2015
Homology in the Age of Developmental Genomics
Wagner G. Homology in the Age of Developmental Genomics. 2015, 25-43. DOI: 10.1007/978-3-7091-1862-7_2.Peer-Reviewed Original ResearchModel organismsEvolutionary biologyHomology conceptRecent common ancestorDevelopmental genomicsPhylogenetic relationshipsCommon ancestorDarwinian traditionHomologySame organOrganismsSpeciesComparative anatomyDifferent animalsBiologistsBiologyFundamental roleRichard OwenImportant roleGenomicsAncestorGenesOrgansHumansRole
2014
Evolutionary Systems Biology: Shifting Focus to the Context‐Dependency of Genetic Effects
Pavličev M, Wagner G. Evolutionary Systems Biology: Shifting Focus to the Context‐Dependency of Genetic Effects. 2014, 91-108. DOI: 10.1002/9781118398814.ch6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsReinventing the Organism: Evolvability and Homology in Post-Dahlem Evolutionary Biology
Wagner G. Reinventing the Organism: Evolvability and Homology in Post-Dahlem Evolutionary Biology. Boston Studies In The Philosophy And History Of Science 2014, 307: 327-342. DOI: 10.1007/978-94-017-9412-1_15.Peer-Reviewed Original ResearchEvolutionary biologyDahlem ConferenceGenotype-phenotype mapStructure of organismsLimited pleiotropyNatural selectionEvolutionary causationPhenotype evolutionOrganism conceptRandom mutationsHomologyOrganismsEvolvabilityBiologyDevelopmental structuresMutationsDevelopmental organizationPleiotropySeedsFitnessSelectionAdaptation
2012
Coming to Grips with Evolvability
Pavlicev M, Wagner G. Coming to Grips with Evolvability. Evolution: Education And Outreach 2012, 5: 231-244. DOI: 10.1007/s12052-012-0430-1.Peer-Reviewed Original ResearchGenotype-phenotype mapOrganismal developmentMost genesCryptic mutationsPhenotypic traitsComplex organismsPhenotypic charactersMost traitsRandom mutationsReal organismsGenetic effectsEvolvabilityGenetic backgroundOrganismsGenesMutationsTraitsNew environmentRandom changesPhenotypeFitnessEvolutionSelectionConventional computer languages
2008
Pleiotropic scaling of gene effects and the ‘cost of complexity’
Wagner GP, Kenney-Hunt JP, Pavlicev M, Peck JR, Waxman D, Cheverud JM. Pleiotropic scaling of gene effects and the ‘cost of complexity’. Nature 2008, 452: 470-472. PMID: 18368117, DOI: 10.1038/nature06756.Peer-Reviewed Original ResearchConceptsQuantitative trait lociEffects of pleiotropyOrganismal complexityGenetic sequence dataHigher organismsEvolutionary biologyTrait lociMouse genomeSequence dataBiology questionsSkeletal traitsGene effectsMost mutationsCost of complexityGenetic mutationsTraitsMutationsMultiple effectsGenomeSkeletal characteristicsPleiotropyLociPleiotropicOrganismsBiology
2001
Function and the Evolution of Phenotypic Stability: Connecting Pattern to Process1
Schwenk K, Wagner G. Function and the Evolution of Phenotypic Stability: Connecting Pattern to Process1. Integrative And Comparative Biology 2001, 41: 552-563. DOI: 10.1093/icb/41.3.552.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPhenotypic stabilityPhylogenetic character analysisCurrent environmental conditionsSelection differsEnvironmental selectionEnvironmental conditionsInternal selectionExternal selectionSystem-level functionalityCharacter analysisCertain charactersOrganismsSelectionPhenotypeCascadeFunctional integrationCharacterFunctionPatternsResponseWide range
2000
Character identification in evolutionary biology: The role of the organism
Wagner G, Laubichler M. Character identification in evolutionary biology: The role of the organism. Theory In Biosciences 2000, 119: 20-40. DOI: 10.1007/s12064-000-0003-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsBiological processesBiological charactersImportant biological charactersHigher-level biological processesAdaptive evolutionEvolutionary biologyMathematical theoryRelevant charactersMathematical modelCharacter decompositionOrganismsBiologyOrganismic perspectiveBiological modelsPhysical sciencesBiological theoryIdentificationTheoryTraitsInheritanceModelAnalytical methodCellsCharacterAppropriate instances
1999
Is Hsp90 a regulator of evolvability?
Wagner G, Chiu C, Hansen T. Is Hsp90 a regulator of evolvability? Journal Of Experimental Zoology 1999, 285: 116-118. PMID: 10440722, DOI: 10.1002/(sici)1097-010x(19990815)285:2<116::aid-jez3>3.0.co;2-p.Commentaries, Editorials and LettersA Research Programme for Testing the Biological Homology Concept
Wagner G. A Research Programme for Testing the Biological Homology Concept. Novartis Foundation Symposia 1999, 222: 125-140. PMID: 10332757, DOI: 10.1002/9780470515655.ch9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBiological homology conceptPutative homologuesHomology conceptMode of developmentDistribution of homologuesPhylogenetic distributionDevelopmental processesHomologuesMechanistic contextVariation patternsEnormous wealthAnatomical patternsCladeVariational tendencyOrganismsVariational differencesPatternsVariational propertiesDevelopmentWide range