2015
The statistical geometry of transcriptome divergence in cell-type evolution and cancer
Liang C, Forrest A, Wagner G. The statistical geometry of transcriptome divergence in cell-type evolution and cancer. Nature Communications 2015, 6: 6066. PMID: 25585899, DOI: 10.1038/ncomms7066.Peer-Reviewed Original ResearchConceptsCell typesCell type modelCell type evolutionAncestral cell typeSister cell typesNovel cell typesGene expression profilesTranscriptome divergenceOrganismal complexityTranscriptomic dataExpression profilesCancer cell linesTranscriptomeCancer cellsCell linesNormal cellsKey predictionsStatistical geometryFANTOM5Statistical modelCellsEncodesTree structureLittle understandingDivergence
1996
Apparent Stabilizing Selection and the Maintenance of Neutral Genetic Variation
Wagner G. Apparent Stabilizing Selection and the Maintenance of Neutral Genetic Variation. Genetics 1996, 143: 617-619. PMID: 8722811, PMCID: PMC1207295, DOI: 10.1093/genetics/143.1.617.Peer-Reviewed Original Research