2024
Faecal proteomics links neutrophil degranulation with mortality in patients with alcohol-associated hepatitis
Kreimeyer H, Gonzalez C, Fondevila M, Hsu C, Hartmann P, Zhang X, Stärkel P, Bosques-Padilla F, Verna E, Abraldes J, Brown R, Vargas V, Altamirano J, Caballería J, Shawcross D, Louvet A, Lucey M, Mathurin P, Garcia-Tsao G, Bataller R, Investigators A, Gonzalez D, Schnabl B. Faecal proteomics links neutrophil degranulation with mortality in patients with alcohol-associated hepatitis. Gut 2024, gutjnl-2024-332730. PMID: 39033024, DOI: 10.1136/gutjnl-2024-332730.Peer-Reviewed Original ResearchAlcohol-associated hepatitisShort-term survivalMulticentre cohortSeverity of ALDAlcohol-associated liver diseaseIndependent validation cohortInduce gut dysbiosisNon-invasive markerAlcohol-use disordersNeutrophil degranulationPrediction of short-term survivalPrognostic effectHepatic neutrophilsValidation cohortBacterial translocationNeutrophil granulesMPO levelsLiver diseaseFecal biomarkersTandem mass tagPatientsGut dysbiosisLiver damageDisease severityNeutrophils
1981
Relationship between blood lactic acid and serum proline in alcoholic liver cirrhosis
Kershenobich D, García-Tsao G, Saldana S, Rojkind M. Relationship between blood lactic acid and serum proline in alcoholic liver cirrhosis. Gastroenterology 1981, 80: 1012-1015. PMID: 7202961, DOI: 10.1016/0016-5085(81)90074-3.Peer-Reviewed Original ResearchConceptsBlood lactic acidAlcoholic cirrhotic patientsAlcoholic liver diseaseAlcoholic cirrhoticsCirrhotic patientsLiver diseaseSerum prolineBlood lactateAlcoholic liver cirrhosisChronic liver diseaseNonalcoholic cirrhotic patientsNon-alcoholic volunteersMean control valueLiver cirrhosisAlcohol intakeAlcoholic patientsLiver damageLiver fibrogenesisAcute intoxicationCirrhoticsPatientsNormal valuesPossible markerControl valuesInhibitory effect