon, CoronaryCardiovascular AgentsCause of DeathClopidogrelCombined Modality TherapyCoronary RestenosisDrug Administration ScheduleDrug ImplantsFemaleFollow-Up StudiesHospitalizationHumansLife TablesMaleMiddle AgedMortalityMyocardial InfarctionPatient Education as TopicPlatelet Aggregation InhibitorsPrevalenceProportional Hazards ModelsProspective StudiesPyridinesRegistriesSirolimusStentsSurvival AnalysisThrombosisTiclopidineTreatment OutcomeTreatment RefusalConceptsDrug-eluting stentsThienopyridine therapyMI patientsMyocardial infarctionCardiac rehabilitation referralUse of thienopyridinesAcute myocardial infarctionPremature discontinuationDES placementRehabilitation referralHospitalization ratesStent thrombosisDischarge instructionsStent placementCardiovascular diseaseSubsequent mortalityPatientsDES treatmentTherapyHealth careMonthsThienopyridinesMortalityPrevalenceDays