Guy I. Sydney, MD
Clinical Fellow T32Cards
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Research
Publications
2026
Immune therapies in type 1 diabetes deserve immune biomarkers.
Sydney GI, Paschou SA. Immune therapies in type 1 diabetes deserve immune biomarkers. Diabetes Res Clin Pract 2026, 113435. PMID: 42442554, DOI: 10.1016/j.diabres.2026.113435.Peer-Reviewed Original Research
2025
Towards insulin independence in type 1 diabetes: Prospects for prevention and cure
Sydney G, Perdigoto A, Herold K. Towards insulin independence in type 1 diabetes: Prospects for prevention and cure. PLOS Medicine 2025, 22: e1004813. PMID: 41289263, PMCID: PMC12646415, DOI: 10.1371/journal.pmed.1004813.Peer-Reviewed Original ResearchMON-624 Insulin Therapy in Steroid-Induced Ketoacidosis (SIKA) with Normoglycemia
Sydney G. MON-624 Insulin Therapy in Steroid-Induced Ketoacidosis (SIKA) with Normoglycemia. Journal Of The Endocrine Society 2025, 9: bvaf149.985. PMCID: PMC12543755, DOI: 10.1210/jendso/bvaf149.985.Peer-Reviewed Original ResearchImmune effector cell-associated neurotoxicity syndromeLipolytic effects of growth hormoneEffects of growth hormoneB-cell lymphomaMetabolic acidosisGrowth hormoneLipolytic effectDiabetic ketoacidosisTreated with high-dose dexamethasoneNon-Hodgkin's B-cell lymphomaComplex pathophysiologyHigh indexHigh index of suspicionHigh-dose dexamethasoneSevere metabolic derangementAbsence of overt hyperglycemiaIndex of suspicionAdipose triglyceride lipaseAssociated with insulin deficiencyHormone-sensitive lipaseCounter-regulatory hormonesElevated beta-hydroxybutyratePatient's acidosisDextrose infusionAcute nauseaSUN-770 Severe Hypocalcemia in Diffuse Metastatic Prostate Cancer: Impact of Osteoblastic Lesions and Denosumab Therapy
Sydney G, Balasubramanian P. SUN-770 Severe Hypocalcemia in Diffuse Metastatic Prostate Cancer: Impact of Osteoblastic Lesions and Denosumab Therapy. Journal Of The Endocrine Society 2025, 9: bvaf149.718. PMCID: PMC12545657, DOI: 10.1210/jendso/bvaf149.718.Peer-Reviewed Original ResearchMetastatic prostate cancerOsteoblastic bone lesionsRisk of hypocalcemiaProstate cancerOsteoblastic metastasesDenosumab therapyAntiresorptive agentsBone lesionsVitamin DIncidence of skeletal related eventsCalcium levelsMultifaceted etiologyExtensive skeletal metastasesSymptoms of hypocalcemiaPoor oral intakeAdvanced prostate cancerSkeletal related eventsSerum calcium levelsLife-threatening complicationsBilateral subdural hematomasEtiology of hypocalcemiaDoses of calciumMagnesium repletionBone painDenosumab dosesMON-117 GnRH Agonist Therapy Induced Pituitary Apoplexy
Sydney G, balasubramanian P. MON-117 GnRH Agonist Therapy Induced Pituitary Apoplexy. Journal Of The Endocrine Society 2025, 9: bvaf149.1445. PMCID: PMC12544274, DOI: 10.1210/jendso/bvaf149.1445.Peer-Reviewed Original ResearchGnRH agonist therapyIn vitro fertilizationPituitary apoplexyAgonist therapyPituitary adenomasPatient's clinical stabilityOptic chiasmSurgical interventionNeurological deficitsAdenoma growthPituitary glandRisk of pituitary apoplexyDiagnosis of pituitary adenomaNonfunctioning pituitary adenomasMass effectHistory of infertilityCranial nerve examLack of neurological deficitsGonadotropin-releasing hormoneMRI pituitaryPituitary massElevated prolactinIntractable headacheRecurrent miscarriageStalk effectSAT-615 Acute Liver Injury Impairing Ketogenesis and Insulin Clearance in a Type 1 Diabetic with Recurrent Hypoglycemia
Sydney G. SAT-615 Acute Liver Injury Impairing Ketogenesis and Insulin Clearance in a Type 1 Diabetic with Recurrent Hypoglycemia. Journal Of The Endocrine Society 2025, 9: bvaf149.1141. PMCID: PMC12544677, DOI: 10.1210/jendso/bvaf149.1141.Peer-Reviewed Original ResearchChronic kidney diseaseImpaired ketogenesisLiver dysfunctionRecurrent episodesDiabetic ketoacidosisHistory of type 1 diabetes mellitusUnique presentationInsulin clearanceHepatic functionRecurrent episodes of severe hypoglycemiaHistory of diabetic ketoacidosisGlucose homeostasisMonths prior to presentationEpisodes of severe hypoglycemiaReduced ejection fractionAcute liver dysfunctionType 1 diabetes mellitusLife-threatening complicationsImpaired hepatic functionSignificant metabolic disturbancesCombination of malnutritionAbsence of ketosisAcute liver injurySeverity of hypoglycemiaMRSA bacteremiaMoving the Goalposts Closer: Using Intermediate End Points in Type 1 Diabetes Prevention Trials.
Sydney G, Wu S, Herold K. Moving the Goalposts Closer: Using Intermediate End Points in Type 1 Diabetes Prevention Trials. Diabetes Care 2025, 48: 1318-1319. PMID: 40690655, PMCID: PMC12279035, DOI: 10.2337/dci25-0041.Commentaries, Editorials and LettersCystic Fibrosis and Hemochromatosis Carriers May Be Prone to Glucagon-like Peptide-1 Agonist Pancreatitis: 3 Cases
Sydney G, Do T, West W, Uwaifo G. Cystic Fibrosis and Hemochromatosis Carriers May Be Prone to Glucagon-like Peptide-1 Agonist Pancreatitis: 3 Cases. JCEM Case Reports 2025, 3: luaf104. PMID: 40384889, PMCID: PMC12078934, DOI: 10.1210/jcemcr/luaf104.Peer-Reviewed Original ResearchGlucagon-like peptide-1Cystic fibrosisPathogenic variantsHeterozygous carriersAcute pancreatitisCarrier stateAssociated with potential adverse effectsType 2 diabetesManagement of type 2 diabetesPotential adverse effectsGenetic testingTrue risk factorRisk factorsPeptide-1Case 2FibrosisHemochromatosisCase 3Adverse effectsPancreatitisPatientsHC geneTherapeutic scopeAgonistsBeyond Glucose Levels: Redefining Diabetic Ketoacidosis—A Case of Hypoglycemic Diabetic Ketoacidosis
Sydney G. Beyond Glucose Levels: Redefining Diabetic Ketoacidosis—A Case of Hypoglycemic Diabetic Ketoacidosis. AACE Endocrinology And Diabetes 2025, 11: 148-150. PMID: 40201456, PMCID: PMC11973659, DOI: 10.1016/j.aace.2025.01.001.Peer-Reviewed Original ResearchSodium-glucose cotransporter 2 inhibitorsDiabetic ketoacidosisAtypical presentationGlucose levelsManifestations of diabetic ketoacidosisPresentation of diabetic ketoacidosisEuglycemic diabetic ketoacidosisAcute gallstone pancreatitisType 2 diabetes mellitusLevel of suspicionHistory of hypertensionPresence of hyperglycemiaLife-threatening conditionSerum glucose levelsConcomitant hypoglycemiaBeta-hydroxybutyrate levelsGallstone pancreatitisDelayed DiagnosisSodium-glucoseMetabolic acidosisBicarbonate levelsKetoacidosisDKA protocolAnion gapLaboratory evaluation
2024
Impact of a tracheal aspirate culture diagnostic test stewardship intervention in a tertiary care PICU
Chiotos K, Lee G, Sydney G, Woods-Hill C, Wolfe H, Stinson H, Piccione J, Blumenthal J, Keim G, Li Y, Traynor D, Dudhia A, Doll A, Harris R, Gerber J. Impact of a tracheal aspirate culture diagnostic test stewardship intervention in a tertiary care PICU. Infection Control And Hospital Epidemiology 2024, 45: 943-951. PMID: 39229740, DOI: 10.1017/ice.2024.105.Peer-Reviewed Original ResearchConceptsTracheal aspirate culturesVentilator-associated infectionDays of therapyVentilator daysAspirate culturesCulture rateStewardship interventionsAntibiotic days of therapyMechanically ventilated childrenSecondary analysisLength of stayTertiary care PICUAntibiotic coursesConsensus guidelinesTertiary PICUPreintervention baselineDays postinterventionTrachealPlan-Do-Study-Act cyclesGuideline implementationPoisson regressionVentilationPostintervention periodPICUInfection
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